Gene Page: CLASP1

Summary
GeneID  23332
Symbol  CLASP1
Synonyms  DKFZp686D1968|DKFZp686H2039|FLJ33821|FLJ41222|KIAA0622|MAST1|MGC131895
Description  cytoplasmic linker associated protein 1
See related  HGNC:17088|MIM:605852|Ensembl:ENSG00000074054|HPRD:09322|
Locus tag  -
Gene type  protein-coding
Map location  2q14.2-q14.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.023 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00755 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SNX170.870.90
C20orf290.870.86
RPUSD30.860.84
ACTR1B0.860.85
RHBDD20.850.88
UBL70.850.86
ABHD14A0.850.84
TRUB20.840.87
P4HTM0.840.84
C20orf300.840.87
Top 10 negatively co-expressed genes
EIF5B-0.57-0.64
AC010300.1-0.49-0.57
AC005921.3-0.48-0.66
AF347015.18-0.47-0.32
NSBP1-0.45-0.42
ANP32C-0.43-0.45
ZNF326-0.39-0.35
AC100783.1-0.39-0.31
HSP90AB4P-0.38-0.42
SFRS18-0.38-0.52
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI15631994 |17342765 
GO:0051010microtubule plus-end bindingIDA12837247 
GO:0043515kinetochore bindingIMP12837247 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001578microtubule bundle formationIMP12837247 
GO:0007026negative regulation of microtubule depolymerizationIGI15631994 
GO:0007026negative regulation of microtubule depolymerizationIMP16866869 
GO:0007163establishment or maintenance of cell polarityNAS15928712 
GO:0007049cell cycleIEA-
GO:0007067mitosisIEA-
GO:0010458exit from mitosisIMP16866869 
GO:0051301cell divisionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000777condensed chromosome kinetochoreIEA-
GO:0005794Golgi apparatusIDA15631994 
GO:0005828kinetochore microtubuleTAS12837247 
GO:0005856cytoskeletonIEA-
GO:0005881cytoplasmic microtubuleIDA11290329 
GO:0005737cytoplasmIEA-
GO:0030981cortical microtubule cytoskeletonIDA12837247 
GO:0031592centrosomal coronaIDA16914514 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CLIP2CLIP | CLIP-115 | CYLN2 | KIAA0291 | MGC11333 | WBSCR3 | WBSCR4 | WSCR3 | WSCR4CAP-GLY domain containing linker protein 2Reconstituted ComplexBioGRID11290329 
MAPRE1EB1 | MGC117374 | MGC129946microtubule-associated protein, RP/EB family, member 1CLASP1-alpha interacts with EB1. This interaction was modelled on a demonstrated interaction between human CLASP1-alpha and EB1 from mouse and monkey.BIND15631994 
MAPRE3EB3 | EBF3 | EBF3-S | RP3microtubule-associated protein, RP/EB family, member 3CLASP1-alpha interacts with EB3.BIND15631994 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideAffinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 6643All SZGR genes in this pathway
REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 5938All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ROBO_RECEPTOR 3026All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_MITOTIC_G2_G2_M_PHASES 8150All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_MITOTIC_PROMETAPHASE 8751All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
LUI_THYROID_CANCER_PAX8_PPARG_UP 4429All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_1 5133All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
ULE_SPLICING_VIA_NOVA2 4338All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G6 153112All SZGR genes in this pathway
OUILLETTE_CLL_13Q14_DELETION_UP 7440All SZGR genes in this pathway
CHENG_IMPRINTED_BY_ESTRADIOL 11068All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION 13087All SZGR genes in this pathway
WINNEPENNINCKX_MELANOMA_METASTASIS_UP 16286All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
LINSLEY_MIR16_TARGETS 206127All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1352292351Ahsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-1811611681A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-194291829241Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-200bc/429115121m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-2142562631A,m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-2191101161Ahsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-320133139m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-32329993005m8hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-370184418501Ahsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
miR-493-5p29782984m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-494295029561Ahsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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