Gene Page: NDN

Summary
GeneID  4692
Symbol  NDN
Synonyms  HsT16328|PWCR
Description  necdin homolog (mouse)
See related  HGNC:7675|MIM:602117|Ensembl:ENSG00000182636|HPRD:03667|
Locus tag  -
Gene type  protein-coding
Map location  15q11.2-q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NHP20.870.85
MRPS240.840.79
C12orf100.830.80
AC174470.10.830.79
GADD45GIP10.830.80
TOMM50.830.81
RABAC10.820.78
POP70.820.79
EXOSC40.820.81
CCDC560.820.79
Top 10 negatively co-expressed genes
AF347015.26-0.61-0.61
AF347015.2-0.58-0.57
AF347015.15-0.57-0.58
AF347015.33-0.57-0.58
MT-CYB-0.56-0.57
AF347015.8-0.56-0.56
MT-CO2-0.52-0.51
AF347015.18-0.51-0.54
AF347015.9-0.51-0.56
FAM38A-0.51-0.52
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0005515protein bindingIPI17353931 
GO:0043015gamma-tubulin bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentIEABrain (GO term level: 6)-
GO:0007413axonal fasciculationIEAneuron, axon (GO term level: 13)-
GO:0001764neuron migrationIEAneuron (GO term level: 8)-
GO:0048676axon extension involved in developmentIEAaxon (GO term level: 14)-
GO:0048666neuron developmentIEAneuron (GO term level: 9)-
GO:0008347glial cell migrationIEAneuron, Glial (GO term level: 8)-
GO:0001558regulation of cell growthIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0008285negative regulation of cell proliferationTAS9630521 
GO:0007585respiratory gaseous exchangeIEA-
GO:0048011nerve growth factor receptor signaling pathwayIEA-
GO:0019233sensory perception of painIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIEA-
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0043204perikaryonIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARSECDPX | CDPX1 | CDPXR | MGC163310arylsulfatase E (chondrodysplasia punctata 1)Two-hybridBioGRID16169070 
AUP1-ancient ubiquitous protein 1Affinity Capture-MSBioGRID17353931 
DHCR7SLOS7-dehydrocholesterol reductaseAffinity Capture-MSBioGRID17353931 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1-HPRD,BioGRID9422723 |14593116 
E2F4E2F-4E2F transcription factor 4, p107/p130-binding-HPRD12198120 
HNRNPUHNRPU | SAF-A | U21.1heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)-HPRD,BioGRID11813259 
IL1AIL-1A | IL1 | IL1-ALPHA | IL1F1interleukin 1, alpha-HPRD,BioGRID12913118 
LASS2CerS2 | FLJ10243 | L3 | MGC987 | SP260 | TMSG1LAG1 homolog, ceramide synthase 2Affinity Capture-MSBioGRID17353931 
NDNHsT16328 | PWCRnecdin homolog (mouse)-HPRD12414813 
Two-hybridBioGRID10915798 
NGFRCD271 | Gp80-LNGFR | TNFRSF16 | p75(NTR) | p75NTRnerve growth factor receptor (TNFR superfamily, member 16)-HPRD,BioGRID12414813 |12716928 
|14593116 
NUBP1MGC117406 | MGC130052 | MGC130053 | NBP | NBP1nucleotide binding protein 1 (MinD homolog, E. coli)-HPRD,BioGRID10915798 
NUCB2NEFAnucleobindin 2-HPRD,BioGRID10915798 
PJA1RNF70praja 1-HPRD,BioGRID11959851 
RPS11-ribosomal protein S11Affinity Capture-MSBioGRID17353931 
SEC61A1HSEC61 | SEC61 | SEC61ASec61 alpha 1 subunit (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
SRPRBAPMCF1signal recognition particle receptor, B subunitAffinity Capture-MSBioGRID17353931 
TMEM331600019D15Rik | FLJ10525 | SHINC3transmembrane protein 33Affinity Capture-MSBioGRID17353931 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID10347180 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_DN 8659All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_UP 316190All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN 199124All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN 196131All SZGR genes in this pathway
WONG_ENDMETRIUM_CANCER_DN 8253All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_APOBEC2 2719All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_12HR 4335All SZGR genes in this pathway
JOHANSSON_BRAIN_CANCER_EARLY_VS_LATE_DN 4535All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN 176104All SZGR genes in this pathway
FRIDMAN_SENESCENCE_UP 7760All SZGR genes in this pathway
FRIDMAN_IMMORTALIZATION_DN 3424All SZGR genes in this pathway
KANNAN_TP53_TARGETS_UP 5840All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_UP 5735All SZGR genes in this pathway
POMEROY_MEDULLOBLASTOMA_PROGNOSIS_UP 4730All SZGR genes in this pathway
GUO_HEX_TARGETS_UP 8154All SZGR genes in this pathway
AFFAR_YY1_TARGETS_DN 234137All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_MUSCLE_UP 4333All SZGR genes in this pathway
LEE_AGING_MUSCLE_DN 4629All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
TSENG_IRS1_TARGETS_UP 11371All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
KRASNOSELSKAYA_ILF3_TARGETS_DN 4638All SZGR genes in this pathway
TSENG_ADIPOGENIC_POTENTIAL_UP 3019All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_DN 10868All SZGR genes in this pathway
SCHRAETS_MLL_TARGETS_UP 3521All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
LEE_INTRATHYMIC_T_PROGENITOR 2114All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP 207143All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_UP 166105All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_DN 7447All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
BRIDEAU_IMPRINTED_GENES 6347All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-200bc/4299298m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-21790961Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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