Gene Page: ID4

Summary
GeneID  3400
Symbol  ID4
Synonyms  IDB4|bHLHb27
Description  inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
See related  HGNC:5363|MIM:600581|Ensembl:ENSG00000172201|HPRD:08995|
Locus tag  -
Gene type  protein-coding
Map location  6p22-p21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ARFIP20.890.81
PSMC40.880.83
SARS0.870.81
NSFL1C0.870.82
PMPCA0.870.81
TCF250.870.78
LCMT10.870.82
PSMD40.870.83
NDUFS20.870.79
AHSA10.870.82
Top 10 negatively co-expressed genes
AF347015.8-0.75-0.61
AF347015.2-0.74-0.61
AF347015.21-0.74-0.59
MT-CO2-0.73-0.58
AF347015.31-0.73-0.61
AF347015.33-0.73-0.62
MT-CYB-0.72-0.60
AF347015.26-0.72-0.63
AF347015.15-0.72-0.62
AF347015.27-0.71-0.63
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003714transcription corepressor activityTAS7665172 
GO:0005515protein bindingIEA-
GO:0030528transcription regulator activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentIEABrain (GO term level: 7)-
GO:0007405neuroblast proliferationIEAneuron (GO term level: 8)-
GO:0048712negative regulation of astrocyte differentiationIEAastrocyte, Glial (GO term level: 12)-
GO:0021895cerebral cortex neuron differentiationIEAneuron, Brain (GO term level: 9)-
GO:0045665negative regulation of neuron differentiationIEAneuron (GO term level: 10)-
GO:0000082G1/S transition of mitotic cell cycleIEA-
GO:0006357regulation of transcription from RNA polymerase II promoterTAS7665172 
GO:0008284positive regulation of cell proliferationIEA-
GO:0021766hippocampus developmentIEA-
GO:0045449regulation of transcriptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN 391222All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN 198110All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_LOBULAR_NORMAL_DN 6943All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_DN 9153All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP 9459All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
PAPASPYRIDONOS_UNSTABLE_ATEROSCLEROTIC_PLAQUE_DN 4329All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN 260143All SZGR genes in this pathway
SENESE_HDAC2_TARGETS_DN 13377All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_UP 164122All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_UP 162116All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_DN 6743All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_DN 228137All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP 9760All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_UP 214144All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_UP 271175All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_DN 6244All SZGR genes in this pathway
BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_UP 6045All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS 205145All SZGR genes in this pathway
BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_AND_PAX3 75All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN 164111All SZGR genes in this pathway
DAWSON_METHYLATED_IN_LYMPHOMA_TCL1 5945All SZGR genes in this pathway
SASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION 5031All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
BENPORATH_ES_CORE_NINE_CORRELATED 10068All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_6P24_P22_AMPLICON 2117All SZGR genes in this pathway
JI_METASTASIS_REPRESSED_BY_STK11 2717All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 6647All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
HASLINGER_B_CLL_WITH_13Q14_DELETION 2418All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
YEGNASUBRAMANIAN_PROSTATE_CANCER 12860All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
GAUTSCHI_SRC_SIGNALING 86All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
LE_SKI_TARGETS_DN 86All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN 6746All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
LOPEZ_EPITHELIOID_MESOTHELIOMA 1711All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_1HR_UP 3426All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2061401461Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-10939945m8hsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-1015865921Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-1445855921A,m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-1493541m8hsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-188130813141Ahsa-miR-188CAUCCCUUGCAUGGUGGAGGGU
miR-19187193m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-192/21599610021Ahsa-miR-192CUGACCUAUGAAUUGACAGCC
hsa-miR-215AUGACCUAUGAAUUGACAGAC
miR-1944945001Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-203.15225291A,m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-272462521Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-3203903961Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-3425595661A,m8hsa-miR-342brainUCUCACACAGAAAUCGCACCCGUC
miR-3745935991Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-486937943m8hsa-miR-486UCCUGUACUGAGCUGCCCCGAG
miR-5434914981A,m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-912011207m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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