SZGR2

Summary ?

GeneID	2784
Symbol	GNB3
Synonyms	-
Description	G protein subunit beta 3
Reference	MIM:139130\|HGNC:HGNC:4400\|Ensembl:ENSG00000111664\|HPRD:00743\|Vega:OTTHUMG00000168517
Gene type	protein-coding
Map location	12p13
Pascal p-value	0.205
Sherlock p-value	0.888
eGene	Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans Meta
Support	CANABINOID DOPAMINE G-PROTEIN RELAY METABOTROPIC GLUTAMATE RECEPTOR SEROTONIN

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association	A combined odds ratio method (Sun et al. 2008), association studies	1	Link to SZGene
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs3917788	chr1	169568718	GNB3	2784		0.18		trans
rs6666913	chr1	237092144	GNB3	2784		2.115E-4		trans
rs16865199	chr2	6621910	GNB3	2784		0.18		trans
rs9870631	chr3	29583547	GNB3	2784		0.12		trans
rs2324466	chr3	76100753	GNB3	2784		0		trans
rs17013713	chr3	76105150	GNB3	2784		3.197E-4		trans
rs17013722	chr3	76107656	GNB3	2784		0		trans
rs17013724	chr3	76107684	GNB3	2784		0		trans
rs7644174	chr3	112722325	GNB3	2784		0.05		trans
rs9882442	chr3	173644484	GNB3	2784		0.19		trans
rs11937178	chr4	148847598	GNB3	2784		0		trans
rs11934409	chr4	148848884	GNB3	2784		0		trans
rs9986296	chr5	3199318	GNB3	2784		0		trans
rs17463444	chr5	95174483	GNB3	2784		0.11		trans
rs1030668	chr5	166876426	GNB3	2784		0.06		trans
rs992435	chr7	97050802	GNB3	2784		0.18		trans
rs8190856	chr8	18079123	GNB3	2784		0.1		trans
rs16920368	chr8	55392852	GNB3	2784		0.07		trans
rs348150	chr8	73371619	GNB3	2784		0.04		trans
rs16938220	chr8	73377940	GNB3	2784		0.04		trans
rs16908622	chr8	139231604	GNB3	2784		0.06		trans
rs4878005	chr9	89316567	GNB3	2784		0.15		trans
rs12685165	chr9	89340049	GNB3	2784		0.1		trans
rs12686427	chr9	89340546	GNB3	2784		0.1		trans
rs10119434	chr9	110944789	GNB3	2784		0.11		trans
rs10982951	chr9	118609806	GNB3	2784		0.02		trans
rs11193467	chr10	109217296	GNB3	2784		0.14		trans
rs1002405	chr11	85572958	GNB3	2784		0.05		trans
rs2069410	chr12	56364644	GNB3	2784		0.04		trans
rs17834315	chr13	37991091	GNB3	2784		0.09		trans
rs11841288	chr13	60215833	GNB3	2784		0.16		trans
rs10498433	chr14	52289530	GNB3	2784		0		trans
rs1743505	chr14	96143407	GNB3	2784		0.06		trans
rs16946913	chr15	63653889	GNB3	2784		0.1		trans
snp_a-4250222		0	GNB3	2784		0.04		trans
rs6499075	chr16	66387395	GNB3	2784		0.03		trans
rs2826625	chr21	22341050	GNB3	2784		0.12		trans
rs2826648	chr21	22362498	GNB3	2784		0.12		trans
rs9980476	chr21	22365306	GNB3	2784		0.12		trans
rs1041786	chr21	22617710	GNB3	2784		0.02		trans
rs7055735	chrX	85687566	GNB3	2784		0.06		trans
rs1129649	12	6948468	GNB3	ENSG00000111664.6	2.596E-7	0.01	-907	gtex_brain_putamen_basal
rs5440	12	6948899	GNB3	ENSG00000111664.6	2.215E-6	0.01	-476	gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AL117209.1	0.91	0.90
AP3D1	0.91	0.90
EIF4G1	0.91	0.89
GRIPAP1	0.90	0.87
MPRIP	0.89	0.90
LARP1	0.89	0.89
ANKRD11	0.89	0.90
GOLGA3	0.89	0.92
VPS53	0.89	0.88
HERC2	0.89	0.89

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.21	-0.75	-0.71
C1orf54	-0.73	-0.73
AF347015.31	-0.71	-0.66
GNG11	-0.69	-0.67
VAMP5	-0.68	-0.62
HIGD1B	-0.68	-0.63
MT-CO2	-0.67	-0.62
ENHO	-0.66	-0.60
SAT1	-0.65	-0.62
S100A13	-0.65	-0.63

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003993	acid phosphatase activity	IEA		-
GO:0004871	signal transducer activity	IEA		-
GO:0003924	GTPase activity	TAS		9425898
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS		2107550
GO:0008217	regulation of blood pressure	TAS		9425898
GO:0007165	signal transduction	IEA		-
GO:0009755	hormone-mediated signaling	EXP		12626323
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IDA		18029348

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CHEMOKINE SIGNALING PATHWAY	190	128	All SZGR 2.0 genes in this pathway
KEGG TASTE TRANSDUCTION	52	28	All SZGR 2.0 genes in this pathway
PID CONE PATHWAY	23	8	All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	205	136	All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM	120	84	All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING	78	56	All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	137	110	All SZGR 2.0 genes in this pathway
REACTOME G PROTEIN ACTIVATION	27	15	All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES	413	270	All SZGR 2.0 genes in this pathway
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	34	23	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	43	28	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS	184	116	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION	93	65	All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	25	15	All SZGR 2.0 genes in this pathway
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	88	58	All SZGR 2.0 genes in this pathway
REACTOME GLUCAGON TYPE LIGAND RECEPTORS	33	22	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS	74	56	All SZGR 2.0 genes in this pathway
REACTOME ADP SIGNALLING THROUGH P2RY1	25	16	All SZGR 2.0 genes in this pathway
REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	20	12	All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING	805	368	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS	195	114	All SZGR 2.0 genes in this pathway
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	25	15	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS	121	82	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Z SIGNALLING EVENTS	44	29	All SZGR 2.0 genes in this pathway
REACTOME G PROTEIN BETA GAMMA SIGNALLING	28	18	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL AMPLIFICATION	31	19	All SZGR 2.0 genes in this pathway
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	23	14	All SZGR 2.0 genes in this pathway
REACTOME ADP SIGNALLING THROUGH P2RY12	21	10	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	31	23	All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING	408	246	All SZGR 2.0 genes in this pathway
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	32	20	All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS	78	49	All SZGR 2.0 genes in this pathway
REACTOME AQUAPORIN MEDIATED TRANSPORT	51	34	All SZGR 2.0 genes in this pathway
REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	19	11	All SZGR 2.0 genes in this pathway
REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION	22	14	All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	19	12	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	44	30	All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	25	17	All SZGR 2.0 genes in this pathway
REACTOME GABA B RECEPTOR ACTIVATION	38	26	All SZGR 2.0 genes in this pathway
REACTOME GABA RECEPTOR ACTIVATION	52	40	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME POTASSIUM CHANNELS	98	68	All SZGR 2.0 genes in this pathway
REACTOME INWARDLY RECTIFYING K CHANNELS	31	20	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
KORKOLA SEMINOMA UP	44	27	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN	378	231	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP	329	196	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION UP	38	25	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC UP	62	38	All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP	203	130	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP	244	165	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP	105	73	All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN	108	68	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
ZHAN VARIABLE EARLY DIFFERENTIATION GENES UP	15	9	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL UP	105	46	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-221/222	481	487	1A	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	481	487	1A	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: GNB3