Gene Page: IGF2R
Summary ?
GeneID | 3482 |
Symbol | IGF2R |
Synonyms | CD222|CI-M6PR|CIMPR|M6P-R|M6P/IGF2R|MPR 300|MPR1|MPR300|MPRI |
Description | insulin like growth factor 2 receptor |
Reference | MIM:147280|HGNC:HGNC:5467|HPRD:00928| |
Gene type | protein-coding |
Map location | 6q26 |
Pascal p-value | 0.248 |
Fetal beta | 0.06 |
DMG | 1 (# studies) |
Support | Ascano FMRP targets |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Montano_2016 | Genome-wide DNA methylation analysis | This dataset includes 172 replicated associations between CpGs with schizophrenia. | 2 |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg12754982 | 6 | 160409942 | IGF2R | 1.86E-4 | 0.008 | 0.152 | DMG:Montano_2016 |
cg23344523 | 6 | 160380572 | IGF2R | 3.6E-4 | 0.006 | 0.193 | DMG:Montano_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005010 | insulin-like growth factor receptor activity | TAS | 10799489 | |
GO:0004872 | receptor activity | TAS | 7753549 | |
GO:0005515 | protein binding | IEA | - | |
GO:0005520 | insulin-like growth factor binding | IEA | - | |
GO:0005215 | transporter activity | IEA | - | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0007165 | signal transduction | TAS | 7753549 | |
GO:0006810 | transport | IEA | - | |
GO:0006898 | receptor-mediated endocytosis | TAS | 10799489 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005634 | nucleus | IEA | - | |
GO:0005641 | nuclear envelope lumen | IEA | - | |
GO:0005737 | cytoplasm | IEA | - | |
GO:0005765 | lysosomal membrane | IEA | - | |
GO:0005768 | endosome | IDA | 15078902 | |
GO:0016020 | membrane | IEA | - | |
GO:0005887 | integral to plasma membrane | TAS | 10799489 | |
GO:0030140 | trans-Golgi network transport vesicle | IDA | 15078902 |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
AGA | AGU | ASRG | GA | aspartylglucosaminidase | - | HPRD | 9362483 |
CREG1 | CREG | cellular repressor of E1A-stimulated genes 1 | - | HPRD,BioGRID | 12934103 |
CTSD | CLN10 | CPSD | MGC2311 | cathepsin D | CTSD (CD) interacts with IGF2R (MPR300). | BIND | 15258139 |
GGA1 | - | golgi associated, gamma adaptin ear containing, ARF binding protein 1 | - | HPRD | 11387475 |11390366 |
GGA2 | FLJ20966 | KIAA1080 | VEAR | golgi associated, gamma adaptin ear containing, ARF binding protein 2 | - | HPRD | 11387476 |
GGA2 | FLJ20966 | KIAA1080 | VEAR | golgi associated, gamma adaptin ear containing, ARF binding protein 2 | - | HPRD | 11387475 |11387476 |
GGA3 | KIAA0154 | golgi associated, gamma adaptin ear containing, ARF binding protein 3 | - | HPRD | 11387475 |
GZMB | CCPI | CGL-1 | CGL1 | CSP-B | CSPB | CTLA1 | CTSGL1 | HLP | SECT | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | - | HPRD | 11081635 |
M6PRBP1 | MGC11117 | MGC2012 | PP17 | TIP47 | mannose-6-phosphate receptor binding protein 1 | M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). | BIND | 9590177 |
M6PRBP1 | MGC11117 | MGC2012 | PP17 | TIP47 | mannose-6-phosphate receptor binding protein 1 | - | HPRD,BioGRID | 9590177 |10908666 |
M6PRBP1 | MGC11117 | MGC2012 | PP17 | TIP47 | mannose-6-phosphate receptor binding protein 1 | M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). | BIND | 10908666 |
M6PRBP1 | MGC11117 | MGC2012 | PP17 | TIP47 | mannose-6-phosphate receptor binding protein 1 | M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). | BIND | 11359012 |
M6PRBP1 | MGC11117 | MGC2012 | PP17 | TIP47 | mannose-6-phosphate receptor binding protein 1 | M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). | BIND | 12032303 |
M6PRBP1 | MGC11117 | MGC2012 | PP17 | TIP47 | mannose-6-phosphate receptor binding protein 1 | M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). | BIND | 10829017 |
M6PRBP1 | MGC11117 | MGC2012 | PP17 | TIP47 | mannose-6-phosphate receptor binding protein 1 | TIP47 interacts with CI-MPR. This interaction was modeled on a demostrated interaction between a modified synthetic peptide representing human TIP47 and CI-MPR from an unspecified species. | BIND | 15782153 |
PACS1 | FLJ10209 | KIAA1175 | phosphofurin acidic cluster sorting protein 1 | - | HPRD | 9695949 |11331585 |
PLAU | ATF | UPA | URK | UROKINASE | u-PA | plasminogen activator, urokinase | - | HPRD | 9566979 |
PLAUR | CD87 | UPAR | URKR | plasminogen activator, urokinase receptor | Reconstituted Complex | BioGRID | 9566979 |
USF1 | FCHL | FCHL1 | HYPLIP1 | MLTF | MLTFI | UEF | bHLHb11 | upstream transcription factor 1 | An unspecified isoform of USF1 interacts with IGF2R promoter. | BIND | 12857727 |
USF2 | FIP | bHLHb12 | upstream transcription factor 2, c-fos interacting | An unspecified isoform of USF2 interacts with IGF2R promoter. | BIND | 12857727 |
WISP2 | CCN5 | CT58 | CTGF-L | WNT1 inducible signaling pathway protein 2 | - | HPRD | 10358067 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG LYSOSOME | 121 | 83 | All SZGR 2.0 genes in this pathway |
REACTOME MEMBRANE TRAFFICKING | 129 | 74 | All SZGR 2.0 genes in this pathway |
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | 60 | 31 | All SZGR 2.0 genes in this pathway |
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | 53 | 27 | All SZGR 2.0 genes in this pathway |
ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
HORIUCHI WTAP TARGETS UP | 306 | 188 | All SZGR 2.0 genes in this pathway |
MULLIGHAN MLL SIGNATURE 1 UP | 380 | 236 | All SZGR 2.0 genes in this pathway |
MULLIGHAN MLL SIGNATURE 2 UP | 418 | 263 | All SZGR 2.0 genes in this pathway |
SENESE HDAC3 TARGETS UP | 501 | 327 | All SZGR 2.0 genes in this pathway |
JAATINEN HEMATOPOIETIC STEM CELL DN | 226 | 132 | All SZGR 2.0 genes in this pathway |
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP | 128 | 95 | All SZGR 2.0 genes in this pathway |
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP | 117 | 84 | All SZGR 2.0 genes in this pathway |
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS UP | 126 | 72 | All SZGR 2.0 genes in this pathway |
MARKEY RB1 CHRONIC LOF UP | 115 | 78 | All SZGR 2.0 genes in this pathway |
LANDIS ERBB2 BREAST TUMORS 65 UP | 22 | 13 | All SZGR 2.0 genes in this pathway |
LANDIS ERBB2 BREAST TUMORS 324 UP | 150 | 93 | All SZGR 2.0 genes in this pathway |
DACOSTA UV RESPONSE VIA ERCC3 DN | 855 | 609 | All SZGR 2.0 genes in this pathway |
AMUNDSON RESPONSE TO ARSENITE | 217 | 143 | All SZGR 2.0 genes in this pathway |
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP | 176 | 111 | All SZGR 2.0 genes in this pathway |
WOOD EBV EBNA1 TARGETS UP | 110 | 71 | All SZGR 2.0 genes in this pathway |
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP | 176 | 115 | All SZGR 2.0 genes in this pathway |
HADDAD B LYMPHOCYTE PROGENITOR | 293 | 193 | All SZGR 2.0 genes in this pathway |
VERHAAK AML WITH NPM1 MUTATED UP | 183 | 111 | All SZGR 2.0 genes in this pathway |
THEILGAARD NEUTROPHIL AT SKIN WOUND DN | 225 | 163 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 20HR UP | 240 | 152 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 16HR UP | 225 | 139 | All SZGR 2.0 genes in this pathway |
LINDVALL IMMORTALIZED BY TERT UP | 78 | 48 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
VERRECCHIA EARLY RESPONSE TO TGFB1 | 58 | 43 | All SZGR 2.0 genes in this pathway |
WELCSH BRCA1 TARGETS UP | 198 | 132 | All SZGR 2.0 genes in this pathway |
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN | 287 | 208 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 6HR UP | 71 | 48 | All SZGR 2.0 genes in this pathway |
WANG CISPLATIN RESPONSE AND XPC UP | 202 | 115 | All SZGR 2.0 genes in this pathway |
VERRECCHIA RESPONSE TO TGFB1 C3 | 14 | 10 | All SZGR 2.0 genes in this pathway |
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
HILLION HMGA1 TARGETS | 90 | 71 | All SZGR 2.0 genes in this pathway |
GAVIN FOXP3 TARGETS CLUSTER P7 | 90 | 52 | All SZGR 2.0 genes in this pathway |
JEPSEN SMRT TARGETS | 33 | 23 | All SZGR 2.0 genes in this pathway |
COATES MACROPHAGE M1 VS M2 DN | 78 | 44 | All SZGR 2.0 genes in this pathway |
POS RESPONSE TO HISTAMINE UP | 13 | 10 | All SZGR 2.0 genes in this pathway |
POS HISTAMINE RESPONSE NETWORK | 32 | 22 | All SZGR 2.0 genes in this pathway |
ACEVEDO LIVER CANCER DN | 540 | 340 | All SZGR 2.0 genes in this pathway |
SMID BREAST CANCER ERBB2 UP | 147 | 83 | All SZGR 2.0 genes in this pathway |
WEST ADRENOCORTICAL TUMOR UP | 294 | 199 | All SZGR 2.0 genes in this pathway |
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS | 80 | 56 | All SZGR 2.0 genes in this pathway |
YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
ZHANG TLX TARGETS 60HR UP | 293 | 203 | All SZGR 2.0 genes in this pathway |
HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
HAN SATB1 TARGETS DN | 442 | 275 | All SZGR 2.0 genes in this pathway |
KUROKAWA LIVER CANCER EARLY RECURRENCE DN | 7 | 6 | All SZGR 2.0 genes in this pathway |
HOSHIDA LIVER CANCER SUBCLASS S2 | 115 | 74 | All SZGR 2.0 genes in this pathway |
KYNG WERNER SYNDROM AND NORMAL AGING DN | 225 | 124 | All SZGR 2.0 genes in this pathway |
DANG REGULATED BY MYC DN | 253 | 192 | All SZGR 2.0 genes in this pathway |
WONG ADULT TISSUE STEM MODULE | 721 | 492 | All SZGR 2.0 genes in this pathway |
NAKAMURA ADIPOGENESIS LATE UP | 104 | 67 | All SZGR 2.0 genes in this pathway |
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN | 157 | 106 | All SZGR 2.0 genes in this pathway |
CHYLA CBFA2T3 TARGETS DN | 242 | 146 | All SZGR 2.0 genes in this pathway |
JOHNSTONE PARVB TARGETS 3 UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
KASLER HDAC7 TARGETS 1 DN | 17 | 13 | All SZGR 2.0 genes in this pathway |
LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |
IKEDA MIR30 TARGETS DN | 27 | 24 | All SZGR 2.0 genes in this pathway |
KATSANOU ELAVL1 TARGETS UP | 169 | 105 | All SZGR 2.0 genes in this pathway |
SERVITJA LIVER HNF1A TARGETS UP | 135 | 96 | All SZGR 2.0 genes in this pathway |
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN | 106 | 77 | All SZGR 2.0 genes in this pathway |
BRIDEAU IMPRINTED GENES | 63 | 47 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-124.1 | 998 | 1004 | 1A | hsa-miR-124a | UUAAGGCACGCGGUGAAUGCCA |
miR-15/16/195/424/497 | 318 | 324 | m8 | hsa-miR-15abrain | UAGCAGCACAUAAUGGUUUGUG |
hsa-miR-16brain | UAGCAGCACGUAAAUAUUGGCG | ||||
hsa-miR-15bbrain | UAGCAGCACAUCAUGGUUUACA | ||||
hsa-miR-195SZ | UAGCAGCACAGAAAUAUUGGC | ||||
hsa-miR-424 | CAGCAGCAAUUCAUGUUUUGAA | ||||
hsa-miR-497 | CAGCAGCACACUGUGGUUUGU | ||||
miR-185 | 372 | 378 | m8 | hsa-miR-185brain | UGGAGAGAAAGGCAGUUC |
miR-19 | 1005 | 1012 | 1A,m8 | hsa-miR-19a | UGUGCAAAUCUAUGCAAAACUGA |
hsa-miR-19b | UGUGCAAAUCCAUGCAAAACUGA | ||||
miR-204/211 | 114 | 121 | 1A,m8 | hsa-miR-204brain | UUCCCUUUGUCAUCCUAUGCCU |
hsa-miR-211 | UUCCCUUUGUCAUCCUUCGCCU | ||||
miR-224 | 1017 | 1024 | 1A,m8 | hsa-miR-224 | CAAGUCACUAGUGGUUCCGUUUA |
miR-30-5p | 177 | 184 | 1A,m8 | hsa-miR-30a-5p | UGUAAACAUCCUCGACUGGAAG |
hsa-miR-30cbrain | UGUAAACAUCCUACACUCUCAGC | ||||
hsa-miR-30dSZ | UGUAAACAUCCCCGACUGGAAG | ||||
hsa-miR-30bSZ | UGUAAACAUCCUACACUCAGCU | ||||
hsa-miR-30e-5p | UGUAAACAUCCUUGACUGGA | ||||
miR-381 | 1270 | 1276 | 1A | hsa-miR-381 | UAUACAAGGGCAAGCUCUCUGU |
miR-542-5p | 654 | 660 | 1A | hsa-miR-542-5p | UCGGGGAUCAUCAUGUCACGAG |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.