Gene Page: PARD6A

Summary ?
GeneID50855
SymbolPARD6A
SynonymsPAR-6A|PAR6|PAR6C|PAR6alpha|TAX40|TIP-40
Descriptionpar-6 family cell polarity regulator alpha
ReferenceMIM:607484|HGNC:HGNC:15943|Ensembl:ENSG00000102981|HPRD:06316|Vega:OTTHUMG00000137534
Gene typeprotein-coding
Map location16q22.1
Pascal p-value0.011
Sherlock p-value0.466

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0447 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg269191001667695516PARD6A;ACD4.62E-60.5420.01DMG:Wockner_2014
cg088344291667694862ACD;PARD6A1.09E-5-0.2880.013DMG:Wockner_2014
cg046070241667696204PARD6A;ACD5.47E-50.4120.022DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008134transcription factor bindingTAS9482110 
GO:0017048Rho GTPase bindingISS-
GO:0030742GTP-dependent protein bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0016032viral reproductionTAS9482110 
GO:0007049cell cycleIEA-
GO:0051301cell divisionIEA-
GO:0045217cell-cell junction maintenanceISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0005923tight junctionISSBrain (GO term level: 10)-
GO:0005634nucleusISS-
GO:0005737cytoplasmIEA-
GO:0005938cell cortexIEA-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID10873802 |10934474 
|11260256 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD10873802|11260256 
CRB3-crumbs homolog 3 (Drosophila)-HPRD14718572 
ECT2FLJ10461 | MGC138291epithelial cell transforming sequence 2 oncogene-HPRD,BioGRID15254234 
MPP5FLJ12615 | PALS1membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)Affinity Capture-WesternBioGRID12545177 
PARD3ASIP | Baz | Bazooka | FLJ21015 | PAR3 | PAR3alpha | PARD3A | SE2-5L16 | SE2-5LT1 | SE2-5T2par-3 partitioning defective 3 homolog (C. elegans)Affinity Capture-WesternBioGRID12459187 
PLCB1FLJ45792 | PI-PLC | PLC-154 | PLC-I | PLC154phospholipase C, beta 1 (phosphoinositide-specific)PLCB1 (PLC-beta-1) interacts with PARD6A (Par6). This interaction was modeled on a demonstrated interaction between rat PLCB1 and human Par6.BIND15782111 
PLCB3FLJ37084phospholipase C, beta 3 (phosphatidylinositol-specific)PLCB3 (PLC-beta-3) interacts with PARD6A (Par6)BIND15782111 
PRKCIDXS1179E | MGC26534 | PKCI | nPKC-iotaprotein kinase C, iotaTwo-hybridBioGRID16189514 
PRKCZPKC-ZETA | PKC2protein kinase C, zeta-HPRD,BioGRID11260256 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD,BioGRID11260256 
RHOQARHQ | RASL7A | TC10 | TC10Aras homolog gene family, member QTwo-hybridBioGRID10934474 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 13486All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES 6754All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES 5141All SZGR 2.0 genes in this pathway
PID RHOA PATHWAY 4533All SZGR 2.0 genes in this pathway
PID INSULIN PATHWAY 4532All SZGR 2.0 genes in this pathway
PID MET PATHWAY 8060All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY 7051All SZGR 2.0 genes in this pathway
PID NEPHRIN NEPH1 PATHWAY 3124All SZGR 2.0 genes in this pathway
PID TGFBR PATHWAY 5538All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION 12077All SZGR 2.0 genes in this pathway
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 167All SZGR 2.0 genes in this pathway
REACTOME CELL CELL JUNCTION ORGANIZATION 5631All SZGR 2.0 genes in this pathway
REACTOME TIGHT JUNCTION INTERACTIONS 2911All SZGR 2.0 genes in this pathway
REACTOME CELL JUNCTION ORGANIZATION 7843All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 6342All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201125All SZGR 2.0 genes in this pathway
KIM RESPONSE TO TSA AND DECITABINE UP 12973All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
WATTEL AUTONOMOUS THYROID ADENOMA UP 7347All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637377All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS DN 6639All SZGR 2.0 genes in this pathway
MARCINIAK ER STRESS RESPONSE VIA CHOP 2517All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295155All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN 180116All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS DN 211119All SZGR 2.0 genes in this pathway