Gene Page: NME2
Summary ?
| GeneID | 4831 |
| Symbol | NME2 |
| Synonyms | NDKB|NDPK-B|NDPKB|NM23-H2|NM23B|PUF |
| Description | NME/NM23 nucleoside diphosphate kinase 2 |
| Reference | MIM:156491|HGNC:HGNC:7850|Ensembl:ENSG00000011052|Ensembl:ENSG00000243678|HPRD:01132|Vega:OTTHUMG00000154062 |
| Gene type | protein-coding |
| Map location | 17q21.3 |
| Pascal p-value | 0.031 |
| Sherlock p-value | 0.968 |
| eGene | Myers' cis & trans |
| Support | CELL METABOLISM G2Cdb.human_clathrin G2Cdb.human_Synaptosome G2Cdb.humanPSD G2Cdb.humanPSP |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0283 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs9966136 | chr18 | 74881659 | NME2 | 4831 | 0.03 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RAP1GAP | 0.81 | 0.87 |
| SLC35F3 | 0.80 | 0.83 |
| RASGEF1A | 0.77 | 0.85 |
| SLC12A8 | 0.77 | 0.81 |
| CPNE5 | 0.77 | 0.75 |
| PDE2A | 0.77 | 0.82 |
| DRP2 | 0.76 | 0.80 |
| STIM1 | 0.76 | 0.82 |
| ABAT | 0.76 | 0.76 |
| NGEF | 0.76 | 0.79 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SNRPG | -0.41 | -0.53 |
| RPL38 | -0.41 | -0.54 |
| RPL34 | -0.41 | -0.49 |
| RPL31 | -0.40 | -0.43 |
| RPS20 | -0.40 | -0.50 |
| RPL35A | -0.40 | -0.48 |
| RPL27 | -0.40 | -0.42 |
| RPL24 | -0.40 | -0.43 |
| HEBP2 | -0.39 | -0.54 |
| RPL13AP22 | -0.39 | -0.56 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0000287 | magnesium ion binding | IEA | - | |
| GO:0003700 | transcription factor activity | TAS | 8392752 | |
| GO:0005515 | protein binding | IPI | 17353931 | |
| GO:0005524 | ATP binding | IEA | - | |
| GO:0005524 | ATP binding | NAS | - | |
| GO:0004550 | nucleoside diphosphate kinase activity | IEA | - | |
| GO:0004550 | nucleoside diphosphate kinase activity | TAS | - | |
| GO:0016740 | transferase activity | IEA | - | |
| GO:0016301 | kinase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0009117 | nucleotide metabolic process | IEA | - | |
| GO:0006355 | regulation of transcription, DNA-dependent | TAS | 8392752 | |
| GO:0007155 | cell adhesion | TAS | 11919189 | |
| GO:0006350 | transcription | IEA | - | |
| GO:0006241 | CTP biosynthetic process | IEA | - | |
| GO:0006228 | UTP biosynthetic process | IEA | - | |
| GO:0006183 | GTP biosynthetic process | IEA | - | |
| GO:0008285 | negative regulation of cell proliferation | TAS | - | |
| GO:0009142 | nucleoside triphosphate biosynthetic process | NAS | - | |
| GO:0043066 | negative regulation of apoptosis | IMP | 16862176 | |
| GO:0045618 | positive regulation of keratinocyte differentiation | IMP | 16862176 | |
| GO:0050679 | positive regulation of epithelial cell proliferation | IMP | 16862176 | |
| GO:0045786 | negative regulation of cell cycle | IEA | - | |
| GO:0045682 | regulation of epidermis development | IMP | 16862176 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0001726 | ruffle | IDA | 11919189 | |
| GO:0005634 | nucleus | NAS | - | |
| GO:0005737 | cytoplasm | IEA | - | |
| GO:0030027 | lamellipodium | IDA | 11919189 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ACLY | ACL | ATPCL | CLATP | ATP citrate lyase | Affinity Capture-MS | BioGRID | 17353931 |
| AKAP13 | AKAP-Lbc | BRX | FLJ11952 | FLJ43341 | HA-3 | Ht31 | LBC | PROTO-LB | PROTO-LBC | c-lbc | A kinase (PRKA) anchor protein 13 | Lbc interacts with nm23-H2. | BIND | 15249197 |
| ATIC | AICAR | AICARFT | FLJ93545 | IMPCHASE | PURH | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | Affinity Capture-MS | BioGRID | 17353931 |
| DNM1 | DNM | dynamin 1 | - | HPRD | 11872741 |
| DYNC1H1 | DHC1 | DHC1a | DKFZp686P2245 | DNCH1 | DNCL | DNECL | DYHC | Dnchc1 | HL-3 | KIAA0325 | p22 | dynein, cytoplasmic 1, heavy chain 1 | Affinity Capture-MS | BioGRID | 17353931 |
| EPPK1 | EPIPL | EPIPL1 | epiplakin 1 | Affinity Capture-MS | BioGRID | 17353931 |
| HIST1H2BC | H2B.1 | H2B/l | H2BFL | MGC104246 | dJ221C16.3 | histone cluster 1, H2bc | Affinity Capture-MS | BioGRID | 17353931 |
| HTR1B | 5-HT1B | 5-HT1DB | HTR1D2 | HTR1DB | S12 | 5-hydroxytryptamine (serotonin) receptor 1B | Affinity Capture-MS | BioGRID | 17353931 |
| ITGB1BP1 | DKFZp686K08158 | ICAP-1A | ICAP-1B | ICAP-1alpha | ICAP1 | ICAP1A | ICAP1B | integrin beta 1 binding protein 1 | ICAP-1-alpha interacts with nm23-H2. | BIND | 11919189 |
| KIF5B | KINH | KNS | KNS1 | UKHC | kinesin family member 5B | Affinity Capture-MS | BioGRID | 17353931 |
| LYZ | LZM | lysozyme (renal amyloidosis) | Affinity Capture-MS | BioGRID | 17353931 |
| MOBKL3 | 2C4D | CGI-95 | MGC12264 | MOB1 | MOB3 | PREI3 | MOB1, Mps One Binder kinase activator-like 3 (yeast) | - | HPRD | 11872741 |
| NME2 | MGC111212 | NDPK-B | NDPKB | NM23-H2 | NM23B | puf | non-metastatic cells 2, protein (NM23B) expressed in | - | HPRD,BioGRID | 7658474 |
| NME3 | DR-nm23 | KIAA0516 | NDPK-C | NDPKC | NM23-H3 | c371H6.2 | non-metastatic cells 3, protein expressed in | - | HPRD,BioGRID | 11042679 |
| PDIA6 | ERP5 | P5 | TXNDC7 | protein disulfide isomerase family A, member 6 | Affinity Capture-MS | BioGRID | 17353931 |
| POLR2H | RPABC3 | RPB17 | RPB8 | hsRPB8 | polymerase (RNA) II (DNA directed) polypeptide H | Affinity Capture-MS | BioGRID | 17353931 |
| PPP1R7 | SDS22 | protein phosphatase 1, regulatory (inhibitor) subunit 7 | Affinity Capture-MS | BioGRID | 17353931 |
| PPP1R8 | ARD-1 | ARD1 | NIPP-1 | NIPP1 | PRO2047 | protein phosphatase 1, regulatory (inhibitor) subunit 8 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMA2 | HC3 | MU | PMSA2 | PSC2 | proteasome (prosome, macropain) subunit, alpha type, 2 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMA7 | C6 | HSPC | MGC3755 | RC6-1 | XAPC7 | proteasome (prosome, macropain) subunit, alpha type, 7 | Affinity Capture-MS | BioGRID | 17353931 |
| RORA | DKFZp686M2414 | MGC119326 | MGC119329 | NR1F1 | ROR1 | ROR2 | ROR3 | RZR-ALPHA | RZRA | RAR-related orphan receptor A | - | HPRD | 8858107 |
| RPL38 | - | ribosomal protein L38 | Affinity Capture-MS | BioGRID | 17353931 |
| RUVBL2 | CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49B | RuvB-like 2 (E. coli) | Affinity Capture-MS | BioGRID | 17353931 |
| STIP1 | HOP | IEF-SSP-3521 | P60 | STI1 | STI1L | stress-induced-phosphoprotein 1 | Affinity Capture-MS | BioGRID | 17353931 |
| TERF1 | FLJ41416 | PIN2 | TRBF1 | TRF | TRF1 | hTRF1-AS | t-TRF1 | telomeric repeat binding factor (NIMA-interacting) 1 | - | HPRD | 9480811 |
| TERF1 | FLJ41416 | PIN2 | TRBF1 | TRF | TRF1 | hTRF1-AS | t-TRF1 | telomeric repeat binding factor (NIMA-interacting) 1 | TRF1 interacts with nm23-H2. | BIND | 9480811 |
| VIM | FLJ36605 | vimentin | - | HPRD,BioGRID | 11082283 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PURINE METABOLISM | 159 | 96 | All SZGR 2.0 genes in this pathway |
| KEGG PYRIMIDINE METABOLISM | 98 | 53 | All SZGR 2.0 genes in this pathway |
| BIOCARTA NDKDYNAMIN PATHWAY | 21 | 15 | All SZGR 2.0 genes in this pathway |
| PID MYC ACTIV PATHWAY | 79 | 62 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF NUCLEOTIDES | 72 | 45 | All SZGR 2.0 genes in this pathway |
| REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | 19 | 10 | All SZGR 2.0 genes in this pathway |
| WANG ESOPHAGUS CANCER VS NORMAL UP | 121 | 72 | All SZGR 2.0 genes in this pathway |
| LI AMPLIFIED IN LUNG CANCER | 178 | 108 | All SZGR 2.0 genes in this pathway |
| KIM MYC AMPLIFICATION TARGETS UP | 201 | 127 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | All SZGR 2.0 genes in this pathway |
| FRIDMAN SENESCENCE UP | 77 | 60 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON | 335 | 181 | All SZGR 2.0 genes in this pathway |
| BHATTACHARYA EMBRYONIC STEM CELL | 89 | 60 | All SZGR 2.0 genes in this pathway |
| KAAB FAILED HEART ATRIUM DN | 141 | 99 | All SZGR 2.0 genes in this pathway |
| KAAB HEART ATRIUM VS VENTRICLE UP | 249 | 170 | All SZGR 2.0 genes in this pathway |
| MURAKAMI UV RESPONSE 6HR UP | 37 | 31 | All SZGR 2.0 genes in this pathway |
| ZHANG PROLIFERATING VS QUIESCENT | 51 | 41 | All SZGR 2.0 genes in this pathway |
| VERRECCHIA EARLY RESPONSE TO TGFB1 | 58 | 43 | All SZGR 2.0 genes in this pathway |
| WEIGEL OXIDATIVE STRESS BY HNE AND TBH | 60 | 42 | All SZGR 2.0 genes in this pathway |
| KAAB FAILED HEART VENTRICLE DN | 41 | 28 | All SZGR 2.0 genes in this pathway |
| VERRECCHIA RESPONSE TO TGFB1 C3 | 14 | 10 | All SZGR 2.0 genes in this pathway |
| HILLION HMGA1 TARGETS | 90 | 71 | All SZGR 2.0 genes in this pathway |
| ALONSO METASTASIS UP | 198 | 128 | All SZGR 2.0 genes in this pathway |
| HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP | 163 | 102 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
| IRITANI MAD1 TARGETS DN | 47 | 30 | All SZGR 2.0 genes in this pathway |
| DANG MYC TARGETS UP | 143 | 100 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| WONG EMBRYONIC STEM CELL CORE | 335 | 193 | All SZGR 2.0 genes in this pathway |
| MURAKAMI UV RESPONSE 1HR UP | 17 | 10 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS UP | 295 | 155 | All SZGR 2.0 genes in this pathway |
| SUBTIL PROGESTIN TARGETS | 36 | 25 | All SZGR 2.0 genes in this pathway |
| BILANGES RAPAMYCIN SENSITIVE VIA TSC1 AND TSC2 | 73 | 37 | All SZGR 2.0 genes in this pathway |