Gene Page: HLA-DRA

Summary
GeneID  3122
Symbol  HLA-DRA
Synonyms  HLA-DRA1
Description  major histocompatibility complex, class II, DR alpha
See related  HGNC:4947|MIM:142860|Ensembl:ENSG00000204287|HPRD:00833|
Locus tag  DASS-397D15.1
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CD590.780.76
TMBIM10.770.80
HERC60.750.76
CTBS0.750.72
HIBADH0.740.76
CSRP10.740.78
MRO0.740.81
ME10.740.77
GRAMD30.730.80
HSPB80.730.79
Top 10 negatively co-expressed genes
KIAA1949-0.59-0.57
NKIRAS2-0.58-0.55
ZNF311-0.58-0.61
TUBB2B-0.58-0.59
ZNF821-0.58-0.58
SH2B2-0.58-0.67
MARCKSL1-0.57-0.59
PKN1-0.57-0.60
GMIP-0.57-0.56
MPP3-0.57-0.55
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0032395MHC class II receptor activityNAS6304715 |6812963 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIIEA-
GO:0006955immune responseIEA-
GO:0006955immune responseNAS6304715 |6812963 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005764lysosomeIDA8890155 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneEXP11048639 |11827988 |15489916 
|17652306 
GO:0005886plasma membraneIDA8890155 
GO:0005887integral to plasma membraneNAS6304715 |6812963 
GO:0042613MHC class II protein complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD63LAMP-3 | ME491 | MLA1 | OMA81H | TSPAN30CD63 molecule-HPRD,BioGRID9759843 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 molecule-HPRD,BioGRID9759843 
HLA-DMAD6S222E | DMA | HLADM | RING6major histocompatibility complex, class II, DM alpha-HPRD,BioGRID8574855 |9371817 
|11070170 
HLA-DMBD6S221E | RING7major histocompatibility complex, class II, DM beta-HPRD7648393 |8574855 
|8920889 |9371817 
|10716924 |12932352 
Affinity Capture-Western
in vitro
in vivo		BioGRID7648393 |8574855 
|8920889 |10716924 
|12932352 
HLA-DRB1DRB1 | FLJ76359 | HLA-DR1B | HLA-DRB | HLA-DRB1* | SS1major histocompatibility complex, class II, DR beta 1-HPRD9354468 
HLA-DRB5-major histocompatibility complex, class II, DR beta 5-HPRD,BioGRID12244309 
MBPMGC99675myelin basic protein-HPRD,BioGRID9782128 
PRPF40BHYPCPRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)-HPRD9700202 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_ADHESION_MOLECULES_CAMS 13493All SZGR genes in this pathway
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 8965All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 4836All SZGR genes in this pathway
KEGG_TYPE_I_DIABETES_MELLITUS 4438All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_ASTHMA 3025All SZGR genes in this pathway
KEGG_AUTOIMMUNE_THYROID_DISEASE 5349All SZGR genes in this pathway
KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 140100All SZGR genes in this pathway
KEGG_ALLOGRAFT_REJECTION 3834All SZGR genes in this pathway
KEGG_GRAFT_VERSUS_HOST_DISEASE 4231All SZGR genes in this pathway
KEGG_VIRAL_MYOCARDITIS 7358All SZGR genes in this pathway
BIOCARTA_CSK_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_ASBCELL_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_BLYMPHOCYTE_PATHWAY 118All SZGR genes in this pathway
BIOCARTA_INFLAM_PATHWAY 2924All SZGR genes in this pathway
BIOCARTA_IL5_PATHWAY 109All SZGR genes in this pathway
BIOCARTA_TCRA_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_TH1TH2_PATHWAY 1914All SZGR genes in this pathway
BIOCARTA_CTLA4_PATHWAY 2118All SZGR genes in this pathway
PID_TCR_PATHWAY 6651All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_IL12_STAT4_PATHWAY 3329All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
BIDUS_METASTASIS_DN 16193All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_4 169All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_CIS 12877All SZGR genes in this pathway
WIELAND_UP_BY_HBV_INFECTION 10166All SZGR genes in this pathway
IIZUKA_LIVER_CANCER_EARLY_RECURRENCE 1110All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_DN 12986All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_DN 184132All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_DN 5334All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
GAURNIER_PSMD4_TARGETS 7355All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
WEST_ADRENOCORTICAL_CARCINOMA_VS_ADENOMA_DN 2418All SZGR genes in this pathway
BREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_DN 5734All SZGR genes in this pathway
BEIER_GLIOMA_STEM_CELL_DN 6642All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP 10767All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_DN 4934All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
VALK_AML_CLUSTER_6 3322All SZGR genes in this pathway
BUDHU_LIVER_CANCER_METASTASIS_UP 107All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP 7646All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2 182102All SZGR genes in this pathway
GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB 14583All SZGR genes in this pathway
PHESSE_TARGETS_OF_APC_AND_MBD2_UP 2014All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
KIM_GLIS2_TARGETS_UP 8461All SZGR genes in this pathway


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