Gene Page: NME2

Summary
GeneID  4831
Symbol  NME2
Synonyms  MGC111212|NDPK-B|NDPKB|NM23-H2|NM23B|puf
Description  non-metastatic cells 2, protein (NM23B) expressed in
See related  HGNC:7850|MIM:156491|Ensembl:ENSG00000011052|HPRD:01132|
Locus tag  -
Gene type  protein-coding
Map location  17q21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0283 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RAP1GAP0.810.87
SLC35F30.800.83
RASGEF1A0.770.85
SLC12A80.770.81
CPNE50.770.75
PDE2A0.770.82
DRP20.760.80
STIM10.760.82
ABAT0.760.76
NGEF0.760.79
Top 10 negatively co-expressed genes
SNRPG-0.41-0.53
RPL38-0.41-0.54
RPL34-0.41-0.49
RPL31-0.40-0.43
RPS20-0.40-0.50
RPL35A-0.40-0.48
RPL27-0.40-0.42
RPL24-0.40-0.43
HEBP2-0.39-0.54
RPL13AP22-0.39-0.56
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0003700transcription factor activityTAS8392752 
GO:0005515protein bindingIPI17353931 
GO:0005524ATP bindingIEA-
GO:0005524ATP bindingNAS-
GO:0004550nucleoside diphosphate kinase activityIEA-
GO:0004550nucleoside diphosphate kinase activityTAS-
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0009117nucleotide metabolic processIEA-
GO:0006355regulation of transcription, DNA-dependentTAS8392752 
GO:0007155cell adhesionTAS11919189 
GO:0006350transcriptionIEA-
GO:0006241CTP biosynthetic processIEA-
GO:0006228UTP biosynthetic processIEA-
GO:0006183GTP biosynthetic processIEA-
GO:0008285negative regulation of cell proliferationTAS-
GO:0009142nucleoside triphosphate biosynthetic processNAS-
GO:0043066negative regulation of apoptosisIMP16862176 
GO:0045618positive regulation of keratinocyte differentiationIMP16862176 
GO:0050679positive regulation of epithelial cell proliferationIMP16862176 
GO:0045786negative regulation of cell cycleIEA-
GO:0045682regulation of epidermis developmentIMP16862176 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001726ruffleIDA11919189 
GO:0005634nucleusNAS-
GO:0005737cytoplasmIEA-
GO:0030027lamellipodiumIDA11919189 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACLYACL | ATPCL | CLATPATP citrate lyaseAffinity Capture-MSBioGRID17353931 
AKAP13AKAP-Lbc | BRX | FLJ11952 | FLJ43341 | HA-3 | Ht31 | LBC | PROTO-LB | PROTO-LBC | c-lbcA kinase (PRKA) anchor protein 13Lbc interacts with nm23-H2.BIND15249197 
ATICAICAR | AICARFT | FLJ93545 | IMPCHASE | PURH5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolaseAffinity Capture-MSBioGRID17353931 
DNM1DNMdynamin 1-HPRD11872741 
DYNC1H1DHC1 | DHC1a | DKFZp686P2245 | DNCH1 | DNCL | DNECL | DYHC | Dnchc1 | HL-3 | KIAA0325 | p22dynein, cytoplasmic 1, heavy chain 1Affinity Capture-MSBioGRID17353931 
EPPK1EPIPL | EPIPL1epiplakin 1Affinity Capture-MSBioGRID17353931 
HIST1H2BCH2B.1 | H2B/l | H2BFL | MGC104246 | dJ221C16.3histone cluster 1, H2bcAffinity Capture-MSBioGRID17353931 
HTR1B5-HT1B | 5-HT1DB | HTR1D2 | HTR1DB | S125-hydroxytryptamine (serotonin) receptor 1BAffinity Capture-MSBioGRID17353931 
ITGB1BP1DKFZp686K08158 | ICAP-1A | ICAP-1B | ICAP-1alpha | ICAP1 | ICAP1A | ICAP1Bintegrin beta 1 binding protein 1ICAP-1-alpha interacts with nm23-H2.BIND11919189 
KIF5BKINH | KNS | KNS1 | UKHCkinesin family member 5BAffinity Capture-MSBioGRID17353931 
LYZLZMlysozyme (renal amyloidosis)Affinity Capture-MSBioGRID17353931 
MOBKL32C4D | CGI-95 | MGC12264 | MOB1 | MOB3 | PREI3MOB1, Mps One Binder kinase activator-like 3 (yeast)-HPRD11872741 
NME2MGC111212 | NDPK-B | NDPKB | NM23-H2 | NM23B | pufnon-metastatic cells 2, protein (NM23B) expressed in-HPRD,BioGRID7658474 
NME3DR-nm23 | KIAA0516 | NDPK-C | NDPKC | NM23-H3 | c371H6.2non-metastatic cells 3, protein expressed in-HPRD,BioGRID11042679 
PDIA6ERP5 | P5 | TXNDC7protein disulfide isomerase family A, member 6Affinity Capture-MSBioGRID17353931 
POLR2HRPABC3 | RPB17 | RPB8 | hsRPB8polymerase (RNA) II (DNA directed) polypeptide HAffinity Capture-MSBioGRID17353931 
PPP1R7SDS22protein phosphatase 1, regulatory (inhibitor) subunit 7Affinity Capture-MSBioGRID17353931 
PPP1R8ARD-1 | ARD1 | NIPP-1 | NIPP1 | PRO2047protein phosphatase 1, regulatory (inhibitor) subunit 8Affinity Capture-MSBioGRID17353931 
PSMA2HC3 | MU | PMSA2 | PSC2proteasome (prosome, macropain) subunit, alpha type, 2Affinity Capture-MSBioGRID17353931 
PSMA7C6 | HSPC | MGC3755 | RC6-1 | XAPC7proteasome (prosome, macropain) subunit, alpha type, 7Affinity Capture-MSBioGRID17353931 
RORADKFZp686M2414 | MGC119326 | MGC119329 | NR1F1 | ROR1 | ROR2 | ROR3 | RZR-ALPHA | RZRARAR-related orphan receptor A-HPRD8858107 
RPL38-ribosomal protein L38Affinity Capture-MSBioGRID17353931 
RUVBL2CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49BRuvB-like 2 (E. coli)Affinity Capture-MSBioGRID17353931 
STIP1HOP | IEF-SSP-3521 | P60 | STI1 | STI1Lstress-induced-phosphoprotein 1Affinity Capture-MSBioGRID17353931 
TERF1FLJ41416 | PIN2 | TRBF1 | TRF | TRF1 | hTRF1-AS | t-TRF1telomeric repeat binding factor (NIMA-interacting) 1-HPRD9480811 
TRF1 interacts with nm23-H2.BIND9480811 
VIMFLJ36605vimentin-HPRD,BioGRID11082283 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PURINE_METABOLISM 15996All SZGR genes in this pathway
KEGG_PYRIMIDINE_METABOLISM 9853All SZGR genes in this pathway
BIOCARTA_NDKDYNAMIN_PATHWAY 2115All SZGR genes in this pathway
PID_MYC_ACTIV_PATHWAY 7962All SZGR genes in this pathway
REACTOME_METABOLISM_OF_NUCLEOTIDES 7245All SZGR genes in this pathway
REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES 1910All SZGR genes in this pathway
WANG_ESOPHAGUS_CANCER_VS_NORMAL_UP 12172All SZGR genes in this pathway
LI_AMPLIFIED_IN_LUNG_CANCER 178108All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_UP 201127All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
FRIDMAN_SENESCENCE_UP 7760All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN 517309All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON 335181All SZGR genes in this pathway
BHATTACHARYA_EMBRYONIC_STEM_CELL 8960All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_UP 3731All SZGR genes in this pathway
ZHANG_PROLIFERATING_VS_QUIESCENT 5141All SZGR genes in this pathway
VERRECCHIA_EARLY_RESPONSE_TO_TGFB1 5843All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_TBH 6042All SZGR genes in this pathway
KAAB_FAILED_HEART_VENTRICLE_DN 4128All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C3 1410All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
ALONSO_METASTASIS_UP 198128All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 163102All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
IRITANI_MAD1_TARGETS_DN 4730All SZGR genes in this pathway
DANG_MYC_TARGETS_UP 143100All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_1HR_UP 1710All SZGR genes in this pathway
LU_EZH2_TARGETS_UP 295155All SZGR genes in this pathway
SUBTIL_PROGESTIN_TARGETS 3625All SZGR genes in this pathway
BILANGES_RAPAMYCIN_SENSITIVE_VIA_TSC1_AND_TSC2 7337All SZGR genes in this pathway


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