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| GeneID |
2901
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| Symbol |
GRIK5
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| Synonyms |
EAA2|GRIK2|KA2
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| Description |
glutamate receptor, ionotropic, kainate 5 |
| See related |
HGNC:4583|MIM:600283|Ensembl:ENSG00000105737|HPRD:02614| |
| Locus tag |
- |
| Gene type |
protein-coding |
| Map location |
19q13.2 |
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| Gene set name |
Method of gene set |
Evidence |
Info |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia] | Click to show detail | | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 9 | | | Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0192 | |
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| General Gene Expression (microarray) ? |
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| Gene Expression in Brain Regions (new) |
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| Top co-expressed genes in Brain Regions (new) |
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| Gene | Pearson's Correlation | Spearman's Correlation | | |
| Top 10 positively co-expressed genes |
| C1orf201 | 0.80 | 0.83 | | |
| GRIA4 | 0.80 | 0.81 | | |
| STYK1 | 0.78 | 0.83 | | |
| LIG4 | 0.77 | 0.79 | | |
| GPR61 | 0.76 | 0.84 | | |
| WBSCR17 | 0.76 | 0.78 | | |
| NALCN | 0.76 | 0.84 | | |
| KCNC4 | 0.75 | 0.80 | | |
| CYB561 | 0.75 | 0.78 | | |
| PDGFB | 0.75 | 0.74 | | |
Top 10 negatively co-expressed genes | | SIGIRR | -0.37 | -0.45 | | |
| RPL18 | -0.36 | -0.46 | | |
| RPS16P1 | -0.36 | -0.50 | | |
| RPL24 | -0.36 | -0.41 | | |
| CSRP2 | -0.36 | -0.39 | | |
| RPL38 | -0.35 | -0.50 | | |
| UXT | -0.35 | -0.38 | | |
| RPL28 | -0.35 | -0.47 | | |
| RPL35 | -0.35 | -0.44 | | |
| RPL31 | -0.35 | -0.40 | | |
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| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0005234 | extracellular-glutamate-gated ion channel activity | IEA | glutamate (GO term level: 11) | - |
| GO:0015277 | kainate selective glutamate receptor activity | IDA | glutamate (GO term level: 8) | 1321949 |
| GO:0004872 | receptor activity | IEA | | - |
| GO:0005515 | protein binding | IEA | | - |
| GO:0005216 | ion channel activity | IEA | | - |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0060079 | regulation of excitatory postsynaptic membrane potential | IEA | neuron, Synap (GO term level: 10) | - |
| GO:0031630 | regulation of synaptic vesicle fusion to presynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 11) | - |
| GO:0007268 | synaptic transmission | NAS | neuron, Synap, Neurotransmitter (GO term level: 6) | - |
| GO:0035249 | synaptic transmission, glutamatergic | IEA | neuron, glutamate, Synap, Neurotransmitter (GO term level: 8) | - |
| GO:0006811 | ion transport | IEA | | - |
| GO:0042391 | regulation of membrane potential | IEA | | - |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0042734 | presynaptic membrane | IEA | neuron, axon, Synap (GO term level: 5) | - |
| GO:0032983 | kainate selective glutamate receptor complex | IEA | glutamate (GO term level: 10) | - |
| GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
| GO:0045202 | synapse | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
| GO:0005624 | membrane fraction | IEA | | - |
| GO:0016021 | integral to membrane | NAS | | - |
| GO:0005886 | plasma membrane | IEA | | - |
| GO:0030054 | cell junction | IEA | | - |
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- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.
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