Gene Page: HMGA1

Summary
GeneID  3159
Symbol  HMGA1
Synonyms  HMG-R|HMGA1A|HMGIY|MGC12816|MGC4242|MGC4854
Description  high mobility group AT-hook 1
See related  HGNC:5010|MIM:600701|Ensembl:ENSG00000137309|HPRD:02829|
Locus tag  -
Gene type  protein-coding
Map location  6p21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0003680AT DNA bindingTAS10428834 
GO:0003700transcription factor activityIMP10428834 
GO:0042975peroxisome proliferator activated receptor bindingIDA10428834 
GO:0030374ligand-dependent nuclear receptor transcription coactivator activityIMP10428834 
GO:0046965retinoid X receptor bindingIDA10428834 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006337nucleosome disassemblyTAS10428834 
GO:0006345loss of chromatin silencingTAS10428834 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006355regulation of transcription, DNA-dependentTAS10871404 
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayNAS15609325 
GO:0006461protein complex assemblyTAS10428834 
GO:0006268DNA unwinding during replicationNAS10428834 
GO:0019047provirus integrationEXP16291214 
GO:0019059initiation of viral infectionEXP12091904 
GO:0045941positive regulation of transcriptionIMP10428834 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000785chromatinIEA-
GO:0005829cytosolEXP12228227 |15479846 
GO:0005634nucleusIEA-
GO:0005667transcription factor complexTAS10428834 
GO:0005694chromosomeIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATF2CRE-BP1 | CREB2 | HB16 | MGC111558 | TREB7activating transcription factor 2-HPRD,BioGRID10357819 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD,BioGRID12665574 
ELF1-E74-like factor 1 (ets domain transcription factor)Reconstituted ComplexBioGRID7862168 
EWSR1EWSEwing sarcoma breakpoint region 1Two-hybridBioGRID16189514 
HIPK2DKFZp686K02111 | FLJ23711 | PRO0593homeodomain interacting protein kinase 2-HPRD11593421 
INSRCD220 | HHF5insulin receptorHMGA1 interacts with INSR locus.BIND15924147 
IRF1IRF-1 | MARinterferon regulatory factor 1-HPRD,BioGRID10357819 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID10357819 
NFYACBF-A | CBF-B | FLJ11236 | HAP2 | NF-YAnuclear transcription factor Y, alpha-HPRD,BioGRID9388234 
POU3F1OCT6 | OTF6 | SCIPPOU class 3 homeobox 1-HPRD,BioGRID7791781 
RNF4RES4-26 | SNURFring finger protein 4-HPRD10713105 
SP1-Sp1 transcription factor-HPRD,BioGRID12665574 
SUFUPRO1280 | SUFUH | SUFUXLsuppressor of fused homolog (Drosophila)-HPRD14611647 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_IL4_2PATHWAY 6543All SZGR genes in this pathway
PID_MYC_ACTIV_PATHWAY 7962All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HIV_LIFE_CYCLE 12569All SZGR genes in this pathway
REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE 218All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS 3321All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_UP 238144All SZGR genes in this pathway
SENESE_HDAC2_TARGETS_UP 11466All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_UP 14699All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_UP 164122All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
MARKS_ACETYLATED_NON_HISTONE_PROTEINS 159All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_15 139All SZGR genes in this pathway
ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 14073All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_2_UP 6445All SZGR genes in this pathway
XU_HGF_SIGNALING_NOT_VIA_AKT1_48HR_UP 3520All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
OXFORD_RALA_OR_RALB_TARGETS_UP 4823All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP 10866All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
BENPORATH_ES_CORE_NINE_CORRELATED 10068All SZGR genes in this pathway
AMIT_EGF_RESPONSE_480_HELA 164118All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_DN 7543All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
SHEPARD_BMYB_TARGETS 7441All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN 185111All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_UP 205126All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
POMEROY_MEDULLOBLASTOMA_PROGNOSIS_DN 4328All SZGR genes in this pathway
SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_UP 4530All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_DN 7657All SZGR genes in this pathway
BHATTACHARYA_EMBRYONIC_STEM_CELL 8960All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_DN 8757All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP 7752All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH3_21_UP 4430All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_RESPONSE 3528All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
LINDVALL_IMMORTALIZED_BY_TERT_UP 7848All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_DN 215132All SZGR genes in this pathway
ZHOU_TNF_SIGNALING_30MIN 5436All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_UP 7757All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_16HR 4024All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
LEIN_MIDBRAIN_MARKERS 8255All SZGR genes in this pathway
LEIN_PONS_MARKERS 8959All SZGR genes in this pathway
LEIN_MEDULLA_MARKERS 8148All SZGR genes in this pathway
JEPSEN_SMRT_TARGETS 3323All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_BPA_E2 11865All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
MATZUK_MALE_REPRODUCTION_SERTOLI 2823All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
HUPER_BREAST_BASAL_VS_LUMINAL_DN 5944All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
CROONQUIST_IL6_DEPRIVATION_DN 9869All SZGR genes in this pathway
CROONQUIST_NRAS_SIGNALING_DN 7247All SZGR genes in this pathway
ZHAN_V1_LATE_DIFFERENTIATION_GENES_DN 1513All SZGR genes in this pathway
KAPOSI_LIVER_CANCER_MET_UP 1811All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP 10575All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD2_DN 4629All SZGR genes in this pathway
DANG_MYC_TARGETS_UP 143100All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN 229135All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
DELACROIX_RAR_TARGETS_UP 4833All SZGR genes in this pathway
VANOEVELEN_MYOGENESIS_SIN3A_TARGETS 220133All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98960966m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-103/107117811851A,m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-124.14354411Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-138168174m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-142-3p1551621A,m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-1434574631Ahsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-15/16/195/424/49710191025m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-196959965m8hsa-miR-196aUAGGUAGUUUCAUGUUGUUGG
hsa-miR-196bUAGGUAGUUUCCUGUUGUUGG
miR-26131713241A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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