Gene Page: GMPR

Summary ?
GeneID2766
SymbolGMPR
SynonymsGMPR 1|GMPR1
Descriptionguanosine monophosphate reductase
ReferenceMIM:139265|HGNC:HGNC:4376|Ensembl:ENSG00000137198|HPRD:00754|Vega:OTTHUMG00000014302
Gene typeprotein-coding
Map location6p23
Pascal p-value0.018
Sherlock p-value0.762
Fetal beta-1.163
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.0159 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg19001871616238672GMPR7.25E-9-0.0293.62E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10497012chr2148319726GMPR27660.16trans
rs1981925chr434348578GMPR27660.09trans
rs12663450chr638135729GMPR27660.18trans
rs4909503chr8136671520GMPR27660.13trans
rs10958899chr910128700GMPR27660.05trans
rs10958907chr910131580GMPR27660.05trans
rs1322159chr910132695GMPR27660.06trans
rs10958910chr910134759GMPR27660.04trans
rs16958826chr1682925548GMPR27660.13trans
rs11080561chr1812257229GMPR27661.045E-4trans
rs7268640chr2047150267GMPR27660.02trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LRWD10.930.94
MRPS20.930.92
GPR172A0.930.94
WDR540.920.93
PTOV10.920.93
POLD20.910.93
EMD0.910.92
WDR180.910.92
ZNF4080.910.92
TARBP20.910.92
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.27-0.72-0.82
AF347015.33-0.71-0.81
MT-CO2-0.71-0.79
AF347015.8-0.70-0.80
AF347015.31-0.70-0.78
MT-CYB-0.68-0.79
AF347015.15-0.67-0.78
AF347015.2-0.66-0.80
AF347015.26-0.65-0.79
C5orf53-0.63-0.68

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003920GMP reductase activityTAS9813009 
GO:0016491oxidoreductase activityIEA-
GO:0030955potassium ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0009117nucleotide metabolic processIEA-
GO:0009409response to coldTAS9813009 
GO:0055114oxidation reductionIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PURINE METABOLISM 15996All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF NUCLEOTIDES 7245All SZGR 2.0 genes in this pathway
REACTOME PURINE SALVAGE 1311All SZGR 2.0 genes in this pathway
REACTOME PURINE METABOLISM 3324All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367220All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182110All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187115All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK UP 214144All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA LOH REGIONS 4430All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
DER IFN ALPHA RESPONSE UP 7448All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP 205126All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN 169112All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203130All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246180All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390242All SZGR 2.0 genes in this pathway
BROWNE INTERFERON RESPONSIVE GENES 6844All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 12089All SZGR 2.0 genes in this pathway
SCHLINGEMANN SKIN CARCINOGENESIS TPA DN 2915All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR UP 9365All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268157All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR UP 4739All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP 295149All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439257All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246152All SZGR 2.0 genes in this pathway
EHLERS ANEUPLOIDY DN 128All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293203All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
LOPEZ MESOTHELIOMA SURVIVAL UP 119All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 UP 13485All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387225All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP 266142All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE UP 11665All SZGR 2.0 genes in this pathway