Gene Page: IL1B

Summary ?
GeneID3553
SymbolIL1B
SynonymsIL-1|IL1-BETA|IL1F2
Descriptioninterleukin 1 beta
ReferenceMIM:147720|HGNC:HGNC:5992|Ensembl:ENSG00000125538|HPRD:00985|Vega:OTTHUMG00000131344
Gene typeprotein-coding
Map location2q14
Pascal p-value0.876
Fetal beta-1.873
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_IGenome scan meta-analysisPsr: 0.0004 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00755 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17013080chr1208862652IL1B35534.485E-4trans
rs4844714chr1208874118IL1B35530trans
rs10494904chr1208883320IL1B35530trans
rs12097986chr1208883360IL1B35530trans
rs848543chr236706946IL1B35530.16trans
rs17652498chr2107381016IL1B35530.09trans
rs1374998chr2107398083IL1B35530.06trans
rs7445750chr5104331223IL1B35530.05trans
rs1498477chr115440619IL1B35530.14trans
rs1498476chr115440664IL1B35530.18trans
rs2016533chr1251366259IL1B35530.08trans
rs8072151chr1750228268IL1B35530.19trans
rs1373093chr1869804840IL1B35530trans
rs1344430chr2060099390IL1B35530.03trans
rs6639914chrX7554094IL1B35530.04trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityTAS10786823 
GO:0005149interleukin-1 receptor bindingNAS1919436 
GO:0005515protein bindingIPI9062193 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000187activation of MAPK activityIDA10748004 
GO:0001660feverIEA-
GO:0001934positive regulation of protein amino acid phosphorylationIDA10748004 
GO:0007267cell-cell signalingTAS2989698 
GO:0007165signal transductionTAS9218611 |10786823 
GO:0008285negative regulation of cell proliferationTAS3493774 
GO:0006955immune responseIEA-
GO:0006954inflammatory responseNAS1919436 
GO:0006916anti-apoptosisIDA10748004 
GO:0006915apoptosisTAS9218611 
GO:0051091positive regulation of transcription factor activityIDA10748004 
GO:0032755positive regulation of interleukin-6 productionIEA-
GO:0019221cytokine-mediated signaling pathwayIDA10748004 
GO:0030593neutrophil chemotaxisIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEA-
GO:0045080positive regulation of chemokine biosynthetic processIEA-
GO:0046330positive regulation of JNK cascadeIEA-
GO:0045410positive regulation of interleukin-6 biosynthetic processIEA-
GO:0045429positive regulation of nitric oxide biosynthetic processIDA8383325 
GO:0050900leukocyte migrationIEA-
GO:0050796regulation of insulin secretionIDA8383325 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS1919436 
GO:0005615extracellular spaceTAS3493774 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
KEGG APOPTOSIS 8862All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 10288All SZGR 2.0 genes in this pathway
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY 6247All SZGR 2.0 genes in this pathway
KEGG CYTOSOLIC DNA SENSING PATHWAY 5644All SZGR 2.0 genes in this pathway
KEGG HEMATOPOIETIC CELL LINEAGE 8860All SZGR 2.0 genes in this pathway
KEGG TYPE I DIABETES MELLITUS 4438All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE 169110All SZGR 2.0 genes in this pathway
KEGG PRION DISEASES 3528All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION 7256All SZGR 2.0 genes in this pathway
KEGG GRAFT VERSUS HOST DISEASE 4231All SZGR 2.0 genes in this pathway
BIOCARTA IL5 PATHWAY 109All SZGR 2.0 genes in this pathway
BIOCARTA NTHI PATHWAY 2420All SZGR 2.0 genes in this pathway
BIOCARTA IL1R PATHWAY 3329All SZGR 2.0 genes in this pathway
SA MMP CYTOKINE CONNECTION 159All SZGR 2.0 genes in this pathway
PID IL27 PATHWAY 2620All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY 6354All SZGR 2.0 genes in this pathway
PID IL1 PATHWAY 3428All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY 4034All SZGR 2.0 genes in this pathway
PID IL23 PATHWAY 3730All SZGR 2.0 genes in this pathway
PID ANTHRAX PATHWAY 1715All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 10786All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING 3930All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485293All SZGR 2.0 genes in this pathway
PRAMOONJAGO SOX4 TARGETS UP 5238All SZGR 2.0 genes in this pathway
CORRE MULTIPLE MYELOMA UP 7445All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN UP 184125All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244153All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233161All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL DN 8659All SZGR 2.0 genes in this pathway
PEPPER CHRONIC LYMPHOCYTIC LEUKEMIA UP 3328All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544308All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS CML DIVIDING UP 2313All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP 5733All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN 9557All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP 6647All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 UP 6446All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 12895All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN 7550All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP 12678All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN 185115All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162104All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147101All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146104All SZGR 2.0 genes in this pathway
MARKS HDAC TARGETS DN 1511All SZGR 2.0 genes in this pathway
DEBOSSCHER NFKB TARGETS REPRESSED BY GLUCOCORTICOIDS 2418All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 120 MCF10A 4328All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 6 119All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223140All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169102All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 3 DN 5932All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR DN 4130All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGG VS IGA DN 2616All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS 6648All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT UP 165100All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN 8567All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318215All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 DN 7748All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 12890All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND UP 7752All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183111All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP 10176All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245144All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE DN 10668All SZGR 2.0 genes in this pathway
JAZAERI BREAST CANCER BRCA1 VS BRCA2 UP 4928All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP 12375All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419273All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C3 2015All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A UP 8152All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253147All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE 246153All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261166All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS 245148All SZGR 2.0 genes in this pathway
WORSCHECH TUMOR REJECTION UP 5632All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
HUPER BREAST BASAL VS LUMINAL UP 5429All SZGR 2.0 genes in this pathway
CROMER TUMORIGENESIS UP 6336All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A 6752All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315201All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408276All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS KERATINOCYTE UP 9163All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP 8460All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395249All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
BUDHU LIVER CANCER METASTASIS DN 77All SZGR 2.0 genes in this pathway
SCHOEN NFKB SIGNALING 3426All SZGR 2.0 genes in this pathway
SEIKE LUNG CANCER POOR SURVIVAL 118All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS 4430All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242159All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE 15186All SZGR 2.0 genes in this pathway
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION 12881All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489314All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP 11068All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP 8654All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222159All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway