Gene Page: LRPAP1

Summary ?
GeneID4043
SymbolLRPAP1
SynonymsA2MRAP|A2RAP|HBP44|MRAP|MYP23|RAP|alpha-2-MRAP
DescriptionLDL receptor related protein associated protein 1
ReferenceMIM:104225|HGNC:HGNC:6701|HPRD:00082|
Gene typeprotein-coding
Map location4p16.3
Pascal p-value0.437
Sherlock p-value0.555
Fetal beta-1.606
eGeneCerebellar Hemisphere
Cerebellum
Frontal Cortex BA9
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EIF4EBP14E-BP1 | 4EBP1 | BP-1 | MGC4316 | PHAS-Ieukaryotic translation initiation factor 4E binding protein 1Affinity Capture-WesternBioGRID16798736 
FRAP1FLJ44809 | FRAP | FRAP2 | MTOR | RAFT1 | RAPT1FK506 binding protein 12-rapamycin associated protein 1Affinity Capture-WesternBioGRID16798736 
LDLRFH | FHClow density lipoprotein receptor-HPRD,BioGRID7822276 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD,BioGRID1374383 |1718973 
|10747918 
LRP1BLRP-DIT | LRPDITlow density lipoprotein-related protein 1B (deleted in tumors)-HPRD11384978 
LRP2DBS | gp330low density lipoprotein-related protein 2-HPRD,BioGRID7512726 
LRP8APOER2 | HSZ75190 | MCI1low density lipoprotein receptor-related protein 8, apolipoprotein e receptor-HPRD,BioGRID12899622 
POLA2FLJ21662 | FLJ37250polymerase (DNA directed), alpha 2 (70kD subunit)Two-hybridBioGRID16169070 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1Two-hybridBioGRID10783161 
RALAMGC48949 | RALv-ral simian leukemia viral oncogene homolog A (ras related)Reconstituted ComplexBioGRID11167825 
RALGDSFLJ20922 | RGF | RalGEFral guanine nucleotide dissociation stimulatorTwo-hybridBioGRID10783161 
RTN4ASY | NI220/250 | NOGO | NOGO-A | NOGOC | NSP | NSP-CL | Nbla00271 | Nbla10545 | Nogo-B | Nogo-C | RTN-X | RTN4-A | RTN4-B1 | RTN4-B2 | RTN4-Creticulon 4Two-hybridBioGRID16169070 
SORL1C11orf32 | FLJ21930 | FLJ39258 | LR11 | LRP9 | SORLA | SorLA-1 | gp250sortilin-related receptor, L(DLR class) A repeats-containing-HPRD,BioGRID8940146 |11557679 
SORT1Gp95 | NT3sortilin 1Reconstituted ComplexBioGRID9013611 
VLDLRCHRMQ1 | FLJ35024 | VLDLRCHvery low density lipoprotein receptor-HPRD7592875 |10571241 
VLDLRCHRMQ1 | FLJ35024 | VLDLRCHvery low density lipoprotein receptorReconstituted ComplexBioGRID10571241 |12899622 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID REELIN PATHWAY 2929All SZGR 2.0 genes in this pathway
PID LIS1 PATHWAY 2822All SZGR 2.0 genes in this pathway
PID HEDGEHOG 2PATHWAY 2217All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391222All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255177All SZGR 2.0 genes in this pathway
WIKMAN ASBESTOS LUNG CANCER UP 1711All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
CHOW RASSF1 TARGETS DN 2919All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
TERAMOTO OPN TARGETS CLUSTER 4 138All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE DN 9859All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176115All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX4 DN 3222All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP 175116All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163113All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482296All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T7 9863All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578341All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198128All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 181101All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227149All SZGR 2.0 genes in this pathway