SZGR2

Summary ?

GeneID	28996
Symbol	HIPK2
Synonyms	PRO0593
Description	homeodomain interacting protein kinase 2
Reference	MIM:606868\|HGNC:HGNC:14402\|Ensembl:ENSG00000064393\|HPRD:06039\|Vega:OTTHUMG00000157704
Gene type	protein-coding
Map location	7q34
Pascal p-value	0.006
Sherlock p-value	3.539E-5
Fetal beta	-0.935
eGene	Myers' cis & trans
Support	CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs483323	chr1	107958416	HIPK2	28996	0.07	trans
rs7340968	chr4	78961665	HIPK2	28996	0.15	trans
rs17614208	chr4	165147508	HIPK2	28996	0.19	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	-	HPRD,BioGRID	11740489
DAXX	BING2 \| DAP6 \| EAP1 \| MGC126245 \| MGC126246	death-domain associated protein	-	HPRD,BioGRID	14678985
HMGA1	HMG-R \| HMGA1A \| HMGIY \| MGC12816 \| MGC4242 \| MGC4854	high mobility group AT-hook 1	-	HPRD	11593421
NKX2-1	BCH \| BHC \| NK-2 \| NKX2.1 \| NKX2A \| TEBP \| TITF1 \| TTF-1 \| TTF1	NK2 homeobox 1	-	HPRD,BioGRID	11438542
NKX2-5	CHNG5 \| CSX \| CSX1 \| NKX2.5 \| NKX2E \| NKX4-1	NK2 transcription factor related, locus 5 (Drosophila)	-	HPRD	9748262
NLK	DKFZp761G1211 \| FLJ21033	nemo-like kinase	-	HPRD	15082531
PTCH1	BCNS \| FLJ26746 \| FLJ42602 \| HPE7 \| NBCCS \| PTC \| PTC1 \| PTCH \| PTCH11	patched homolog 1 (Drosophila)	-	HPRD	12874272
RANBP9	RANBPM	RAN binding protein 9	The nuclear protein kinase HIPK2 interacts with the Ran binding protein RanBPM	BIND	12220523
RANBP9	RANBPM	RAN binding protein 9	-	HPRD,BioGRID	12220523
SKI	SKV	v-ski sarcoma viral oncogene homolog (avian)	-	HPRD,BioGRID	12874272
SMAD1	BSP1 \| JV4-1 \| JV41 \| MADH1 \| MADR1	SMAD family member 1	-	HPRD,BioGRID	12874272
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD family member 2	-	HPRD,BioGRID	12874272
SMAD3	DKFZp586N0721 \| DKFZp686J10186 \| HSPC193 \| HsT17436 \| JV15-2 \| MADH3 \| MGC60396	SMAD family member 3	Reconstituted Complex	BioGRID	12874272
SP100	DKFZp686E07254 \| FLJ00340 \| FLJ34579	SP100 nuclear antigen	-	HPRD,BioGRID	14647468
SUMO1	DAP-1 \| GMP1 \| OFC10 \| PIC1 \| SENP2 \| SMT3 \| SMT3C \| SMT3H3 \| SUMO-1 \| UBL1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	SUMO-1 interacts with HIPK2.	BIND	14609633
SUMO1	DAP-1 \| GMP1 \| OFC10 \| PIC1 \| SENP2 \| SMT3 \| SMT3C \| SMT3H3 \| SUMO-1 \| UBL1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	-	HPRD,BioGRID	14609633
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Affinity Capture-Western Biochemical Activity Reconstituted Complex Two-hybrid	BioGRID	11740489 \|11925430
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	HIPK2 does not interact directly with tumour suppressor protein p53 but enhances p53 activity and p53 expression or stability	BIND	11532197
TP53INP1	DKFZp434M1317 \| FLJ22139 \| SIP \| TP53DINP1 \| TP53INP1A \| TP53INP1B \| Teap \| p53DINP1	tumor protein p53 inducible nuclear protein 1	-	HPRD,BioGRID	12851404
TP63	AIS \| B(p51A) \| B(p51B) \| EEC3 \| KET \| LMS \| NBP \| OFC8 \| RHS \| SHFM4 \| TP53CP \| TP53L \| TP73L \| p40 \| p51 \| p53CP \| p63 \| p73H \| p73L	tumor protein p63	-	HPRD,BioGRID	11925430
TP73	P73	tumor protein p73	-	HPRD,BioGRID	11925430
TRADD	Hs.89862 \| MGC11078	TNFRSF1A-associated via death domain	-	HPRD,BioGRID	11032752
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	Ubc9 with HIPK2.	BIND	14609633
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	Two-hybrid	BioGRID	14609633
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	-	HPRD	10535925

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID CMYB PATHWAY	84	61	All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY	59	50	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL DN	91	53	All SZGR 2.0 genes in this pathway
WILCOX RESPONSE TO PROGESTERONE DN	66	44	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP	485	293	All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP	372	227	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP	404	246	All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP	456	228	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP	544	308	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP	431	237	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN	805	505	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA DN	77	52	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP	552	347	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP	211	136	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN	196	131	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP	197	135	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2	127	92	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
SUNG METASTASIS STROMA DN	54	34	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TROGLITAZONE UP	25	15	All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF TROGLITAZONE DN	42	24	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN	148	102	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN	298	200	All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF DN	84	50	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS UP	85	50	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6	189	112	All SZGR 2.0 genes in this pathway
BILD CTNNB1 ONCOGENIC SIGNATURE	82	52	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P7	90	52	All SZGR 2.0 genes in this pathway
GAVIN IL2 RESPONSIVE FOXP3 TARGETS UP	19	12	All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP	74	51	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN	92	64	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN	540	340	All SZGR 2.0 genes in this pathway
BREDEMEYER RAG SIGNALING NOT VIA ATM DN	57	34	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE DN	138	99	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN	222	147	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2	182	102	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR DN	36	19	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT	572	352	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A	898	516	All SZGR 2.0 genes in this pathway
BILANGES SERUM SENSITIVE GENES	90	54	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS UP	169	105	All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 UP	115	73	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS	220	133	All SZGR 2.0 genes in this pathway
BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE	151	86	All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE UP	116	65	All SZGR 2.0 genes in this pathway

Gene Page: HIPK2