SZGR2

Summary ?

GeneID	5595
Symbol	MAPK3
Synonyms	ERK-1\|ERK1\|ERT2\|HS44KDAP\|HUMKER1A\|P44ERK1\|P44MAPK\|PRKM3\|p44-ERK1\|p44-MAPK
Description	mitogen-activated protein kinase 3
Reference	MIM:601795\|HGNC:HGNC:6877\|Ensembl:ENSG00000102882\|HPRD:03479\|Vega:OTTHUMG00000132149
Gene type	protein-coding
Map location	16p11.2
Pascal p-value	1.32E-5
Sherlock p-value	0.474
Fetal beta	-1.207
eGene	Cortex Frontal Cortex BA9 Meta
Support	CANABINOID DOPAMINE INTRACELLULAR SIGNAL TRANSDUCTION METABOTROPIC GLUTAMATE RECEPTOR SEROTONIN G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.humanNRC G2Cdb.humanPSP CompositeSet Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CNV:YES	Copy number variation studies	Manual curation
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.01775
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.1437

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SLC16A12	0.74	0.59
RBM47	0.71	0.50
KCNJ13	0.70	0.31
CP	0.68	0.11
SLC35F5	0.67	0.64
SLC5A5	0.67	0.21
SLC13A4	0.66	0.19
PRLR	0.65	0.43
ABCA4	0.65	0.28
ANO6	0.65	0.68

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.21	-0.35	-0.42
AC018755.7	-0.34	-0.48
MT-CO2	-0.33	-0.47
ENHO	-0.33	-0.47
MT1G	-0.32	-0.45
CXCL14	-0.32	-0.42
IFI27	-0.32	-0.44
AL022328.1	-0.32	-0.35
S100A13	-0.32	-0.42
AF347015.33	-0.31	-0.43

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0004707	MAP kinase activity	EXP		11741541
GO:0004707	MAP kinase activity	IEA		-
GO:0004707	MAP kinase activity	NAS		7687743
GO:0005515	protein binding	IPI		15950189
GO:0005524	ATP binding	IEA		-
GO:0005524	ATP binding	NAS		-
GO:0004672	protein kinase activity	IEA		-
GO:0004674	protein serine/threonine kinase activity	EXP		16626623
GO:0004674	protein serine/threonine kinase activity	IEA		-
GO:0016740	transferase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006468	protein amino acid phosphorylation	IDA		7687743
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0007265	Ras protein signal transduction	EXP		11520933
GO:0007049	cell cycle	IEA		-
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		7739560
GO:0005856	cytoskeleton	IDA		18029348
GO:0005575	cellular_component	ND		-
GO:0005634	nucleus	IDA		18029348
GO:0005654	nucleoplasm	EXP		9687510 \|11741541 \|16456541 \|16626623 \|17322878
GO:0005730	nucleolus	IDA		18029348

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARRB2	ARB2 \| ARR2 \| BARR2 \| DKFZp686L0365	arrestin, beta 2	Affinity Capture-Western	BioGRID	12473660
ATF2	CRE-BP1 \| CREB2 \| HB16 \| MGC111558 \| TREB7	activating transcription factor 2	ERK1 interacts with and phosphorylates ATF2.	BIND	9155018
ATP1A1	MGC3285 \| MGC51750	ATPase, Na+/K+ transporting, alpha 1 polypeptide	-	HPRD,BioGRID	15069082
AVPR2	ADHR \| DI1 \| DIR \| DIR3 \| MGC126533 \| MGC138386 \| NDI \| V2R	arginine vasopressin receptor 2	Affinity Capture-Western	BioGRID	12473660
BCL3	BCL4 \| D19S37	B-cell CLL/lymphoma 3	Erk1 interacts with and phosphorylates BCL-3.	BIND	15469820
BRAF	B-RAF1 \| BRAF1 \| FLJ95109 \| MGC126806 \| MGC138284 \| RAFB1	v-raf murine sarcoma viral oncogene homolog B1	Phenotypic Enhancement	BioGRID	10869359
C1QBP	GC1QBP \| HABP1 \| SF2p32 \| gC1Q-R \| gC1qR \| p32	complement component 1, q subcomponent binding protein	-	HPRD,BioGRID	11866440
CASP9	APAF-3 \| APAF3 \| CASPASE-9c \| ICE-LAP6 \| MCH6	caspase 9, apoptosis-related cysteine peptidase	-	HPRD	12792650
DAPK1	DAPK \| DKFZp781I035	death-associated protein kinase 1	DAPK interacts with Erk1.	BIND	15616583
DCC	CRC18 \| CRCR1	deleted in colorectal carcinoma	-	HPRD,BioGRID	11986622
DUSP1	CL100 \| HVH1 \| MKP-1 \| MKP1 \| PTPN10	dual specificity phosphatase 1	-	HPRD,BioGRID	11278799
DUSP10	MKP-5 \| MKP5	dual specificity phosphatase 10	-	HPRD	10597297
DUSP3	VHR	dual specificity phosphatase 3	-	HPRD,BioGRID	10224087
DUSP4	HVH2 \| MKP-2 \| MKP2 \| TYP	dual specificity phosphatase 4	Reconstituted Complex	BioGRID	11387337
DUSP4	HVH2 \| MKP-2 \| MKP2 \| TYP	dual specificity phosphatase 4	-	HPRD	7535768
DUSP5	DUSP \| HVH3	dual specificity phosphatase 5	-	HPRD,BioGRID	7836374
DUSP6	MKP3 \| PYST1	dual specificity phosphatase 6	-	HPRD,BioGRID	9535927
ELK1	-	ELK1, member of ETS oncogene family	Elk-1 is phosphorylated by ERK-1. This interaction was modeled on a demonstrated interaction between human Elk-1 and ERK-1 from an unspecified species.	BIND	9130707
ELK1	-	ELK1, member of ETS oncogene family	-	HPRD	8208531 \|12473660
ELK1	-	ELK1, member of ETS oncogene family	Mapk3 (p44Mapk) phosphorylates Elk1 at Ser383.	BIND	15782123
ELK1	-	ELK1, member of ETS oncogene family	ERK1 interacts with and phosphorylates Elk1. This interaction was modelled on a demonstrated interaction between rat ERK1 and human Elk1.	BIND	9235954
ELK1	-	ELK1, member of ETS oncogene family	Elk-1 is phosphorylated by ERK-1. This interaction was modeled on a demonstrated interaction between human Elk-1 and ERK-1 from an unspecified species.	BIND	9020136
ELK1	-	ELK1, member of ETS oncogene family	ERK1 interacts with and phosphorylates Elk-1.	BIND	9155018
ELK1	-	ELK1, member of ETS oncogene family	Erk1 phosphorylates Elk-1. This interaction was modeled on a demonstrated interaction between Erk1 and Elk-1 from an unspecified species.	BIND	10431817
ELK4	SAP1	ELK4, ETS-domain protein (SRF accessory protein 1)	Sap-1a is phosphorylated by ERK-1. This interaction was modeled on a demonstrated interaction between human Sap-1a and ERK-1 from an unspecified species.	BIND	9020136
ELK4	SAP1	ELK4, ETS-domain protein (SRF accessory protein 1)	Sap-1a is phosphorylated by ERK-1. This interaction was modeled on a demonstrated interaction between human Sap-1a and ERK-1 from an unspecified species.	BIND	9130707
EPOR	MGC138358	erythropoietin receptor	-	HPRD	12538595
ETV1	DKFZp781L0674 \| ER81 \| MGC104699 \| MGC120533 \| MGC120534	ets variant 1	Biochemical Activity	BioGRID	11551945
GATA4	MGC126629	GATA binding protein 4	-	HPRD	11585926
GMFB	GMF	glia maturation factor, beta	-	HPRD,BioGRID	8639570
GTF2I	BAP-135 \| BAP135 \| BTKAP1 \| DIWS \| FLJ38776 \| FLJ56355 \| IB291 \| SPIN \| TFII-I \| WBS \| WBSCR6	general transcription factor II, i	-	HPRD,BioGRID	10648599
HDAC4	HA6116 \| HD4 \| HDAC-A \| HDACA \| KIAA0288	histone deacetylase 4	-	HPRD,BioGRID	11114188
HIF1A	HIF-1alpha \| HIF1 \| HIF1-ALPHA \| MOP1 \| PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	-	HPRD	10551817
HMMR	CD168 \| IHABP \| MGC119494 \| MGC119495 \| RHAMM	hyaluronan-mediated motility receptor (RHAMM)	-	HPRD	11403955
HSF1	HSTF1	heat shock transcription factor 1	ERK1 interacts with and phosphorylates HSF-1.	BIND	9155018
IER3	DIF-2 \| DIF2 \| GLY96 \| IEX-1 \| IEX-1L \| IEX1 \| PRG1	immediate early response 3	Affinity Capture-Western	BioGRID	12356731
INSR	CD220 \| HHF5	insulin receptor	-	HPRD,BioGRID	11409918
IRX2	IRXA2	iroquois homeobox 2	IRX2 interacts with MAPK3 (Erk1). This interaction was modelled on a demonstrated interaction between chicken IRX2 and human MAPK3.	BIND	15133517
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	-	HPRD,BioGRID	1922387
KSR2	FLJ25965	kinase suppressor of ras 2	-	HPRD	12975377
LYN	FLJ26625 \| JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	-	HPRD,BioGRID	11131153
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	Affinity Capture-Western Biochemical Activity Co-localization Reconstituted Complex Two-hybrid	BioGRID	8226933 \|8626767 \|9006895 \|9733512 \|10748187
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	MEK1 interacts with ERK1 via a conserved docking site in MEK	BIND	11134045
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	-	HPRD	8226933 \|8626767 \|10748187
MAP2K2	FLJ26075 \| MAPKK2 \| MEK2 \| MKK2 \| PRKMK2	mitogen-activated protein kinase kinase 2	-	HPRD,BioGRID	8226933 \|8626767
MAP2K2	FLJ26075 \| MAPKK2 \| MEK2 \| MKK2 \| PRKMK2	mitogen-activated protein kinase kinase 2	MEK2 binds and activates ERK1.	BIND	11134045
MAP2K3	MAPKK3 \| MEK3 \| MKK3 \| PRKMK3	mitogen-activated protein kinase kinase 3	-	HPRD,BioGRID	8226933
MAP3K1	MAPKKK1 \| MEKK \| MEKK1	mitogen-activated protein kinase kinase kinase 1	MEKK1 interacts with ERK1.	BIND	12049732
MAPK14	CSBP1 \| CSBP2 \| CSPB1 \| EXIP \| Mxi2 \| PRKM14 \| PRKM15 \| RK \| SAPK2A \| p38 \| p38ALPHA	mitogen-activated protein kinase 14	-	HPRD,BioGRID	12697810
MAPKSP1	MAP2K1IP1 \| MAPBP \| MP1	MAPK scaffold protein 1	-	HPRD,BioGRID	9733512
MKNK1	MNK1	MAP kinase interacting serine/threonine kinase 1	ERK1 interacts with and phosphorylates MNK1.	BIND	9155018
MKNK1	MNK1	MAP kinase interacting serine/threonine kinase 1	Biochemical Activity	BioGRID	9155018
MYC	bHLHe39 \| c-Myc	v-myc myelocytomatosis viral oncogene homolog (avian)	Reconstituted Complex	BioGRID	15210690
MYC	bHLHe39 \| c-Myc	v-myc myelocytomatosis viral oncogene homolog (avian)	ERK1 interacts with and phosphorylates c-Myc.	BIND	9155018
MYLK	DKFZp686I10125 \| FLJ12216 \| KRP \| MLCK \| MLCK1 \| MLCK108 \| MLCK210 \| MSTP083 \| MYLK1 \| smMLCK	myosin light chain kinase	-	HPRD	10402467
PEA15	HMAT1 \| HUMMAT1H \| MAT1 \| MAT1H \| PEA-15 \| PED	phosphoprotein enriched in astrocytes 15	-	HPRD,BioGRID	11702783
PEA15	HMAT1 \| HUMMAT1H \| MAT1 \| MAT1H \| PEA-15 \| PED	phosphoprotein enriched in astrocytes 15	PEA-15 interacts with ERK 1.	BIND	11702783
PLAT	DKFZp686I03148 \| T-PA \| TPA	plasminogen activator, tissue	-	HPRD	15861134
PTPN5	FLJ14427 \| PTPSTEP \| STEP	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	-	HPRD,BioGRID	9857190
PTPN7	BPTP-4 \| HEPTP \| LC-PTP \| LPTP \| PTPNI	protein tyrosine phosphatase, non-receptor type 7	-	HPRD,BioGRID	10206983 \|10559944
PTPRR	DKFZp781C1038 \| EC-PTP \| FLJ34328 \| MGC131968 \| MGC148170 \| PCPTP1 \| PTP-SL \| PTPBR7 \| PTPRQ	protein tyrosine phosphatase, receptor type, R	-	HPRD,BioGRID	9857190
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	Affinity Capture-Western	BioGRID	11409918
RALGDS	FLJ20922 \| RGF \| RalGEF	ral guanine nucleotide dissociation stimulator	ERK1 interacts with and phosphorylates RalGDS.	BIND	9155018
RPS6KA1	HU-1 \| MAPKAPK1A \| RSK \| RSK1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	-	HPRD,BioGRID	12832467
RPS6KA2	HU-2 \| MAPKAPK1C \| RSK \| RSK3 \| S6K-alpha \| S6K-alpha2 \| p90-RSK3 \| pp90RSK3	ribosomal protein S6 kinase, 90kDa, polypeptide 2	-	HPRD,BioGRID	8939914
RPS6KA2	HU-2 \| MAPKAPK1C \| RSK \| RSK3 \| S6K-alpha \| S6K-alpha2 \| p90-RSK3 \| pp90RSK3	ribosomal protein S6 kinase, 90kDa, polypeptide 2	ERK1 interacts with and phosphorylates an unspecified isoform of p90-RSK2.	BIND	9155018
RPS6KA3	CLS \| HU-3 \| ISPK-1 \| MAPKAPK1B \| MRX19 \| RSK \| RSK2 \| S6K-alpha3 \| p90-RSK2 \| pp90RSK2	ribosomal protein S6 kinase, 90kDa, polypeptide 3	-	HPRD	12832467
RPS6KA3	CLS \| HU-3 \| ISPK-1 \| MAPKAPK1B \| MRX19 \| RSK \| RSK2 \| S6K-alpha3 \| p90-RSK2 \| pp90RSK2	ribosomal protein S6 kinase, 90kDa, polypeptide 3	Affinity Capture-Western	BioGRID	8939914
RPS6KA4	MSK2 \| RSK-B	ribosomal protein S6 kinase, 90kDa, polypeptide 4	-	HPRD,BioGRID	9792677
SNCA	MGC110988 \| NACP \| PARK1 \| PARK4 \| PD1	synuclein, alpha (non A4 component of amyloid precursor)	Affinity Capture-Western	BioGRID	12121974
SNCG	BCSG1 \| SR	synuclein, gamma (breast cancer-specific protein 1)	Affinity Capture-Western	BioGRID	12121974
SORBS3	SCAM-1 \| SCAM1 \| SH3D4 \| VINEXIN	sorbin and SH3 domain containing 3	-	HPRD	15184391
SPIB	SPI-B	Spi-B transcription factor (Spi-1/PU.1 related)	-	HPRD,BioGRID	8632909
SREBF1	SREBP-1c \| SREBP1 \| bHLHd1	sterol regulatory element binding transcription factor 1	Biochemical Activity	BioGRID	10627507
SREBF2	SREBP2 \| bHLHd2	sterol regulatory element binding transcription factor 2	-	HPRD,BioGRID	10627507
TAL2	bHLHa19	T-cell acute lymphocytic leukemia 2	-	HPRD	8152805
TH	TYH	tyrosine hydroxylase	-	HPRD,BioGRID	1347949
TNFSF11	CD254 \| ODF \| OPGL \| OPTB2 \| RANKL \| TRANCE \| hRANKL2 \| sOdf	tumor necrosis factor (ligand) superfamily, member 11	-	HPRD	10635328
TOP2B	TOPIIB \| top2beta	topoisomerase (DNA) II beta 180kDa	ERK1 interacts with and phosphorylates Topoisomerase II-beta.	BIND	9155018
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD,BioGRID	10958792
UBR5	DD5 \| EDD \| EDD1 \| FLJ11310 \| HYD \| KIAA0896 \| MGC57263	ubiquitin protein ligase E3 component n-recognin 5	Affinity Capture-Western	BioGRID	12594221
ZNF7	FLJ38706 \| HF.16 \| KOX4 \| zf30	zinc finger protein 7	ERK1 interacts with and phosphorylates ZNF7.	BIND	9155018

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY	87	71	All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY	190	128	All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG MTOR SIGNALING PATHWAY	52	40	All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION	115	81	All SZGR 2.0 genes in this pathway
KEGG DORSO VENTRAL AXIS FORMATION	25	21	All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY	86	64	All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE	129	103	All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY	76	53	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION	90	68	All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY	102	88	All SZGR 2.0 genes in this pathway
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY	62	47	All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY	137	92	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY	75	56	All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY	79	58	All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS	97	71	All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION	70	57	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION	70	53	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY	137	103	All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY	101	77	All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION	86	59	All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS	102	80	All SZGR 2.0 genes in this pathway
KEGG TYPE II DIABETES MELLITUS	47	41	All SZGR 2.0 genes in this pathway
KEGG ALDOSTERONE REGULATED SODIUM REABSORPTION	42	29	All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
KEGG PRION DISEASES	35	28	All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION	72	56	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER	62	47	All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA	70	60	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER	52	45	All SZGR 2.0 genes in this pathway
KEGG GLIOMA	65	56	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
KEGG THYROID CANCER	29	26	All SZGR 2.0 genes in this pathway
KEGG MELANOMA	71	57	All SZGR 2.0 genes in this pathway
KEGG BLADDER CANCER	42	33	All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA	73	59	All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA	60	47	All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER	54	47	All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY	36	31	All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY	36	28	All SZGR 2.0 genes in this pathway
BIOCARTA SPPA PATHWAY	22	18	All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY	37	28	All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY	45	35	All SZGR 2.0 genes in this pathway
BIOCARTA CDMAC PATHWAY	16	15	All SZGR 2.0 genes in this pathway
BIOCARTA CCR3 PATHWAY	23	21	All SZGR 2.0 genes in this pathway
BIOCARTA CERAMIDE PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA CXCR4 PATHWAY	24	22	All SZGR 2.0 genes in this pathway
BIOCARTA EGF PATHWAY	31	25	All SZGR 2.0 genes in this pathway
BIOCARTA EPO PATHWAY	19	13	All SZGR 2.0 genes in this pathway
BIOCARTA ECM PATHWAY	24	17	All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA FCER1 PATHWAY	41	30	All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY	39	29	All SZGR 2.0 genes in this pathway
BIOCARTA GH PATHWAY	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA MPR PATHWAY	34	28	All SZGR 2.0 genes in this pathway
BIOCARTA HCMV PATHWAY	17	16	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1 PATHWAY	21	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL2 PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL3 PATHWAY	15	11	All SZGR 2.0 genes in this pathway
BIOCARTA IL6 PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL2RB PATHWAY	38	26	All SZGR 2.0 genes in this pathway
BIOCARTA RACCYCD PATHWAY	26	23	All SZGR 2.0 genes in this pathway
BIOCARTA GLEEVEC PATHWAY	23	17	All SZGR 2.0 genes in this pathway
BIOCARTA INSULIN PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY	38	29	All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY	46	38	All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY	31	24	All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY	87	68	All SZGR 2.0 genes in this pathway
BIOCARTA MCALPAIN PATHWAY	25	16	All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1R PATHWAY	23	20	All SZGR 2.0 genes in this pathway
BIOCARTA NGF PATHWAY	18	13	All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY	56	45	All SZGR 2.0 genes in this pathway
BIOCARTA PDGF PATHWAY	32	25	All SZGR 2.0 genes in this pathway
BIOCARTA EDG1 PATHWAY	27	24	All SZGR 2.0 genes in this pathway
BIOCARTA CDK5 PATHWAY	11	11	All SZGR 2.0 genes in this pathway
BIOCARTA PTEN PATHWAY	18	14	All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY	23	20	All SZGR 2.0 genes in this pathway
BIOCARTA NKCELLS PATHWAY	20	13	All SZGR 2.0 genes in this pathway
BIOCARTA BAD PATHWAY	26	23	All SZGR 2.0 genes in this pathway
BIOCARTA EIF4 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
BIOCARTA DREAM PATHWAY	14	13	All SZGR 2.0 genes in this pathway
BIOCARTA HER2 PATHWAY	22	17	All SZGR 2.0 genes in this pathway
BIOCARTA ERK5 PATHWAY	18	15	All SZGR 2.0 genes in this pathway
BIOCARTA MAL PATHWAY	19	17	All SZGR 2.0 genes in this pathway
BIOCARTA BARR MAPK PATHWAY	12	11	All SZGR 2.0 genes in this pathway
BIOCARTA BARRESTIN SRC PATHWAY	15	14	All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY	37	30	All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY	37	31	All SZGR 2.0 genes in this pathway
BIOCARTA SPRY PATHWAY	18	15	All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY	49	37	All SZGR 2.0 genes in this pathway
BIOCARTA TGFB PATHWAY	19	14	All SZGR 2.0 genes in this pathway
BIOCARTA TPO PATHWAY	24	17	All SZGR 2.0 genes in this pathway
BIOCARTA CREB PATHWAY	27	25	All SZGR 2.0 genes in this pathway
BIOCARTA TFF PATHWAY	21	15	All SZGR 2.0 genes in this pathway
ST DIFFERENTIATION PATHWAY IN PC12 CELLS	45	35	All SZGR 2.0 genes in this pathway
SA B CELL RECEPTOR COMPLEXES	24	20	All SZGR 2.0 genes in this pathway
ST ERK1 ERK2 MAPK PATHWAY	32	25	All SZGR 2.0 genes in this pathway
SIG CD40PATHWAYMAP	34	28	All SZGR 2.0 genes in this pathway
SIG IL4RECEPTOR IN B LYPHOCYTES	27	23	All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	51	41	All SZGR 2.0 genes in this pathway
SIG BCR SIGNALING PATHWAY	46	38	All SZGR 2.0 genes in this pathway
SA PTEN PATHWAY	17	14	All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY	62	43	All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY	65	50	All SZGR 2.0 genes in this pathway
PID PRL SIGNALING EVENTS PATHWAY	23	17	All SZGR 2.0 genes in this pathway
PID ERBB4 PATHWAY	38	32	All SZGR 2.0 genes in this pathway
PID GMCSF PATHWAY	37	31	All SZGR 2.0 genes in this pathway
PID MET PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY	29	24	All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY	40	38	All SZGR 2.0 genes in this pathway
PID AVB3 OPN PATHWAY	31	29	All SZGR 2.0 genes in this pathway
PID S1P S1P4 PATHWAY	14	11	All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY	46	39	All SZGR 2.0 genes in this pathway
PID TRAIL PATHWAY	28	20	All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY	70	51	All SZGR 2.0 genes in this pathway
PID RET PATHWAY	39	29	All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY	50	41	All SZGR 2.0 genes in this pathway
PID S1P S1P1 PATHWAY	21	18	All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY	68	48	All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY	32	27	All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY	54	47	All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY	82	60	All SZGR 2.0 genes in this pathway
PID ARF6 DOWNSTREAM PATHWAY	15	14	All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY	69	55	All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY	55	43	All SZGR 2.0 genes in this pathway
PID ERBB1 RECEPTOR PROXIMAL PATHWAY	35	29	All SZGR 2.0 genes in this pathway
PID TCR RAS PATHWAY	14	14	All SZGR 2.0 genes in this pathway
PID CERAMIDE PATHWAY	48	37	All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY	75	53	All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY	40	34	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY	59	43	All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3 PATHWAY	44	35	All SZGR 2.0 genes in this pathway
PID ALK1 PATHWAY	26	21	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY	62	48	All SZGR 2.0 genes in this pathway
PID SYNDECAN 1 PATHWAY	46	29	All SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY	30	23	All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY	31	27	All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY	43	34	All SZGR 2.0 genes in this pathway
PID VEGFR1 PATHWAY	26	23	All SZGR 2.0 genes in this pathway
PID SMAD2 3PATHWAY	17	13	All SZGR 2.0 genes in this pathway
PID KIT PATHWAY	52	40	All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY	69	57	All SZGR 2.0 genes in this pathway
PID SYNDECAN 2 PATHWAY	33	27	All SZGR 2.0 genes in this pathway
PID ANTHRAX PATHWAY	17	15	All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
PID MAPK TRK PATHWAY	34	31	All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY	65	56	All SZGR 2.0 genes in this pathway
PID LYMPH ANGIOGENESIS PATHWAY	25	16	All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY	33	25	All SZGR 2.0 genes in this pathway
PID FGF PATHWAY	55	37	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME SPRY REGULATION OF FGF SIGNALING	14	9	All SZGR 2.0 genes in this pathway
REACTOME GROWTH HORMONE RECEPTOR SIGNALING	24	19	All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING	74	54	All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING	37	24	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4	90	67	All SZGR 2.0 genes in this pathway
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	66	45	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	22	20	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	20	17	All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	87	64	All SZGR 2.0 genes in this pathway
REACTOME ARMS MEDIATED ACTIVATION	17	17	All SZGR 2.0 genes in this pathway
REACTOME PROLONGED ERK ACTIVATION EVENTS	19	18	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO RAS	27	23	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS	36	30	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO P38 VIA RIT AND RIN	15	14	All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	205	136	All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	24	20	All SZGR 2.0 genes in this pathway
REACTOME ERKS ARE INACTIVATED	12	9	All SZGR 2.0 genes in this pathway
REACTOME SHC1 EVENTS IN EGFR SIGNALING	15	13	All SZGR 2.0 genes in this pathway
REACTOME ERK MAPK TARGETS	21	17	All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION	89	64	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION	210	127	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	64	49	All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE	36	27	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	50	37	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	10	8	All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	30	24	All SZGR 2.0 genes in this pathway
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION	122	80	All SZGR 2.0 genes in this pathway
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	32	20	All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS	86	62	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL TRANSDUCTION BY L1	34	25	All SZGR 2.0 genes in this pathway
REACTOME RNA POL I PROMOTER OPENING	62	49	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	77	57	All SZGR 2.0 genes in this pathway
REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	13	11	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING	159	116	All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	72	53	All SZGR 2.0 genes in this pathway
REACTOME IL 2 SIGNALING	41	34	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR	108	72	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL ATTENUATION	14	8	All SZGR 2.0 genes in this pathway
REACTOME SOS MEDIATED SIGNALLING	14	13	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME RAF MAP KINASE CASCADE	10	10	All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED SIGNALLING	15	12	All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	83	63	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
REACTOME SHC RELATED EVENTS	17	13	All SZGR 2.0 genes in this pathway
LIU CMYB TARGETS UP	165	106	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP	233	161	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP	157	104	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
MARTIN INTERACT WITH HDAC	44	31	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
LIAO METASTASIS	539	324	All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 8	36	28	All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT UP	165	100	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION	405	264	All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS POSTNATAL	63	50	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP	566	371	All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER PROGRESSION DN	21	16	All SZGR 2.0 genes in this pathway
TSUDA ALVEOLAR SOFT PART SARCOMA	10	7	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
KAPOSI LIVER CANCER MET UP	18	11	All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA DN	80	53	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN	146	90	All SZGR 2.0 genes in this pathway
ZHANG ADIPOGENESIS BY BMP7	14	12	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-15/16/195/424/497	388	394	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
				hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-205	108	114	1A	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-7	120	126	1A	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MAPK3