Gene Page: FCHO1
Summary ?
| GeneID | 23149 |
| Symbol | FCHO1 |
| Synonyms | - |
| Description | FCH domain only 1 |
| Reference | MIM:613437|HGNC:HGNC:29002|Ensembl:ENSG00000130475|HPRD:16887|Vega:OTTHUMG00000183293 |
| Gene type | protein-coding |
| Map location | 19p13.11 |
| Pascal p-value | 0.02 |
| Sherlock p-value | 0.805 |
| eGene | Cerebellum Myers' cis & trans |
| Support | CompositeSet Darnell FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs201062 | chr10 | 10985931 | FCHO1 | 23149 | 0.13 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CHD8 | 0.98 | 0.98 |
| SUV420H1 | 0.97 | 0.97 |
| KDM4A | 0.97 | 0.98 |
| ZNF518B | 0.96 | 0.97 |
| TCEB3 | 0.96 | 0.96 |
| C6orf174 | 0.96 | 0.97 |
| ASXL1 | 0.96 | 0.97 |
| MED1 | 0.96 | 0.97 |
| ZNF623 | 0.96 | 0.97 |
| RSPRY1 | 0.96 | 0.97 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AIFM3 | -0.75 | -0.80 |
| HLA-F | -0.75 | -0.79 |
| AF347015.31 | -0.75 | -0.91 |
| MT-CO2 | -0.74 | -0.92 |
| FXYD1 | -0.74 | -0.91 |
| TSC22D4 | -0.74 | -0.82 |
| AF347015.27 | -0.74 | -0.89 |
| S100B | -0.74 | -0.85 |
| C5orf53 | -0.74 | -0.76 |
| AF347015.33 | -0.73 | -0.87 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
| KOYAMA SEMA3B TARGETS DN | 411 | 249 | All SZGR 2.0 genes in this pathway |
| PASQUALUCCI LYMPHOMA BY GC STAGE DN | 165 | 104 | All SZGR 2.0 genes in this pathway |
| PENG LEUCINE DEPRIVATION DN | 187 | 122 | All SZGR 2.0 genes in this pathway |
| HU GENOTOXIN ACTION DIRECT VS INDIRECT 24HR | 55 | 38 | All SZGR 2.0 genes in this pathway |
| DASU IL6 SIGNALING SCAR UP | 30 | 21 | All SZGR 2.0 genes in this pathway |
| LEE METASTASIS AND ALTERNATIVE SPLICING DN | 45 | 31 | All SZGR 2.0 genes in this pathway |
| BONOME OVARIAN CANCER POOR SURVIVAL DN | 22 | 15 | All SZGR 2.0 genes in this pathway |
| BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING | 510 | 309 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | 456 | 285 | All SZGR 2.0 genes in this pathway |
| TAVAZOIE METASTASIS | 108 | 68 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME2 | 491 | 319 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| DASU IL6 SIGNALING UP | 59 | 44 | All SZGR 2.0 genes in this pathway |
| BHAT ESR1 TARGETS VIA AKT1 UP | 281 | 183 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP D | 280 | 158 | All SZGR 2.0 genes in this pathway |