SZGR2

Summary ?

GeneID	4928
Symbol	NUP98
Synonyms	ADIR2\|NUP196\|NUP96
Description	nucleoporin 98kDa
Reference	MIM:601021\|HGNC:HGNC:8068\|Ensembl:ENSG00000110713\|HPRD:03012\|Vega:OTTHUMG00000011846
Gene type	protein-coding
Map location	11p15.5
Pascal p-value	0.152
Fetal beta	0.39
eGene	Caudate basal ganglia
Support	CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DNM:McCarthy_2014	Whole Exome Sequencing analysis	Whole exome sequencing of 57 trios with sporadic or familial schizophrenia.

Section I. Genetics and epigenetics annotation

DNM table

Gene	Chromosome	Position	Ref	Alt	Transcript	AA change	Mutation type	Sift	CG46	Trait	Study
NUP98	chr11	3697753	G	C	NM_139132	p.R1650P	missense SNV	C	P	Schizophrenia	DNM:McCarthy_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	-	HPRD,BioGRID	9858599
EP300	KAT3B \| p300	E1A binding protein p300	Affinity Capture-Western	BioGRID	9858599
IPO5	DKFZp686O1576 \| FLJ43041 \| IMB3 \| KPNB3 \| MGC2068 \| RANBP5	importin 5	-	HPRD	9114010
KPNB1	IMB1 \| IPOB \| Impnb \| MGC2155 \| MGC2156 \| MGC2157 \| NTF97	karyopherin (importin) beta 1	-	HPRD,BioGRID	9144189
MOBKL1B	C2orf6 \| FLJ10788 \| FLJ11595 \| MATS1 \| MOB1 \| MOBK1B \| Mob4B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	Affinity Capture-MS	BioGRID	17353931
NFX1	DKFZp779G2416 \| MGC20369 \| NFX2	nuclear transcription factor, X-box binding 1	Reconstituted Complex	BioGRID	11073998
NUP133	FLJ10814 \| MGC21133 \| hNUP133	nucleoporin 133kDa	-	HPRD,BioGRID	11564755
NUP214	CAIN \| CAN \| D9S46E \| MGC104525 \| N214	nucleoporin 214kDa	-	HPRD	12589057
NUP62	DKFZp547L134 \| FLJ20822 \| FLJ43869 \| IBSN \| MGC841 \| SNDI \| p62	nucleoporin 62kDa	-	HPRD	8707840
NUP88	MGC8530	nucleoporin 88kDa	-	HPRD,BioGRID	12589057
NUP98	ADIR2 \| NUP196 \| NUP96	nucleoporin 98kDa	-	HPRD	12589057
NXF1	DKFZp667O0311 \| MEX67 \| TAP	nuclear RNA export factor 1	-	HPRD	10668806
NXF1	DKFZp667O0311 \| MEX67 \| TAP	nuclear RNA export factor 1	Reconstituted Complex	BioGRID	11551912
PARP11	C12orf6 \| DKFZp779H0122	poly (ADP-ribose) polymerase family, member 11	Affinity Capture-MS	BioGRID	17353931
QRICH2	DKFZp434P0316	glutamine rich 2	Affinity Capture-MS	BioGRID	17353931
RAE1	FLJ30608 \| MGC117333 \| MGC126076 \| MGC126077 \| MIG14 \| MRNP41 \| Mnrp41 \| dJ481F12.3 \| dJ800J21.1	RAE1 RNA export 1 homolog (S. pombe)	-	HPRD,BioGRID	10209021
TNPO1	IPO2 \| KPNB2 \| MIP \| MIP1 \| TRN	transportin 1	-	HPRD,BioGRID	9144189\|10875935
TNPO2	FLJ12155 \| IPO3 \| KPNB2B \| TRN2	transportin 2 (importin 3, karyopherin beta 2b)	Reconstituted Complex	BioGRID	10875935
TPR	-	translocated promoter region (to activated MET oncogene)	-	HPRD,BioGRID	11248057

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN	310	188	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN	146	94	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA BY DMOG DN	59	40	All SZGR 2.0 genes in this pathway
KLEIN TARGETS OF BCR ABL1 FUSION	45	34	All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM	159	93	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN	169	102	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN	187	122	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN	289	166	All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO HD MTX DN	24	18	All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN	169	112	All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN	245	154	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH 6Q21 DELETION	20	15	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP	390	242	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP	314	201	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP	178	111	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN	287	208	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP	148	96	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN	373	196	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE UP	79	40	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G6 DN	19	13	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M	216	124	All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1	467	251	All SZGR 2.0 genes in this pathway

Gene Page: NUP98