Gene Page: PARD6A
Summary ?
GeneID | 50855 |
Symbol | PARD6A |
Synonyms | PAR-6A|PAR6|PAR6C|PAR6alpha|TAX40|TIP-40 |
Description | par-6 family cell polarity regulator alpha |
Reference | MIM:607484|HGNC:HGNC:15943|Ensembl:ENSG00000102981|HPRD:06316|Vega:OTTHUMG00000137534 |
Gene type | protein-coding |
Map location | 16q22.1 |
Pascal p-value | 0.011 |
Sherlock p-value | 0.466 |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 3 |
GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 2 | |
Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0447 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg26919100 | 16 | 67695516 | PARD6A;ACD | 4.62E-6 | 0.542 | 0.01 | DMG:Wockner_2014 |
cg08834429 | 16 | 67694862 | ACD;PARD6A | 1.09E-5 | -0.288 | 0.013 | DMG:Wockner_2014 |
cg04607024 | 16 | 67696204 | PARD6A;ACD | 5.47E-5 | 0.412 | 0.022 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0008134 | transcription factor binding | TAS | 9482110 | |
GO:0017048 | Rho GTPase binding | ISS | - | |
GO:0030742 | GTP-dependent protein binding | ISS | - | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0016032 | viral reproduction | TAS | 9482110 | |
GO:0007049 | cell cycle | IEA | - | |
GO:0051301 | cell division | IEA | - | |
GO:0045217 | cell-cell junction maintenance | ISS | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0042995 | cell projection | IEA | axon (GO term level: 4) | - |
GO:0005923 | tight junction | ISS | Brain (GO term level: 10) | - |
GO:0005634 | nucleus | ISS | - | |
GO:0005737 | cytoplasm | IEA | - | |
GO:0005938 | cell cortex | IEA | - | |
GO:0005886 | plasma membrane | IEA | - | |
GO:0030054 | cell junction | IEA | - |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
CDC42 | CDC42Hs | G25K | cell division cycle 42 (GTP binding protein, 25kDa) | Affinity Capture-Western in vitro in vivo Reconstituted Complex Two-hybrid | BioGRID | 10873802 |10934474 |11260256 |
CDC42 | CDC42Hs | G25K | cell division cycle 42 (GTP binding protein, 25kDa) | - | HPRD | 10873802|11260256 |
CRB3 | - | crumbs homolog 3 (Drosophila) | - | HPRD | 14718572 |
ECT2 | FLJ10461 | MGC138291 | epithelial cell transforming sequence 2 oncogene | - | HPRD,BioGRID | 15254234 |
MPP5 | FLJ12615 | PALS1 | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) | Affinity Capture-Western | BioGRID | 12545177 |
PARD3 | ASIP | Baz | Bazooka | FLJ21015 | PAR3 | PAR3alpha | PARD3A | SE2-5L16 | SE2-5LT1 | SE2-5T2 | par-3 partitioning defective 3 homolog (C. elegans) | Affinity Capture-Western | BioGRID | 12459187 |
PLCB1 | FLJ45792 | PI-PLC | PLC-154 | PLC-I | PLC154 | phospholipase C, beta 1 (phosphoinositide-specific) | PLCB1 (PLC-beta-1) interacts with PARD6A (Par6). This interaction was modeled on a demonstrated interaction between rat PLCB1 and human Par6. | BIND | 15782111 |
PLCB3 | FLJ37084 | phospholipase C, beta 3 (phosphatidylinositol-specific) | PLCB3 (PLC-beta-3) interacts with PARD6A (Par6) | BIND | 15782111 |
PRKCI | DXS1179E | MGC26534 | PKCI | nPKC-iota | protein kinase C, iota | Two-hybrid | BioGRID | 16189514 |
PRKCZ | PKC-ZETA | PKC2 | protein kinase C, zeta | - | HPRD,BioGRID | 11260256 |
RAC1 | MGC111543 | MIG5 | TC-25 | p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | - | HPRD,BioGRID | 11260256 |
RHOQ | ARHQ | RASL7A | TC10 | TC10A | ras homolog gene family, member Q | Two-hybrid | BioGRID | 10934474 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG ENDOCYTOSIS | 183 | 132 | All SZGR 2.0 genes in this pathway |
KEGG TIGHT JUNCTION | 134 | 86 | All SZGR 2.0 genes in this pathway |
SIG PIP3 SIGNALING IN CARDIAC MYOCTES | 67 | 54 | All SZGR 2.0 genes in this pathway |
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | 51 | 41 | All SZGR 2.0 genes in this pathway |
PID RHOA PATHWAY | 45 | 33 | All SZGR 2.0 genes in this pathway |
PID INSULIN PATHWAY | 45 | 32 | All SZGR 2.0 genes in this pathway |
PID MET PATHWAY | 80 | 60 | All SZGR 2.0 genes in this pathway |
PID CDC42 PATHWAY | 70 | 51 | All SZGR 2.0 genes in this pathway |
PID NEPHRIN NEPH1 PATHWAY | 31 | 24 | All SZGR 2.0 genes in this pathway |
PID TGFBR PATHWAY | 55 | 38 | All SZGR 2.0 genes in this pathway |
REACTOME CELL CELL COMMUNICATION | 120 | 77 | All SZGR 2.0 genes in this pathway |
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | 16 | 7 | All SZGR 2.0 genes in this pathway |
REACTOME CELL CELL JUNCTION ORGANIZATION | 56 | 31 | All SZGR 2.0 genes in this pathway |
REACTOME TIGHT JUNCTION INTERACTIONS | 29 | 11 | All SZGR 2.0 genes in this pathway |
REACTOME CELL JUNCTION ORGANIZATION | 78 | 43 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX | 63 | 42 | All SZGR 2.0 genes in this pathway |
HOLLMANN APOPTOSIS VIA CD40 UP | 201 | 125 | All SZGR 2.0 genes in this pathway |
KIM RESPONSE TO TSA AND DECITABINE UP | 129 | 73 | All SZGR 2.0 genes in this pathway |
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
WATTEL AUTONOMOUS THYROID ADENOMA UP | 73 | 47 | All SZGR 2.0 genes in this pathway |
NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | 637 | 377 | All SZGR 2.0 genes in this pathway |
SWEET KRAS TARGETS DN | 66 | 39 | All SZGR 2.0 genes in this pathway |
MARCINIAK ER STRESS RESPONSE VIA CHOP | 25 | 17 | All SZGR 2.0 genes in this pathway |
MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
LU EZH2 TARGETS UP | 295 | 155 | All SZGR 2.0 genes in this pathway |
PURBEY TARGETS OF CTBP1 AND SATB1 DN | 180 | 116 | All SZGR 2.0 genes in this pathway |
FOSTER KDM1A TARGETS DN | 211 | 119 | All SZGR 2.0 genes in this pathway |