Gene Page: PINX1
Summary ?
| GeneID | 54984 |
| Symbol | PINX1 |
| Synonyms | LPTL|LPTS |
| Description | PIN2/TERF1 interacting, telomerase inhibitor 1 |
| Reference | MIM:606505|HGNC:HGNC:30046|Ensembl:ENSG00000254093|HPRD:05934|Vega:OTTHUMG00000163808 |
| Gene type | protein-coding |
| Map location | 8p23 |
| Pascal p-value | 0.002 |
| Sherlock p-value | 0.345 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0274 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C3orf17 | 0.75 | 0.74 |
| MRPS22 | 0.73 | 0.71 |
| ACP1 | 0.72 | 0.70 |
| CRBN | 0.72 | 0.69 |
| EBAG9 | 0.72 | 0.69 |
| C5orf44 | 0.72 | 0.71 |
| PAIP2 | 0.72 | 0.74 |
| LIAS | 0.71 | 0.72 |
| ERGIC2 | 0.71 | 0.73 |
| COPS4 | 0.71 | 0.70 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.18 | -0.52 | -0.41 |
| AF347015.2 | -0.49 | -0.36 |
| AF347015.26 | -0.49 | -0.38 |
| MT-CYB | -0.47 | -0.39 |
| AF347015.8 | -0.47 | -0.38 |
| MT-CO2 | -0.46 | -0.37 |
| AF347015.15 | -0.46 | -0.39 |
| AF347015.21 | -0.45 | -0.31 |
| MT-ATP8 | -0.43 | -0.34 |
| AF347015.31 | -0.42 | -0.36 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003674 | molecular_function | ND | - | |
| GO:0003676 | nucleic acid binding | IEA | - | |
| GO:0005515 | protein binding | IPI | 17353931 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0008285 | negative regulation of cell proliferation | NAS | 11003615 | |
| GO:0007004 | telomere maintenance via telomerase | IEA | - | |
| GO:0045786 | negative regulation of cell cycle | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0000781 | chromosome, telomeric region | IEA | - | |
| GO:0005575 | cellular_component | ND | - | |
| GO:0005622 | intracellular | IEA | - | |
| GO:0005634 | nucleus | IEA | - | |
| GO:0005694 | chromosome | IEA | - | |
| GO:0005730 | nucleolus | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| AHCY | SAHH | S-adenosylhomocysteine hydrolase | Affinity Capture-MS | BioGRID | 17353931 |
| CALM3 | PHKD | PHKD3 | calmodulin 3 (phosphorylase kinase, delta) | Affinity Capture-MS | BioGRID | 17353931 |
| CAPRIN1 | GPIAP1 | GPIP137 | M11S1 | caprin-1 | p137GPI | cell cycle associated protein 1 | Affinity Capture-MS | BioGRID | 17353931 |
| GTPBP4 | CRFG | FLJ10686 | FLJ10690 | FLJ39774 | NGB | NOG1 | GTP binding protein 4 | Affinity Capture-MS | BioGRID | 17353931 |
| HRNR | S100A16 | S100a18 | hornerin | Affinity Capture-MS | BioGRID | 17353931 |
| MCRS1 | ICP22BP | INO80Q | MCRS2 | MSP58 | P78 | microspherule protein 1 | - | HPRD,BioGRID | 15044100 |
| PABPC1 | PAB1 | PABP | PABP1 | PABPC2 | PABPL1 | poly(A) binding protein, cytoplasmic 1 | Affinity Capture-MS | BioGRID | 17353931 |
| PABPC4 | APP-1 | APP1 | FLJ43938 | PABP4 | iPABP | poly(A) binding protein, cytoplasmic 4 (inducible form) | Affinity Capture-MS | BioGRID | 17353931 |
| PAFAH1B2 | - | platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa | Two-hybrid | BioGRID | 16169070 |
| PLEKHJ1 | FLJ10297 | GNRPX | pleckstrin homology domain containing, family J member 1 | Affinity Capture-MS | BioGRID | 17353931 |
| RPL23A | FLJ27455 | MDA20 | ribosomal protein L23a | Affinity Capture-MS | BioGRID | 17353931 |
| RPL31 | MGC88191 | ribosomal protein L31 | Affinity Capture-MS | BioGRID | 17353931 |
| RPS10 | MGC88819 | ribosomal protein S10 | Affinity Capture-MS | BioGRID | 17353931 |
| RPS16 | - | ribosomal protein S16 | Affinity Capture-MS | BioGRID | 17353931 |
| RPS19 | DBA | ribosomal protein S19 | Affinity Capture-MS | BioGRID | 17353931 |
| RPS28 | - | ribosomal protein S28 | Affinity Capture-MS | BioGRID | 17353931 |
| RPS3A | FTE1 | MFTL | MGC23240 | ribosomal protein S3A | Affinity Capture-MS | BioGRID | 17353931 |
| TERF1 | FLJ41416 | PIN2 | TRBF1 | TRF | TRF1 | hTRF1-AS | t-TRF1 | telomeric repeat binding factor (NIMA-interacting) 1 | - | HPRD,BioGRID | 11701125 |
| TERT | EST2 | TCS1 | TP2 | TRT | hEST2 | telomerase reverse transcriptase | - | HPRD,BioGRID | 11701125 |
| TXN | DKFZp686B1993 | MGC61975 | TRX | TRX1 | thioredoxin | Affinity Capture-MS | BioGRID | 17353931 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID TELOMERASE PATHWAY | 68 | 48 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP | 167 | 92 | All SZGR 2.0 genes in this pathway |
| SHEPARD CRUSH AND BURN MUTANT UP | 197 | 110 | All SZGR 2.0 genes in this pathway |
| MATSUDA NATURAL KILLER DIFFERENTIATION | 475 | 313 | All SZGR 2.0 genes in this pathway |
| HESS TARGETS OF HOXA9 AND MEIS1 UP | 65 | 44 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS EARLY PROGENITOR | 532 | 309 | All SZGR 2.0 genes in this pathway |
| MARZEC IL2 SIGNALING UP | 115 | 80 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE EARLY LATE | 317 | 190 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |