Gene Page: PKIB

Summary ?
GeneID5570
SymbolPKIB
SynonymsPRKACN2
Descriptionprotein kinase (cAMP-dependent, catalytic) inhibitor beta
ReferenceMIM:606914|HGNC:HGNC:9018|Ensembl:ENSG00000135549|HPRD:06075|Vega:OTTHUMG00000015488
Gene typeprotein-coding
Map location6q22.31
Pascal p-value0.024
Fetal beta-2.387
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg039022336122792987PKIB;SERINC11.358E-4-0.3380.031DMG:Wockner_2014
cg202422106122931702PKIB2.816E-4-0.1960.039DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1954436chr162248194PKIB55700.14trans
rs13447530chr191983798PKIB55700.09trans
rs17022378chr1206654057PKIB55700.05trans
rs6734526chr25616370PKIB55700.16trans
rs6753473chr226526418PKIB55700.03trans
rs17028363chr241913161PKIB55700trans
rs16829545chr2151977407PKIB55701.061E-40trans
rs16841750chr2158288461PKIB55702.226E-4trans
rs16846743chr2163321013PKIB55700.17trans
rs16863816chr2177292762PKIB55700.03trans
rs7584986chr2184111432PKIB55703.741E-6trans
rs6741060chr2217169088PKIB55700.01trans
rs10183246chr2237187882PKIB55700.05trans
rs10195546chr2237187933PKIB55700.15trans
rs9810143chr35060209PKIB55702.828E-7trans
rs6797307chr38601563PKIB55700trans
rs4831224chr3115754105PKIB55700.14trans
rs6773248chr3174790333PKIB55700.06trans
rs6797728chr3174790417PKIB55700.06trans
rs12642340chr435390674PKIB55700.15trans
snp_a-18157710PKIB55700.02trans
rs7654426chr486236933PKIB55700.2trans
rs17008119chr4125321425PKIB55700.02trans
rs7692715chr4125335209PKIB55700trans
rs2183142chr4159232695PKIB55700.09trans
rs170776chr4173276735PKIB55700.05trans
rs1396222chr4173279496PKIB55700.03trans
rs335993chr4173321789PKIB55700.09trans
rs335980chr4173329784PKIB55700.02trans
rs335982chr4173330945PKIB55700.08trans
rs337984chr4173411662PKIB55700.18trans
rs4488887chr4177695833PKIB55700.08trans
rs10491487chr580323367PKIB55700.08trans
rs10474151chr584286402PKIB55700trans
rs133604960PKIB55700.01trans
rs13191953chr624151042PKIB55700.01trans
rs3789226chr624286501PKIB55700.1trans
rs6907864chr624293323PKIB55700.17trans
rs12196880chr624313746PKIB55700trans
rs10806988chr624341768PKIB55700trans
rs16890367chr638078448PKIB55709.85E-5trans
rs12706918chr780266147PKIB55700.05trans
rs7787830chr798797019PKIB55700.17trans
rs6996695chr877540580PKIB55701.254E-4trans
rs3118341chr925185518PKIB55700trans
rs1126130chr925209346PKIB55700.06trans
rs1998746chr925211761PKIB55700.06trans
rs9406868chr925223372PKIB55709.538E-4trans
rs11139334chr984209393PKIB55701.407E-4trans
rs2393316chr1059333070PKIB55700.03trans
rs17124813chr10110347464PKIB55700.08trans
rs11061703chr121436977PKIB55700.09trans
rs7972699chr12105155290PKIB55700.06trans
rs7488439chr12105155814PKIB55700.02trans
rs17036489chr12105292283PKIB55700.01trans
rs7337967chr1353519044PKIB55700.02trans
rs1530404chr1364207519PKIB55700.1trans
rs17289777chr1364223062PKIB55700.1trans
rs9989228chr1437809252PKIB55700.04trans
rs16955618chr1529937543PKIB55701.22E-36trans
rs2077735chr1558479024PKIB55700.02trans
rs9941296chr162759498PKIB55700.05trans
rs16945437chr1711797650PKIB55700.14trans
rs4795850chr1732383815PKIB55700.18trans
rs4795851chr1732384050PKIB55700.15trans
rs1003837chr1732453154PKIB55700.16trans
rs11873184chr181584081PKIB55702.111E-4trans
rs17681878chr1834767223PKIB55700.07trans
rs7274477chr201676942PKIB55700.01trans
rs1041786chr2122617710PKIB55702.129E-7trans
rs16986332chrX10958354PKIB55700.15trans
rs16990575chrX32691327PKIB55701.775E-4trans
rs16993189chrX144666166PKIB55700.02trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MAPK90.920.89
IQWD10.910.90
NAPB0.910.90
ATP6V1C10.900.89
IDH3A0.900.90
GABRA10.900.92
NSF0.900.88
GLRB0.900.86
PAK10.900.85
OXR10.890.91
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BCL7C-0.46-0.54
HYAL2-0.42-0.42
SH2D2A-0.42-0.45
SH3BP2-0.41-0.44
ANP32C-0.41-0.41
NME4-0.41-0.53
SLC38A5-0.40-0.45
CLEC3B-0.39-0.46
AF347015.18-0.39-0.18
FADS2-0.39-0.32

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004862cAMP-dependent protein kinase inhibitor activityIEA-
GO:0004860protein kinase inhibitor activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006469negative regulation of protein kinase activityIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408247All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367220All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP 175108All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN 232139All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS DN 13377All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291176All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329196All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM5 9459All SZGR 2.0 genes in this pathway
WILLIAMS ESR1 TARGETS UP 2616All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539324All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
UEDA CENTRAL CLOCK 8862All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP 222139All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307185All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258160All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN UP 181112All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE DN 7561All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE DN 7247All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567365All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229149All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324193All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211131All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281183All SZGR 2.0 genes in this pathway