Gene Page: P4HB

Summary
GeneID  5034
Symbol  P4HB
Synonyms  DSI|ERBA2L|GIT|PDI|PDIA1|PHDB|PO4DB|PO4HB|PROHB
Description  procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
See related  HGNC:8548|MIM:176790|Ensembl:ENSG00000185624|HPRD:07181|
Locus tag  -
Gene type  protein-coding
Map location  17q25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.7758 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ICMT0.840.81
SPOCK20.800.78
SLC7A80.790.84
INPP4B0.790.77
PEG3AS0.780.75
KIAA1324L0.780.77
RNF60.780.80
SGPP20.780.74
SRPR0.780.84
CYLD0.780.79
Top 10 negatively co-expressed genes
EMID1-0.39-0.41
KLHL1-0.37-0.04
WDR86-0.37-0.36
SCUBE1-0.36-0.30
SLA-0.36-0.02
DACT1-0.36-0.03
TMEM108-0.35-0.09
MPPED1-0.35-0.13
NEUROD2-0.35-0.14
NEUROD6-0.34-0.17
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003756protein disulfide isomerase activityTAS2846539 
GO:0005515protein bindingIPI17055437 |17353931 
GO:0004656procollagen-proline 4-dioxygenase activityIDA7753822 
GO:0016853isomerase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0018401peptidyl-proline hydroxylation to 4-hydroxy-L-prolineIDA7753822 
GO:0045454cell redox homeostasisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeIEA-
GO:0005793ER-Golgi intermediate compartmentIDA15308636 
GO:0005788endoplasmic reticulum lumenIEA-
GO:0005576extracellular regionNAS14718574 
GO:0005783endoplasmic reticulumIEA-
GO:0005783endoplasmic reticulumTAS3034602 
GO:0009986cell surfaceIDA12493773 
GO:0005886plasma membraneIEA-
GO:0042470melanosomeIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD2BP2FWP010 | LIN1 | Snu40 | U5-52KCD2 (cytoplasmic tail) binding protein 2Affinity Capture-MSBioGRID17353931 
COL1A1OI4collagen, type I, alpha 1-HPRD1339453 
COL1A2OI4collagen, type I, alpha 2-HPRD,BioGRID10329688 
CUL2MGC131970cullin 2Affinity Capture-MSBioGRID17353931 
EIF4A2BM-010 | DDX2B | EIF4A | EIF4Feukaryotic translation initiation factor 4A, isoform 2Affinity Capture-MSBioGRID17353931 
ELF3EPR-1 | ERT | ESE-1 | ESXE74-like factor 3 (ets domain transcription factor, epithelial-specific )Affinity Capture-MSBioGRID17353931 
ERO1LERO1-alphaERO1-like (S. cerevisiae)-HPRD,BioGRID11707400 
ERO1LB-ERO1-like beta (S. cerevisiae)-HPRD,BioGRID11847130 
FEZ1-fasciculation and elongation protein zeta 1 (zygin I)Two-hybridBioGRID16169070 
P4HA2-procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II-HPRD7753822 
P4HA3-procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III-HPRD12874193 |14500733 
PTNHARP | HBGF8 | HBNF | NEGF1pleiotrophinTwo-hybridBioGRID16169070 
PUF60FIR | FLJ31379 | RoBPI | SIAHBP1poly-U binding splicing factor 60KDaAffinity Capture-MSBioGRID17353931 
TGAITD3 | TGNthyroglobulin-HPRD,BioGRID10636893 
TNFRSF14ATAR | HVEA | HVEM | LIGHTR | TR2tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)Affinity Capture-MSBioGRID17353931 
TRIP6MGC10556 | MGC10558 | MGC29959 | MGC3837 | MGC4423 | OIP1 | ZRP-1thyroid hormone receptor interactor 6Affinity Capture-MSBioGRID17353931 
UBQLN1DA41 | DSK2 | FLJ90054 | PLIC-1 | XDRP1ubiquilin 1-HPRD,BioGRID12095988 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_HIF_PATHWAY 1512All SZGR genes in this pathway
BIOCARTA_VITCB_PATHWAY 116All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION 8742All SZGR genes in this pathway
REACTOME_COLLAGEN_FORMATION 5831All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 4637All SZGR genes in this pathway
REACTOME_LIPOPROTEIN_METABOLISM 2824All SZGR genes in this pathway
REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT 1615All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_DN 214133All SZGR genes in this pathway
CHOW_RASSF1_TARGETS_DN 2919All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_UP 181108All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
LI_LUNG_CANCER 4130All SZGR genes in this pathway
LI_AMPLIFIED_IN_LUNG_CANCER 178108All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC 10874All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
LIEN_BREAST_CARCINOMA_METAPLASTIC 3525All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_UP 283177All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_UP 7851All SZGR genes in this pathway
ROSS_AML_WITH_PML_RARA_FUSION 7762All SZGR genes in this pathway
CHEN_LUNG_CANCER_SURVIVAL 2822All SZGR genes in this pathway
SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_UP 4530All SZGR genes in this pathway
GALE_APL_WITH_FLT3_MUTATED_DN 1710All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP 222139All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
RAMASWAMY_METASTASIS_UP 6643All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_FIBROBLAST 13293All SZGR genes in this pathway
CAMPS_COLON_CANCER_COPY_NUMBER_UP 9245All SZGR genes in this pathway
SMID_BREAST_CANCER_ERBB2_UP 14783All SZGR genes in this pathway
QI_PLASMACYTOMA_DN 10063All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
VALK_AML_CLUSTER_12 3020All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP 181106All SZGR genes in this pathway
NGO_MALIGNANT_GLIOMA_1P_LOH 1713All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_DN 14688All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-188201207m8hsa-miR-188CAUCCCUUGCAUGGUGGAGGGU
miR-204/211200206m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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