SZGR2

Summary ?

GeneID	4131
Symbol	MAP1B
Synonyms	FUTSCH\|MAP5\|PPP1R102
Description	microtubule associated protein 1B
Reference	MIM:157129\|HGNC:HGNC:6836\|Ensembl:ENSG00000131711\|HPRD:01139\|Vega:OTTHUMG00000100952
Gene type	protein-coding
Map location	5q13
Pascal p-value	0.558
Sherlock p-value	0.504
Fetal beta	0.952
eGene	Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Myers' cis & trans
Support	STRUCTURAL PLASTICITY G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_clathrin G2Cdb.human_mGluR5 G2Cdb.human_Synaptosome CompositeSet Darnell FMRP targets Ascano FMRP targets Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs16899493	chr5	71836880	MAP1B	4131	0.04	cis
snp_a-2040925		0	MAP1B	4131	0.03	trans
rs11122162	chr1	231097041	MAP1B	4131	0.06	trans
rs16843810	chr1	234827318	MAP1B	4131	0.05	trans
rs11127467	chr2	12993	MAP1B	4131	0	trans
rs17040095	chr2	65926994	MAP1B	4131	0.17	trans
rs9813119	chr3	45230566	MAP1B	4131	0.02	trans
rs192095	chr3	111821862	MAP1B	4131	0.13	trans
rs16830299	chr3	159090973	MAP1B	4131	0.16	trans
rs4698397	chr4	15534712	MAP1B	4131	2.682E-5	trans
rs16992737	chr4	36849942	MAP1B	4131	0.02	trans
rs17270544	chr4	182529568	MAP1B	4131	4.888E-4	trans
rs17211786	chr4	182548238	MAP1B	4131	2.69E-4	trans
rs2434733	chr5	154431911	MAP1B	4131	0.01	trans
rs1494142	chr6	125778157	MAP1B	4131	0.15	trans
rs6937122	chr6	143694842	MAP1B	4131	0.03	trans
rs7760371	chr6	143712251	MAP1B	4131	0.02	trans
rs17081113	chr6	151637449	MAP1B	4131	0.08	trans
rs12112911	chr7	26297444	MAP1B	4131	0.1	trans
rs868269	chr7	76007808	MAP1B	4131	0.12	trans
rs7817138	chr8	111140526	MAP1B	4131	0.04	trans
rs10505136	chr8	111141220	MAP1B	4131	0.04	trans
rs4743895	chr9	95905749	MAP1B	4131	0.19	trans
rs16919567	chr9	103624176	MAP1B	4131	0.04	trans
rs7864609	chr9	117884215	MAP1B	4131	0	trans
rs10818070	chr9	120456494	MAP1B	4131	0.17	trans
rs7864330	chr9	120469549	MAP1B	4131	0.08	trans
rs7087570	chr10	19940964	MAP1B	4131	0.03	trans
rs7910314	chr10	56004456	MAP1B	4131	0.03	trans
rs1236903	chr10	71198993	MAP1B	4131	0.16	trans
rs3740184	chr10	127356543	MAP1B	4131	0.16	trans
rs1436802	chr10	128204332	MAP1B	4131	0.12	trans
rs1036454	chr10	128211573	MAP1B	4131	0.11	trans
rs766095	chr12	1498432	MAP1B	4131	0.01	trans
rs7135241	chr12	95163565	MAP1B	4131	0	trans
rs11110940	chr12	102054842	MAP1B	4131	0.02	trans
rs11110942	chr12	102055094	MAP1B	4131	0.09	trans
rs10860768	chr12	102069497	MAP1B	4131	0	trans
rs12230291	chr12	102100263	MAP1B	4131	3.336E-4	trans
snp_a-4249110		0	MAP1B	4131	3.336E-4	trans
rs11111009	chr12	102160626	MAP1B	4131	3.336E-4	trans
rs10860798	chr12	102251472	MAP1B	4131	0.12	trans
rs17032130	chr12	102331171	MAP1B	4131	3.336E-4	trans
rs17032134	chr12	102331946	MAP1B	4131	3.336E-4	trans
rs11111120	chr12	102389007	MAP1B	4131	0.06	trans
rs16944815	chr13	91474365	MAP1B	4131	0.05	trans
snp_a-2171858		0	MAP1B	4131	0.05	trans
rs11842059	chr13	91553390	MAP1B	4131	0.01	trans
rs17117421	chr14	47008315	MAP1B	4131	0.17	trans
rs17127700	chr14	55115256	MAP1B	4131	0.02	trans
snp_a-1912511		0	MAP1B	4131	8.696E-4	trans
rs7224708	chr17	75782838	MAP1B	4131	0.01	trans
rs6096615	chr20	50472392	MAP1B	4131	4.318E-4	trans
rs16999646	chr21	25544091	MAP1B	4131	0.05	trans
rs455633	chr21	28170785	MAP1B	4131	0.14	trans
rs464273	chr21	28171591	MAP1B	4131	0.14	trans
rs229080	chr21	28192989	MAP1B	4131	0.07	trans
rs2837968	chr21	42586603	MAP1B	4131	0.15	trans
rs7887792	chrX	20508216	MAP1B	4131	0.01	trans
rs7061383	chrX	32937380	MAP1B	4131	7.338E-4	trans
rs17174152	chrX	70403143	MAP1B	4131	0.01	trans
rs16980072	chrX	84311360	MAP1B	4131	8.182E-4	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		12147674
GO:0005198	structural molecule activity	NAS		1881920
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0016358	dendrite development	IEA	neurite, dendrite (GO term level: 11)	-
GO:0001578	microtubule bundle formation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	IEA		-
GO:0005874	microtubule	IEA		-
GO:0005875	microtubule associated complex	TAS		1881920

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ANP32A	C15orf1 \| I1PP2A \| LANP \| MAPM \| MGC119787 \| MGC150373 \| PHAP1 \| PHAPI \| PP32	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	-	HPRD,BioGRID	12807913
DYNLL1	DLC1 \| DLC8 \| DNCL1 \| DNCLC1 \| LC8 \| LC8a \| MGC126137 \| MGC126138 \| PIN \| hdlc1	dynein, light chain, LC8-type 1	-	HPRD	14760703
FMR1	FMRP \| FRAXA \| MGC87458 \| POF \| POF1	fragile X mental retardation 1	FMR1 (FMRP) interacts with MAP1B mRNA. This interaction was modeled on a demonstrated interaction between FMR1 from an unspecified species and human MAP1B mRNA.	BIND	15381419
GABRR1	MGC163216	gamma-aminobutyric acid (GABA) receptor, rho 1	-	HPRD	9892354 \|11102469
GABRR2	-	gamma-aminobutyric acid (GABA) receptor, rho 2	-	HPRD	11102469
GAN	FLJ38059 \| GAN1 \| KLHL16	gigaxonin	-	HPRD,BioGRID	12147674
MAG	GMA \| S-MAG \| SIGLEC-4A \| SIGLEC4A	myelin associated glycoprotein	-	HPRD,BioGRID	11733546
MAP1A	FLJ77111 \| MAP1L \| MTAP1A	microtubule-associated protein 1A	-	HPRD,BioGRID	2470876 \|11002287
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	-	HPRD	12689591
RASSF1	123F2 \| NORE2A \| RASSF1A \| RDA32 \| REH3P21	Ras association (RalGDS/AF-6) domain family member 1	Affinity Capture-Western Two-hybrid	BioGRID	15205320
SNCA	MGC110988 \| NACP \| PARK1 \| PARK4 \| PD1	synuclein, alpha (non A4 component of amyloid precursor)	-	HPRD,BioGRID	10764738

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
ST DIFFERENTIATION PATHWAY IN PC12 CELLS	45	35	All SZGR 2.0 genes in this pathway
PID REELIN PATHWAY	29	29	All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY	32	27	All SZGR 2.0 genes in this pathway
PID LIS1 PATHWAY	28	22	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP	285	181	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP	351	230	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN	175	82	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP	485	293	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL DN	50	36	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN	310	188	All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP	290	177	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE UP	79	50	All SZGR 2.0 genes in this pathway
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE DN	43	29	All SZGR 2.0 genes in this pathway
PACHER TARGETS OF IGF1 AND IGF2 UP	35	27	All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE UP	85	57	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN	234	147	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP	239	157	All SZGR 2.0 genes in this pathway
TANG SENESCENCE TP53 TARGETS DN	57	33	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS DN	193	112	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
LIAO METASTASIS	539	324	All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP	292	168	All SZGR 2.0 genes in this pathway
WU CELL MIGRATION	184	114	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP	256	159	All SZGR 2.0 genes in this pathway
ONDER CDH1 SIGNALING VIA CTNNB1	83	58	All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 UP	118	66	All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK	143	96	All SZGR 2.0 genes in this pathway
SHIPP DLBCL CURED VS FATAL UP	39	22	All SZGR 2.0 genes in this pathway
CHESLER BRAIN HIGHEST GENETIC VARIANCE	37	21	All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP	102	67	All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6	144	98	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 VS CD2 UP	66	47	All SZGR 2.0 genes in this pathway
TAVOR CEBPA TARGETS DN	30	21	All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN	153	120	All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP	56	35	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP	249	170	All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS DN	61	47	All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT DN	80	56	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN	215	132	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D2	41	30	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
CHENG RESPONSE TO NICKEL ACETATE	45	29	All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP	280	183	All SZGR 2.0 genes in this pathway
LEIN LOCALIZED TO PROXIMAL DENDRITES	37	26	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP	388	234	All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN	105	67	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN	564	326	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP	84	60	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS	535	325	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1	237	159	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR DN	36	19	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT	567	365	All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS	77	62	All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP	121	70	All SZGR 2.0 genes in this pathway
WIEDERSCHAIN TARGETS OF BMI1 AND PCGF2	57	39	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 1	46	33	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN	106	77	All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS	239	156	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4	227	149	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	937	943	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	937	943	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	937	943	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-143	240	246	m8	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-181	954	961	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-186	1181	1187	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-223	282	288	m8	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-224	948	954	m8	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-26	951	957	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	951	957	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-493-5p	957	964	1A,m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-9	902	908	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-93.hd/291-3p/294/295/302/372/373/520	976	982	1A	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MAP1B