Gene Page: MAP1B
Summary ?
GeneID | 4131 |
Symbol | MAP1B |
Synonyms | FUTSCH|MAP5|PPP1R102 |
Description | microtubule associated protein 1B |
Reference | MIM:157129|HGNC:HGNC:6836|Ensembl:ENSG00000131711|HPRD:01139|Vega:OTTHUMG00000100952 |
Gene type | protein-coding |
Map location | 5q13 |
Pascal p-value | 0.558 |
Sherlock p-value | 0.504 |
Fetal beta | 0.952 |
eGene | Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Myers' cis & trans |
Support | STRUCTURAL PLASTICITY G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_clathrin G2Cdb.human_mGluR5 G2Cdb.human_Synaptosome CompositeSet Darnell FMRP targets Ascano FMRP targets Potential synaptic genes |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias | Click to show details |
GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs16899493 | chr5 | 71836880 | MAP1B | 4131 | 0.04 | cis | ||
snp_a-2040925 | 0 | MAP1B | 4131 | 0.03 | trans | |||
rs11122162 | chr1 | 231097041 | MAP1B | 4131 | 0.06 | trans | ||
rs16843810 | chr1 | 234827318 | MAP1B | 4131 | 0.05 | trans | ||
rs11127467 | chr2 | 12993 | MAP1B | 4131 | 0 | trans | ||
rs17040095 | chr2 | 65926994 | MAP1B | 4131 | 0.17 | trans | ||
rs9813119 | chr3 | 45230566 | MAP1B | 4131 | 0.02 | trans | ||
rs192095 | chr3 | 111821862 | MAP1B | 4131 | 0.13 | trans | ||
rs16830299 | chr3 | 159090973 | MAP1B | 4131 | 0.16 | trans | ||
rs4698397 | chr4 | 15534712 | MAP1B | 4131 | 2.682E-5 | trans | ||
rs16992737 | chr4 | 36849942 | MAP1B | 4131 | 0.02 | trans | ||
rs17270544 | chr4 | 182529568 | MAP1B | 4131 | 4.888E-4 | trans | ||
rs17211786 | chr4 | 182548238 | MAP1B | 4131 | 2.69E-4 | trans | ||
rs2434733 | chr5 | 154431911 | MAP1B | 4131 | 0.01 | trans | ||
rs1494142 | chr6 | 125778157 | MAP1B | 4131 | 0.15 | trans | ||
rs6937122 | chr6 | 143694842 | MAP1B | 4131 | 0.03 | trans | ||
rs7760371 | chr6 | 143712251 | MAP1B | 4131 | 0.02 | trans | ||
rs17081113 | chr6 | 151637449 | MAP1B | 4131 | 0.08 | trans | ||
rs12112911 | chr7 | 26297444 | MAP1B | 4131 | 0.1 | trans | ||
rs868269 | chr7 | 76007808 | MAP1B | 4131 | 0.12 | trans | ||
rs7817138 | chr8 | 111140526 | MAP1B | 4131 | 0.04 | trans | ||
rs10505136 | chr8 | 111141220 | MAP1B | 4131 | 0.04 | trans | ||
rs4743895 | chr9 | 95905749 | MAP1B | 4131 | 0.19 | trans | ||
rs16919567 | chr9 | 103624176 | MAP1B | 4131 | 0.04 | trans | ||
rs7864609 | chr9 | 117884215 | MAP1B | 4131 | 0 | trans | ||
rs10818070 | chr9 | 120456494 | MAP1B | 4131 | 0.17 | trans | ||
rs7864330 | chr9 | 120469549 | MAP1B | 4131 | 0.08 | trans | ||
rs7087570 | chr10 | 19940964 | MAP1B | 4131 | 0.03 | trans | ||
rs7910314 | chr10 | 56004456 | MAP1B | 4131 | 0.03 | trans | ||
rs1236903 | chr10 | 71198993 | MAP1B | 4131 | 0.16 | trans | ||
rs3740184 | chr10 | 127356543 | MAP1B | 4131 | 0.16 | trans | ||
rs1436802 | chr10 | 128204332 | MAP1B | 4131 | 0.12 | trans | ||
rs1036454 | chr10 | 128211573 | MAP1B | 4131 | 0.11 | trans | ||
rs766095 | chr12 | 1498432 | MAP1B | 4131 | 0.01 | trans | ||
rs7135241 | chr12 | 95163565 | MAP1B | 4131 | 0 | trans | ||
rs11110940 | chr12 | 102054842 | MAP1B | 4131 | 0.02 | trans | ||
rs11110942 | chr12 | 102055094 | MAP1B | 4131 | 0.09 | trans | ||
rs10860768 | chr12 | 102069497 | MAP1B | 4131 | 0 | trans | ||
rs12230291 | chr12 | 102100263 | MAP1B | 4131 | 3.336E-4 | trans | ||
snp_a-4249110 | 0 | MAP1B | 4131 | 3.336E-4 | trans | |||
rs11111009 | chr12 | 102160626 | MAP1B | 4131 | 3.336E-4 | trans | ||
rs10860798 | chr12 | 102251472 | MAP1B | 4131 | 0.12 | trans | ||
rs17032130 | chr12 | 102331171 | MAP1B | 4131 | 3.336E-4 | trans | ||
rs17032134 | chr12 | 102331946 | MAP1B | 4131 | 3.336E-4 | trans | ||
rs11111120 | chr12 | 102389007 | MAP1B | 4131 | 0.06 | trans | ||
rs16944815 | chr13 | 91474365 | MAP1B | 4131 | 0.05 | trans | ||
snp_a-2171858 | 0 | MAP1B | 4131 | 0.05 | trans | |||
rs11842059 | chr13 | 91553390 | MAP1B | 4131 | 0.01 | trans | ||
rs17117421 | chr14 | 47008315 | MAP1B | 4131 | 0.17 | trans | ||
rs17127700 | chr14 | 55115256 | MAP1B | 4131 | 0.02 | trans | ||
snp_a-1912511 | 0 | MAP1B | 4131 | 8.696E-4 | trans | |||
rs7224708 | chr17 | 75782838 | MAP1B | 4131 | 0.01 | trans | ||
rs6096615 | chr20 | 50472392 | MAP1B | 4131 | 4.318E-4 | trans | ||
rs16999646 | chr21 | 25544091 | MAP1B | 4131 | 0.05 | trans | ||
rs455633 | chr21 | 28170785 | MAP1B | 4131 | 0.14 | trans | ||
rs464273 | chr21 | 28171591 | MAP1B | 4131 | 0.14 | trans | ||
rs229080 | chr21 | 28192989 | MAP1B | 4131 | 0.07 | trans | ||
rs2837968 | chr21 | 42586603 | MAP1B | 4131 | 0.15 | trans | ||
rs7887792 | chrX | 20508216 | MAP1B | 4131 | 0.01 | trans | ||
rs7061383 | chrX | 32937380 | MAP1B | 4131 | 7.338E-4 | trans | ||
rs17174152 | chrX | 70403143 | MAP1B | 4131 | 0.01 | trans | ||
rs16980072 | chrX | 84311360 | MAP1B | 4131 | 8.182E-4 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005515 | protein binding | IPI | 12147674 | |
GO:0005198 | structural molecule activity | NAS | 1881920 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0016358 | dendrite development | IEA | neurite, dendrite (GO term level: 11) | - |
GO:0001578 | microtubule bundle formation | IEA | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005829 | cytosol | IEA | - | |
GO:0005874 | microtubule | IEA | - | |
GO:0005875 | microtubule associated complex | TAS | 1881920 |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
ANP32A | C15orf1 | I1PP2A | LANP | MAPM | MGC119787 | MGC150373 | PHAP1 | PHAPI | PP32 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | - | HPRD,BioGRID | 12807913 |
DYNLL1 | DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1 | dynein, light chain, LC8-type 1 | - | HPRD | 14760703 |
FMR1 | FMRP | FRAXA | MGC87458 | POF | POF1 | fragile X mental retardation 1 | FMR1 (FMRP) interacts with MAP1B mRNA. This interaction was modeled on a demonstrated interaction between FMR1 from an unspecified species and human MAP1B mRNA. | BIND | 15381419 |
GABRR1 | MGC163216 | gamma-aminobutyric acid (GABA) receptor, rho 1 | - | HPRD | 9892354 |11102469 |
GABRR2 | - | gamma-aminobutyric acid (GABA) receptor, rho 2 | - | HPRD | 11102469 |
GAN | FLJ38059 | GAN1 | KLHL16 | gigaxonin | - | HPRD,BioGRID | 12147674 |
MAG | GMA | S-MAG | SIGLEC-4A | SIGLEC4A | myelin associated glycoprotein | - | HPRD,BioGRID | 11733546 |
MAP1A | FLJ77111 | MAP1L | MTAP1A | microtubule-associated protein 1A | - | HPRD,BioGRID | 2470876 |11002287 |
MAPK8 | JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1 | mitogen-activated protein kinase 8 | - | HPRD | 12689591 |
RASSF1 | 123F2 | NORE2A | RASSF1A | RDA32 | REH3P21 | Ras association (RalGDS/AF-6) domain family member 1 | Affinity Capture-Western Two-hybrid | BioGRID | 15205320 |
SNCA | MGC110988 | NACP | PARK1 | PARK4 | PD1 | synuclein, alpha (non A4 component of amyloid precursor) | - | HPRD,BioGRID | 10764738 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
ST DIFFERENTIATION PATHWAY IN PC12 CELLS | 45 | 35 | All SZGR 2.0 genes in this pathway |
PID REELIN PATHWAY | 29 | 29 | All SZGR 2.0 genes in this pathway |
PID NETRIN PATHWAY | 32 | 27 | All SZGR 2.0 genes in this pathway |
PID LIS1 PATHWAY | 28 | 22 | All SZGR 2.0 genes in this pathway |
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP | 285 | 181 | All SZGR 2.0 genes in this pathway |
LIU PROSTATE CANCER DN | 481 | 290 | All SZGR 2.0 genes in this pathway |
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP | 351 | 230 | All SZGR 2.0 genes in this pathway |
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN | 175 | 82 | All SZGR 2.0 genes in this pathway |
ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | All SZGR 2.0 genes in this pathway |
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN | 460 | 312 | All SZGR 2.0 genes in this pathway |
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL DN | 50 | 36 | All SZGR 2.0 genes in this pathway |
HORIUCHI WTAP TARGETS DN | 310 | 188 | All SZGR 2.0 genes in this pathway |
BASAKI YBX1 TARGETS UP | 290 | 177 | All SZGR 2.0 genes in this pathway |
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE UP | 79 | 50 | All SZGR 2.0 genes in this pathway |
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE DN | 43 | 29 | All SZGR 2.0 genes in this pathway |
PACHER TARGETS OF IGF1 AND IGF2 UP | 35 | 27 | All SZGR 2.0 genes in this pathway |
COLDREN GEFITINIB RESISTANCE UP | 85 | 57 | All SZGR 2.0 genes in this pathway |
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN | 234 | 147 | All SZGR 2.0 genes in this pathway |
CONCANNON APOPTOSIS BY EPOXOMICIN UP | 239 | 157 | All SZGR 2.0 genes in this pathway |
TANG SENESCENCE TP53 TARGETS DN | 57 | 33 | All SZGR 2.0 genes in this pathway |
PATIL LIVER CANCER | 747 | 453 | All SZGR 2.0 genes in this pathway |
DACOSTA UV RESPONSE VIA ERCC3 DN | 855 | 609 | All SZGR 2.0 genes in this pathway |
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN | 483 | 336 | All SZGR 2.0 genes in this pathway |
MARTORIATI MDM4 TARGETS FETAL LIVER DN | 514 | 319 | All SZGR 2.0 genes in this pathway |
MOHANKUMAR TLX1 TARGETS DN | 193 | 112 | All SZGR 2.0 genes in this pathway |
NUYTTEN EZH2 TARGETS UP | 1037 | 673 | All SZGR 2.0 genes in this pathway |
LIAO METASTASIS | 539 | 324 | All SZGR 2.0 genes in this pathway |
KOYAMA SEMA3B TARGETS UP | 292 | 168 | All SZGR 2.0 genes in this pathway |
WU CELL MIGRATION | 184 | 114 | All SZGR 2.0 genes in this pathway |
ONDER CDH1 TARGETS 2 UP | 256 | 159 | All SZGR 2.0 genes in this pathway |
ONDER CDH1 SIGNALING VIA CTNNB1 | 83 | 58 | All SZGR 2.0 genes in this pathway |
CERVERA SDHB TARGETS 1 UP | 118 | 66 | All SZGR 2.0 genes in this pathway |
BASSO B LYMPHOCYTE NETWORK | 143 | 96 | All SZGR 2.0 genes in this pathway |
SHIPP DLBCL CURED VS FATAL UP | 39 | 22 | All SZGR 2.0 genes in this pathway |
CHESLER BRAIN HIGHEST GENETIC VARIANCE | 37 | 21 | All SZGR 2.0 genes in this pathway |
DER IFN BETA RESPONSE UP | 102 | 67 | All SZGR 2.0 genes in this pathway |
BROCKE APOPTOSIS REVERSED BY IL6 | 144 | 98 | All SZGR 2.0 genes in this pathway |
ZHAN MULTIPLE MYELOMA CD1 VS CD2 UP | 66 | 47 | All SZGR 2.0 genes in this pathway |
TAVOR CEBPA TARGETS DN | 30 | 21 | All SZGR 2.0 genes in this pathway |
LU AGING BRAIN DN | 153 | 120 | All SZGR 2.0 genes in this pathway |
HENDRICKS SMARCA4 TARGETS UP | 56 | 35 | All SZGR 2.0 genes in this pathway |
KAAB HEART ATRIUM VS VENTRICLE UP | 249 | 170 | All SZGR 2.0 genes in this pathway |
RAMASWAMY METASTASIS DN | 61 | 47 | All SZGR 2.0 genes in this pathway |
LINDVALL IMMORTALIZED BY TERT DN | 80 | 56 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
YAMAZAKI TCEB3 TARGETS DN | 215 | 132 | All SZGR 2.0 genes in this pathway |
GENTILE UV RESPONSE CLUSTER D2 | 41 | 30 | All SZGR 2.0 genes in this pathway |
GENTILE UV HIGH DOSE DN | 312 | 203 | All SZGR 2.0 genes in this pathway |
CHENG RESPONSE TO NICKEL ACETATE | 45 | 29 | All SZGR 2.0 genes in this pathway |
WANG SMARCE1 TARGETS UP | 280 | 183 | All SZGR 2.0 genes in this pathway |
LEIN LOCALIZED TO PROXIMAL DENDRITES | 37 | 26 | All SZGR 2.0 genes in this pathway |
STEIN ESRRA TARGETS UP | 388 | 234 | All SZGR 2.0 genes in this pathway |
HELLER SILENCED BY METHYLATION DN | 105 | 67 | All SZGR 2.0 genes in this pathway |
MARTINEZ RB1 TARGETS UP | 673 | 430 | All SZGR 2.0 genes in this pathway |
MARTINEZ TP53 TARGETS UP | 602 | 364 | All SZGR 2.0 genes in this pathway |
MARTINEZ RB1 AND TP53 TARGETS UP | 601 | 369 | All SZGR 2.0 genes in this pathway |
SMID BREAST CANCER LUMINAL B DN | 564 | 326 | All SZGR 2.0 genes in this pathway |
YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
HINATA NFKB TARGETS FIBROBLAST UP | 84 | 60 | All SZGR 2.0 genes in this pathway |
STEIN ESRRA TARGETS | 535 | 325 | All SZGR 2.0 genes in this pathway |
HOSHIDA LIVER CANCER SUBCLASS S1 | 237 | 159 | All SZGR 2.0 genes in this pathway |
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR DN | 36 | 19 | All SZGR 2.0 genes in this pathway |
CHICAS RB1 TARGETS CONFLUENT | 567 | 365 | All SZGR 2.0 genes in this pathway |
CARD MIR302A TARGETS | 77 | 62 | All SZGR 2.0 genes in this pathway |
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP | 121 | 70 | All SZGR 2.0 genes in this pathway |
WIEDERSCHAIN TARGETS OF BMI1 AND PCGF2 | 57 | 39 | All SZGR 2.0 genes in this pathway |
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |
PEDERSEN METASTASIS BY ERBB2 ISOFORM 1 | 46 | 33 | All SZGR 2.0 genes in this pathway |
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN | 106 | 77 | All SZGR 2.0 genes in this pathway |
ALFANO MYC TARGETS | 239 | 156 | All SZGR 2.0 genes in this pathway |
RAO BOUND BY SALL4 | 227 | 149 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-124.1 | 937 | 943 | m8 | hsa-miR-124a | UUAAGGCACGCGGUGAAUGCCA |
miR-124/506 | 937 | 943 | 1A | hsa-miR-506 | UAAGGCACCCUUCUGAGUAGA |
hsa-miR-124brain | UAAGGCACGCGGUGAAUGCC | ||||
miR-143 | 240 | 246 | m8 | hsa-miR-143brain | UGAGAUGAAGCACUGUAGCUCA |
miR-181 | 954 | 961 | 1A,m8 | hsa-miR-181abrain | AACAUUCAACGCUGUCGGUGAGU |
hsa-miR-181bSZ | AACAUUCAUUGCUGUCGGUGGG | ||||
hsa-miR-181cbrain | AACAUUCAACCUGUCGGUGAGU | ||||
hsa-miR-181dbrain | AACAUUCAUUGUUGUCGGUGGGUU | ||||
miR-186 | 1181 | 1187 | 1A | hsa-miR-186 | CAAAGAAUUCUCCUUUUGGGCUU |
miR-223 | 282 | 288 | m8 | hsa-miR-223 | UGUCAGUUUGUCAAAUACCCC |
miR-224 | 948 | 954 | m8 | hsa-miR-224 | CAAGUCACUAGUGGUUCCGUUUA |
miR-26 | 951 | 957 | 1A | hsa-miR-26abrain | UUCAAGUAAUCCAGGAUAGGC |
hsa-miR-26bSZ | UUCAAGUAAUUCAGGAUAGGUU | ||||
miR-493-5p | 957 | 964 | 1A,m8 | hsa-miR-493-5p | UUGUACAUGGUAGGCUUUCAUU |
miR-9 | 902 | 908 | m8 | hsa-miR-9SZ | UCUUUGGUUAUCUAGCUGUAUGA |
miR-93.hd/291-3p/294/295/302/372/373/520 | 976 | 982 | 1A | hsa-miR-93brain | AAAGUGCUGUUCGUGCAGGUAG |
hsa-miR-302a | UAAGUGCUUCCAUGUUUUGGUGA | ||||
hsa-miR-302b | UAAGUGCUUCCAUGUUUUAGUAG | ||||
hsa-miR-302c | UAAGUGCUUCCAUGUUUCAGUGG | ||||
hsa-miR-302d | UAAGUGCUUCCAUGUUUGAGUGU | ||||
hsa-miR-372 | AAAGUGCUGCGACAUUUGAGCGU | ||||
hsa-miR-373 | GAAGUGCUUCGAUUUUGGGGUGU | ||||
hsa-miR-520e | AAAGUGCUUCCUUUUUGAGGG | ||||
hsa-miR-520a | AAAGUGCUUCCCUUUGGACUGU | ||||
hsa-miR-520b | AAAGUGCUUCCUUUUAGAGGG | ||||
hsa-miR-520c | AAAGUGCUUCCUUUUAGAGGGUU | ||||
hsa-miR-520d | AAAGUGCUUCUCUUUGGUGGGUU |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.