Gene Page: PAX4
Summary ?
| GeneID | 5078 |
| Symbol | PAX4 |
| Synonyms | KPD|MODY9 |
| Description | paired box 4 |
| Reference | MIM:167413|HGNC:HGNC:8618|Ensembl:ENSG00000106331|HPRD:01333|Vega:OTTHUMG00000157562 |
| Gene type | protein-coding |
| Map location | 7q32 |
| Pascal p-value | 0.024 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10994209 | chr10 | 61877705 | PAX4 | 5078 | 0.13 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ATL1 | 0.94 | 0.94 |
| YWHAH | 0.92 | 0.91 |
| C2orf30 | 0.91 | 0.90 |
| MOAP1 | 0.91 | 0.92 |
| SUCLA2 | 0.90 | 0.91 |
| IQWD1 | 0.90 | 0.88 |
| MAPRE3 | 0.90 | 0.90 |
| FBXO34 | 0.90 | 0.85 |
| ATP6AP2 | 0.89 | 0.89 |
| MAPK9 | 0.89 | 0.90 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.18 | -0.55 | -0.34 |
| AF347015.21 | -0.53 | -0.28 |
| AF347015.26 | -0.50 | -0.26 |
| AF347015.2 | -0.49 | -0.25 |
| IL32 | -0.49 | -0.32 |
| AP002478.3 | -0.49 | -0.41 |
| MT-CO2 | -0.48 | -0.28 |
| RAB34 | -0.47 | -0.49 |
| AC098691.2 | -0.47 | -0.36 |
| AF347015.8 | -0.47 | -0.27 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG MATURITY ONSET DIABETES OF THE YOUNG | 25 | 19 | All SZGR 2.0 genes in this pathway |
| RIZ ERYTHROID DIFFERENTIATION | 77 | 51 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | All SZGR 2.0 genes in this pathway |
| ZHOU PANCREATIC ENDOCRINE PROGENITOR | 14 | 11 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF LCP WITH H3K27ME3 | 70 | 35 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| ROLEF GLIS3 TARGETS | 37 | 29 | All SZGR 2.0 genes in this pathway |