Gene Page: GABRG2

Summary ?
GeneID2566
SymbolGABRG2
SynonymsCAE2|ECA2|GEFSP3
Descriptiongamma-aminobutyric acid type A receptor gamma2 subunit
ReferenceMIM:137164|HGNC:HGNC:4087|Ensembl:ENSG00000113327|HPRD:00663|Vega:OTTHUMG00000130350
Gene typeprotein-coding
Map location5q34
Pascal p-value1.897E-4
Sherlock p-value0.85
Fetal beta-2.455
SupportLIGAND GATED ION SIGNALING

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_IGenome scan meta-analysisPsr: 0.0032 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00459 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AP4M10.920.92
SIRT60.910.91
ACTL6B0.900.91
KAT50.900.91
ZMYND190.900.88
MED220.900.90
STK190.900.89
ACD0.900.91
MIIP0.900.89
TRMT10.890.91
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.75-0.79
AF347015.27-0.75-0.80
MT-CO2-0.75-0.78
MT-CYB-0.75-0.80
AF347015.8-0.74-0.80
AF347015.33-0.73-0.77
AF347015.15-0.72-0.79
AF347015.2-0.71-0.77
AF347015.26-0.68-0.77
AF347015.21-0.67-0.80

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0030594neurotransmitter receptor activityIEANeurotransmitter (GO term level: 5)-
GO:0004890GABA-A receptor activityIEAGABA (GO term level: 7)-
GO:0008503benzodiazepine receptor activityTASGABA, Neurotransmitter (GO term level: 6)2538761 
GO:0005515protein bindingIPI9892355 
GO:0005254chloride channel activityIEA-
GO:0005216ion channel activityIEA-
GO:0005230extracellular ligand-gated ion channel activityIEA-
GO:0031404chloride ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007214gamma-aminobutyric acid signaling pathwayIEAGABA, Neurotransmitter (GO term level: 8)-
GO:0007214gamma-aminobutyric acid signaling pathwayTASGABA, Neurotransmitter (GO term level: 8)2538761 
GO:0006821chloride transportIEA-
GO:0006811ion transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS2538761 
GO:0030054cell junctionIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137110All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME GABA A RECEPTOR ACTIVATION 1212All SZGR 2.0 genes in this pathway
REACTOME GABA RECEPTOR ACTIVATION 5240All SZGR 2.0 genes in this pathway
REACTOME ION CHANNEL TRANSPORT 5542All SZGR 2.0 genes in this pathway
REACTOME LIGAND GATED ION CHANNEL TRANSPORT 2121All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357212All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC UP 6238All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA PROGNOSIS DN 4328All SZGR 2.0 genes in this pathway
NIELSEN LEIOMYOSARCOMA CNN1 UP 1913All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253192All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/107214121481A,m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-150191119181A,m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-493-5p5275341A,m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-4965375431Ahsa-miR-496AUUACAUGGCCAAUCUC
hsa-miR-496AUUACAUGGCCAAUCUC