Gene Page: MARCKS

Summary
GeneID  4082
Symbol  MARCKS
Synonyms  80K-L|FLJ14368|FLJ90045|MACS|MRACKS|PKCSL|PRKCSL
Description  myristoylated alanine-rich protein kinase C substrate
See related  HGNC:6759|MIM:177061|Ensembl:ENSG00000155130|HPRD:07519|
Locus tag  -
Gene type  protein-coding
Map location  6q22.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.01 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005516calmodulin bindingTAS1560845 
GO:0051015actin filament bindingTAS1560845 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIEA-
GO:0005737cytoplasmIEA-
GO:0016020membraneIEA-
GO:0005938cell cortexIEA-
GO:0015629actin cytoskeletonTAS1560845 
GO:0042585germinal vesicleIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CALM2CAMII | PHKD | PHKD2calmodulin 2 (phosphorylase kinase, delta)-HPRD,BioGRID12577052 
CTSBAPPS | CPSBcathepsin B-HPRD9295331 
NMT1NMTN-myristoyltransferase 1hNMT1 interacts with and myristoylates MARCKS.BIND10734119 
TOB1APRO6 | MGC104792 | MGC34446 | PIG49 | TOB | TROB | TROB1transducer of ERBB2, 1-HPRD,BioGRID11327693 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
BIOCARTA_CALCINEURIN_PATHWAY 2117All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE 119All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP 205140All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_DN 6849All SZGR genes in this pathway
DAVICIONI_RHABDOMYOSARCOMA_PAX_FOXO1_FUSION_DN 1511All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
PUIFFE_INVASION_INHIBITED_BY_ASCITES_UP 8251All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN 241146All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
BILBAN_B_CLL_LPL_DN 4225All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_DN 8659All SZGR genes in this pathway
DITTMER_PTHLH_TARGETS_UP 11268All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
BIDUS_METASTASIS_UP 214134All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP 177113All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_65_DN 3722All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN 172112All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_DN 14993All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
JOHANSSON_GLIOMAGENESIS_BY_PDGFB_UP 5844All SZGR genes in this pathway
IVANOV_MUTATED_IN_COLON_CANCER 139All SZGR genes in this pathway
LI_CISPLATIN_RESISTANCE_DN 3520All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_UP 8157All SZGR genes in this pathway
DIRMEIER_LMP1_RESPONSE_LATE_UP 5741All SZGR genes in this pathway
YANAGIHARA_ESX1_TARGETS 3019All SZGR genes in this pathway
WEINMANN_ADAPTATION_TO_HYPOXIA_UP 2924All SZGR genes in this pathway
WEINMANN_ADAPTATION_TO_HYPOXIA_DN 4133All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_DN 193112All SZGR genes in this pathway
SIMBULAN_UV_RESPONSE_NORMAL_DN 3327All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_ONLY_DN 4430All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
FRIDMAN_SENESCENCE_DN 136All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_UP 8657All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_DN 7543All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
BROCKE_APOPTOSIS_REVERSED_BY_IL6 14498All SZGR genes in this pathway
LE_EGR2_TARGETS_UP 10875All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS 183115All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD2_UP 4532All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_UP 183111All SZGR genes in this pathway
NGUYEN_NOTCH1_TARGETS_DN 8667All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_UP 3627All SZGR genes in this pathway
CHEN_LVAD_SUPPORT_OF_FAILING_HEART_DN 4232All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
ZHU_CMV_8_HR_DN 5340All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_DN 9867All SZGR genes in this pathway
ZHU_CMV_ALL_DN 12893All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_0HR 6348All SZGR genes in this pathway
BURTON_ADIPOGENESIS_11 5740All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D8 4029All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN 373196All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_T7 9863All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_DN 10563All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_UP 17496All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_DN 4117All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_DN 175103All SZGR genes in this pathway
DAVIES_MULTIPLE_MYELOMA_VS_MGUS_DN 2818All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_D_DN 7834All SZGR genes in this pathway
CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_DN 10265All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_B 5336All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN 245150All SZGR genes in this pathway
VANASSE_BCL2_TARGETS_DN 7450All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
HOFFMANN_IMMATURE_TO_MATURE_B_LYMPHOCYTE_DN 5036All SZGR genes in this pathway
LEE_RECENT_THYMIC_EMIGRANT 227128All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
ZHAN_V1_LATE_DIFFERENTIATION_GENES_UP 3225All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP 188121All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP 178108All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP 10575All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA3_DN 6938All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP 207143All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_9 7645All SZGR genes in this pathway
BAE_BRCA1_TARGETS_UP 7547All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_DN 11683All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN 229135All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_UP 11687All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
ALFANO_MYC_TARGETS 239156All SZGR genes in this pathway
HOLLEMAN_ASPARAGINASE_RESISTANCE_ALL_DN 2514All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
ZWANG_EGF_PERSISTENTLY_DN 6136All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1288018071Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-1387837891Ahsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-142-3p5555621A,m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-1431911971Ahsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-144961967m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-181112411301Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1824554621A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-200bc/4292933001A,m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-2053733801A,m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-218839845m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-23121012171A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-27801807m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-299-5p6556611Ahsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-30-5p5485541Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-323121012161Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-370785791m8hsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
miR-3818118171Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-4215405461Ahsa-miR-421GGCCUCAUUAAAUGUUUGUUG
miR-4911781851A,m8hsa-miR-491brainAGUGGGGAACCCUUCCAUGAGGA
miR-4954450m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-499638644m8hsa-miR-499UUAAGACUUGCAGUGAUGUUUAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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