Gene Page: ALPP
Summary ?
| GeneID | 250 |
| Symbol | ALPP |
| Synonyms | ALP|PALP|PLAP|PLAP-1 |
| Description | alkaline phosphatase, placental |
| Reference | MIM:171800|HGNC:HGNC:439|Ensembl:ENSG00000163283|Vega:OTTHUMG00000133255 |
| Gene type | protein-coding |
| Map location | 2q37 |
| Pascal p-value | 0.006 |
| Sherlock p-value | 0.743 |
| eGene | Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs13398149 | chr2 | 232564880 | ALPP | 250 | 0.19 | cis | ||
| rs17025692 | chr1 | 110911272 | ALPP | 250 | 0.19 | trans | ||
| snp_a-2169623 | 0 | ALPP | 250 | 0.09 | trans | |||
| rs11754465 | chr6 | 11761260 | ALPP | 250 | 0.05 | trans | ||
| rs1587434 | chr6 | 66615354 | ALPP | 250 | 0.11 | trans | ||
| rs10503771 | chr8 | 25304019 | ALPP | 250 | 0.2 | trans | ||
| rs16924671 | chr9 | 8309533 | ALPP | 250 | 0.11 | trans | ||
| rs5998188 | chr22 | 32344841 | ALPP | 250 | 0.02 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG FOLATE BIOSYNTHESIS | 11 | 10 | All SZGR 2.0 genes in this pathway |
| ZHONG RESPONSE TO AZACITIDINE AND TSA UP | 183 | 119 | All SZGR 2.0 genes in this pathway |
| GOZGIT ESR1 TARGETS UP | 149 | 84 | All SZGR 2.0 genes in this pathway |
| FURUKAWA DUSP6 TARGETS PCI35 UP | 74 | 32 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
| FERRANDO T ALL WITH MLL ENL FUSION UP | 87 | 67 | All SZGR 2.0 genes in this pathway |
| HELLER HDAC TARGETS SILENCED BY METHYLATION UP | 461 | 298 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS DN | 414 | 237 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |