Gene Page: EXOSC4

Summary ?
GeneID54512
SymbolEXOSC4
SynonymsRRP41|RRP41A|Rrp41p|SKI6|Ski6p|hRrp41p|p12A
Descriptionexosome component 4
ReferenceMIM:606491|HGNC:HGNC:18189|Ensembl:ENSG00000178896|HPRD:16221|Vega:OTTHUMG00000165437
Gene typeprotein-coding
Map location8q24.3
Pascal p-value0.824
Fetal beta-0.251
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
ExpressionMeta-analysis of gene expressionP value: 1.385 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg240283818145133668EXOSC44.54E-5-0.3010.021DMG:Wockner_2014
cg257880128145133899EXOSC41.398E-4-0.2480.031DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:00001753'-5'-exoribonuclease activityNAS11110791 
GO:0003723RNA bindingIEA-
GO:0005515protein bindingIPI15231747 
GO:0004527exonuclease activityIEA-
GO:0016787hydrolase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006396RNA processingIEA-
GO:0006364rRNA processingNAS11110791 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000178exosome (RNase complex)IEA-
GO:0005634nucleusIEA-
GO:0005730nucleolusNAS11110791 
GO:0005737cytoplasmNAS11110791 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKR1A1ALDR1 | ALR | ARM | DD3 | MGC12529 | MGC1380aldo-keto reductase family 1, member A1 (aldehyde reductase)-HPRD,BioGRID15231747 
DOM3ZDOM3L | NG6dom-3 homolog Z (C. elegans)-HPRD15231747 
EEF1A1CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1eukaryotic translation elongation factor 1 alpha 1-HPRD,BioGRID15231747 
EXOSC1CGI-108 | CSL4 | Csl4p | SKI4 | Ski4p | hCsl4p | p13exosome component 1-HPRD11110791 |12419256 
EXOSC1CGI-108 | CSL4 | Csl4p | SKI4 | Ski4p | hCsl4p | p13exosome component 1hCsl4p interacts with hRrp41p.BIND12419256 
EXOSC10PM-Scl | PM/Scl-100 | PMSCL | PMSCL2 | RRP6 | Rrp6p | p2 | p3 | p4exosome component 10-HPRD15231747 
EXOSC2RRP4 | Rrp4p | hRrp4p | p7exosome component 2-HPRD12419256 
EXOSC2RRP4 | Rrp4p | hRrp4p | p7exosome component 2-HPRD11719186 
EXOSC2RRP4 | Rrp4p | hRrp4p | p7exosome component 2hRrp4p interacts with hRrp41p.BIND12419256 
EXOSC3CGI-102 | MGC15120 | MGC723 | RP11-3J10.8 | RRP40 | Rrp40p | bA3J10.7 | hRrp40p | p10exosome component 3-HPRD11110791 |12419256 
EXOSC4FLJ20591 | RRP41 | RRP41A | Rrp41p | SKI6 | Ski6p | hRrp41p | p12Aexosome component 4hRrp41p interacts with another hRrp41p.BIND12419256 
EXOSC4FLJ20591 | RRP41 | RRP41A | Rrp41p | SKI6 | Ski6p | hRrp41p | p12Aexosome component 4-HPRD12419256 
EXOSC7EAP1 | FLJ26543 | KIAA0116 | RRP42 | Rrp42p | hRrp42p | p8exosome component 7hRrp42p interacts with hRrp41p.BIND12419256 
EXOSC9PM/Scl-75 | PMSCL1 | RRP45 | Rrp45p | p5 | p6exosome component 9PM/Scl-75c-alpha interacts with hRrp41p.BIND12788944 
GADD45GIP1CKBBP2 | CRIF1 | MGC4667 | MGC4758 | PLINP-1 | PRG6 | Plinp1growth arrest and DNA-damage-inducible, gamma interacting protein 1-HPRD15231747 
GTF2IRD1BEN | CREAM1 | GTF3 | MUSTRD1 | RBAP2 | WBS | WBSCR11 | WBSCR12 | hMusTRD1alpha1GTF2I repeat domain containing 1-HPRD,BioGRID15231747 
LRRC8DFLJ10470 | FLJ20403 | LRRC5leucine rich repeat containing 8 family, member D-HPRD15231747 
MPZL1FLJ21047 | PZR | PZR1b | PZRa | PZRbmyelin protein zero-like 1-HPRD15231747 
NEK1DKFZp686D06121 | DKFZp686K12169 | KIAA1901 | MGC138800 | NY-REN-55NIMA (never in mitosis gene a)-related kinase 1-HPRD15231747 
SKIV2L170A | DDX13 | HLP | SKI2 | SKI2W | SKIV2superkiller viralicidic activity 2-like (S. cerevisiae)-HPRD15231747 
SMPD4FLJ20297 | FLJ20756 | KIAA1418 | NSMASE3 | nSMase-3sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)-HPRD15231747 
UPF1FLJ43809 | FLJ46894 | HUPF1 | KIAA0221 | NORF1 | RENT1 | pNORF1UPF1 regulator of nonsense transcripts homolog (yeast)-HPRD,BioGRID14527413 
UPF2DKFZp434D222 | HUPF2 | KIAA1408 | MGC138834 | MGC138835 | RENT2 | smg-3UPF2 regulator of nonsense transcripts homolog (yeast)-HPRD,BioGRID14527413 
UPF3AHUPF3A | RENT3A | UPF3UPF3 regulator of nonsense transcripts homolog A (yeast)Affinity Capture-WesternBioGRID14527413 
UPF3BHUPF3B | MRXS14 | RENT3B | UPF3XUPF3 regulator of nonsense transcripts homolog B (yeast)-HPRD14527413 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG RNA DEGRADATION 5937All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
REACTOME PERK REGULATED GENE EXPRESSION 2914All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF GENES BY ATF4 2612All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE 8051All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284128All SZGR 2.0 genes in this pathway
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 115All SZGR 2.0 genes in this pathway
REACTOME DEADENYLATION DEPENDENT MRNA DECAY 4829All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330155All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY BRF1 179All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 8450All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY KSRP 179All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP 177All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS DN 182111All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384220All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP 368234All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS GREY DN 7444All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276165All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380236All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418263All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP 341197All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187115All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN 14694All SZGR 2.0 genes in this pathway
CHOW RASSF1 TARGETS DN 2919All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL 11662All SZGR 2.0 genes in this pathway
OXFORD RALA OR RALB TARGETS UP 4823All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637377All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 24HR 5 UP 3423All SZGR 2.0 genes in this pathway
SUH COEXPRESSED WITH ID1 AND ID2 UP 1914All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q23 Q24 AMPLICON 15787All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC 210123All SZGR 2.0 genes in this pathway
YEGNASUBRAMANIAN PROSTATE CANCER 12860All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298174All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456287All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374217All SZGR 2.0 genes in this pathway
LI DCP2 BOUND MRNA 8957All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway