Gene Page: TINF2

Summary
GeneID  26277
Symbol  TINF2
Synonyms  TERF2|TIN2|TIN2L
Description  TERF1 (TRF1)-interacting nuclear factor 2
See related  HGNC:11824|MIM:604319|Ensembl:ENSG00000092330|HPRD:16056|
Locus tag  -
Gene type  protein-coding
Map location  14q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.047 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingTAS10581025 
GO:0005515protein bindingIPI12768206 
GO:0042162telomeric DNA bindingIDA12768206 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007004telomere maintenance via telomeraseTAS10581025 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000781chromosome, telomeric regionTAS10581025 
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP16166375 
GO:0005694chromosomeIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACDPIP1 | PTOP | TINT1 | TPP1adrenocortical dysplasia homolog (mouse)-HPRD,BioGRID15181449 |15231715 
PTOP interacts with TIN2.BIND15181449 
POT1DKFZp586D211 | hPot1POT1 protection of telomeres 1 homolog (S. pombe)Affinity Capture-MS
Affinity Capture-Western		BioGRID12768206 |15181449 
|15231715 
TERF1FLJ41416 | PIN2 | TRBF1 | TRF | TRF1 | hTRF1-AS | t-TRF1telomeric repeat binding factor (NIMA-interacting) 1-HPRD,BioGRID10581025 
TIN2 interacts with TRF1.BIND15316005 
TERF2TRBF2 | TRF2telomeric repeat binding factor 2Affinity Capture-MSBioGRID15181449 
TIN2 interacts with TRF2.BIND15316005 
-HPRD15292264 
TERF2IPDRIP5 | RAP1telomeric repeat binding factor 2, interacting proteinAffinity Capture-MSBioGRID15181449 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
REACTOME_MEIOSIS 11681All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CHROMOSOME_MAINTENANCE 12280All SZGR genes in this pathway
REACTOME_MEIOTIC_SYNAPSIS 7357All SZGR genes in this pathway
REACTOME_PACKAGING_OF_TELOMERE_ENDS 4840All SZGR genes in this pathway
REACTOME_TELOMERE_MAINTENANCE 7557All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_UP 10869All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN 382224All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM 302191All SZGR genes in this pathway
HU_GENOTOXIN_ACTION_DIRECT_VS_INDIRECT_24HR 5538All SZGR genes in this pathway
BILD_MYC_ONCOGENIC_SIGNATURE 206117All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
CONRAD_STEM_CELL 3927All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway


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