SZGR2

Summary ?

GeneID	3482
Symbol	IGF2R
Synonyms	CD222\|CI-M6PR\|CIMPR\|M6P-R\|M6P/IGF2R\|MPR 300\|MPR1\|MPR300\|MPRI
Description	insulin like growth factor 2 receptor
Reference	MIM:147280\|HGNC:HGNC:5467\|HPRD:00928\|
Gene type	protein-coding
Map location	6q26
Pascal p-value	0.248
Fetal beta	0.06
DMG	1 (# studies)
Support	Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Montano_2016	Genome-wide DNA methylation analysis	This dataset includes 172 replicated associations between CpGs with schizophrenia.	2
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg12754982	6	160409942	IGF2R	1.86E-4	0.008	0.152	DMG:Montano_2016
cg23344523	6	160380572	IGF2R	3.6E-4	0.006	0.193	DMG:Montano_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005010	insulin-like growth factor receptor activity	TAS		10799489
GO:0004872	receptor activity	TAS		7753549
GO:0005515	protein binding	IEA		-
GO:0005520	insulin-like growth factor binding	IEA		-
GO:0005215	transporter activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007165	signal transduction	TAS		7753549
GO:0006810	transport	IEA		-
GO:0006898	receptor-mediated endocytosis	TAS		10799489
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-
GO:0005641	nuclear envelope lumen	IEA		-
GO:0005737	cytoplasm	IEA		-
GO:0005765	lysosomal membrane	IEA		-
GO:0005768	endosome	IDA		15078902
GO:0016020	membrane	IEA		-
GO:0005887	integral to plasma membrane	TAS		10799489
GO:0030140	trans-Golgi network transport vesicle	IDA		15078902

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AGA	AGU \| ASRG \| GA	aspartylglucosaminidase	-	HPRD	9362483
CREG1	CREG	cellular repressor of E1A-stimulated genes 1	-	HPRD,BioGRID	12934103
CTSD	CLN10 \| CPSD \| MGC2311	cathepsin D	CTSD (CD) interacts with IGF2R (MPR300).	BIND	15258139
GGA1	-	golgi associated, gamma adaptin ear containing, ARF binding protein 1	-	HPRD	11387475 \|11390366
GGA2	FLJ20966 \| KIAA1080 \| VEAR	golgi associated, gamma adaptin ear containing, ARF binding protein 2	-	HPRD	11387476
GGA2	FLJ20966 \| KIAA1080 \| VEAR	golgi associated, gamma adaptin ear containing, ARF binding protein 2	-	HPRD	11387475 \|11387476
GGA3	KIAA0154	golgi associated, gamma adaptin ear containing, ARF binding protein 3	-	HPRD	11387475
GZMB	CCPI \| CGL-1 \| CGL1 \| CSP-B \| CSPB \| CTLA1 \| CTSGL1 \| HLP \| SECT	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	-	HPRD	11081635
M6PRBP1	MGC11117 \| MGC2012 \| PP17 \| TIP47	mannose-6-phosphate receptor binding protein 1	M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).	BIND	9590177
M6PRBP1	MGC11117 \| MGC2012 \| PP17 \| TIP47	mannose-6-phosphate receptor binding protein 1	-	HPRD,BioGRID	9590177 \|10908666
M6PRBP1	MGC11117 \| MGC2012 \| PP17 \| TIP47	mannose-6-phosphate receptor binding protein 1	M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).	BIND	10908666
M6PRBP1	MGC11117 \| MGC2012 \| PP17 \| TIP47	mannose-6-phosphate receptor binding protein 1	M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).	BIND	11359012
M6PRBP1	MGC11117 \| MGC2012 \| PP17 \| TIP47	mannose-6-phosphate receptor binding protein 1	M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).	BIND	12032303
M6PRBP1	MGC11117 \| MGC2012 \| PP17 \| TIP47	mannose-6-phosphate receptor binding protein 1	M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).	BIND	10829017
M6PRBP1	MGC11117 \| MGC2012 \| PP17 \| TIP47	mannose-6-phosphate receptor binding protein 1	TIP47 interacts with CI-MPR. This interaction was modeled on a demostrated interaction between a modified synthetic peptide representing human TIP47 and CI-MPR from an unspecified species.	BIND	15782153
PACS1	FLJ10209 \| KIAA1175	phosphofurin acidic cluster sorting protein 1	-	HPRD	9695949 \|11331585
PLAU	ATF \| UPA \| URK \| UROKINASE \| u-PA	plasminogen activator, urokinase	-	HPRD	9566979
PLAUR	CD87 \| UPAR \| URKR	plasminogen activator, urokinase receptor	Reconstituted Complex	BioGRID	9566979
USF1	FCHL \| FCHL1 \| HYPLIP1 \| MLTF \| MLTFI \| UEF \| bHLHb11	upstream transcription factor 1	An unspecified isoform of USF1 interacts with IGF2R promoter.	BIND	12857727
USF2	FIP \| bHLHb12	upstream transcription factor 2, c-fos interacting	An unspecified isoform of USF2 interacts with IGF2R promoter.	BIND	12857727
WISP2	CCN5 \| CT58 \| CTGF-L	WNT1 inducible signaling pathway protein 2	-	HPRD	10358067

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG LYSOSOME	121	83	All SZGR 2.0 genes in this pathway
REACTOME MEMBRANE TRAFFICKING	129	74	All SZGR 2.0 genes in this pathway
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	60	31	All SZGR 2.0 genes in this pathway
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	53	27	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP	306	188	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP	380	236	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP	418	263	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN	226	132	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP	128	95	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP	117	84	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS UP	126	72	All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP	115	78	All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 65 UP	22	13	All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP	150	93	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE	217	143	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP	176	111	All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP	110	71	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP	176	115	All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR	293	193	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP	183	111	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP	240	152	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP	225	139	All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT UP	78	48	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
VERRECCHIA EARLY RESPONSE TO TGFB1	58	43	All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP	198	132	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN	287	208	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP	71	48	All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP	202	115	All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C3	14	10	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS	90	71	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P7	90	52	All SZGR 2.0 genes in this pathway
JEPSEN SMRT TARGETS	33	23	All SZGR 2.0 genes in this pathway
COATES MACROPHAGE M1 VS M2 DN	78	44	All SZGR 2.0 genes in this pathway
POS RESPONSE TO HISTAMINE UP	13	10	All SZGR 2.0 genes in this pathway
POS HISTAMINE RESPONSE NETWORK	32	22	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN	540	340	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER ERBB2 UP	147	83	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP	294	199	All SZGR 2.0 genes in this pathway
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS	80	56	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP	293	203	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP	395	249	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN	442	275	All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER EARLY RECURRENCE DN	7	6	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2	115	74	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN	225	124	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE UP	104	67	All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN	157	106	All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN	242	146	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP	430	288	All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 DN	17	13	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP	745	475	All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS DN	27	24	All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS UP	169	105	All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP	135	96	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN	106	77	All SZGR 2.0 genes in this pathway
BRIDEAU IMPRINTED GENES	63	47	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	998	1004	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-15/16/195/424/497	318	324	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-185	372	378	m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-19	1005	1012	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	1005	1012	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-204/211	114	121	1A,m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	114	121	1A,m8	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-224	1017	1024	1A,m8	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-30-5p	177	184	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-381	1270	1276	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-542-5p	654	660	1A	hsa-miR-542-5p	UCGGGGAUCAUCAUGUCACGAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: IGF2R