Gene Page: MAPK3

Summary
GeneID  5595
Symbol  MAPK3
Synonyms  ERK1|HS44KDAP|HUMKER1A|MGC20180|P44ERK1|P44MAPK|PRKM3
Description  mitogen-activated protein kinase 3
See related  HGNC:6877|MIM:601795|Ensembl:ENSG00000102882|HPRD:03479|
Locus tag  -
Gene type  protein-coding
Map location  16p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1437 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SLC16A120.740.59
RBM470.710.50
KCNJ130.700.31
CP0.680.11
SLC35F50.670.64
SLC5A50.670.21
SLC13A40.660.19
PRLR0.650.43
ABCA40.650.28
ANO60.650.68
Top 10 negatively co-expressed genes
AF347015.21-0.35-0.42
AC018755.7-0.34-0.48
MT-CO2-0.33-0.47
ENHO-0.33-0.47
MT1G-0.32-0.45
CXCL14-0.32-0.42
IFI27-0.32-0.44
AL022328.1-0.32-0.35
S100A13-0.32-0.42
AF347015.33-0.31-0.43
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004707MAP kinase activityEXP11741541 
GO:0004707MAP kinase activityIEA-
GO:0004707MAP kinase activityNAS7687743 
GO:0005515protein bindingIPI15950189 
GO:0005524ATP bindingIEA-
GO:0005524ATP bindingNAS-
GO:0004672protein kinase activityIEA-
GO:0004674protein serine/threonine kinase activityEXP16626623 
GO:0004674protein serine/threonine kinase activityIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIDA7687743 
GO:0006468protein amino acid phosphorylationIEA-
GO:0007265Ras protein signal transductionEXP11520933 
GO:0007049cell cycleIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP7739560 
GO:0005856cytoskeletonIDA18029348 
GO:0005575cellular_componentND-
GO:0005634nucleusIDA18029348 
GO:0005654nucleoplasmEXP9687510 |11741541 |16456541 
|16626623 |17322878 
GO:0005730nucleolusIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARRB2ARB2 | ARR2 | BARR2 | DKFZp686L0365arrestin, beta 2Affinity Capture-WesternBioGRID12473660 
ATF2CRE-BP1 | CREB2 | HB16 | MGC111558 | TREB7activating transcription factor 2ERK1 interacts with and phosphorylates ATF2.BIND9155018 
ATP1A1MGC3285 | MGC51750ATPase, Na+/K+ transporting, alpha 1 polypeptide-HPRD,BioGRID15069082 
AVPR2ADHR | DI1 | DIR | DIR3 | MGC126533 | MGC138386 | NDI | V2Rarginine vasopressin receptor 2Affinity Capture-WesternBioGRID12473660 
BCL3BCL4 | D19S37B-cell CLL/lymphoma 3Erk1 interacts with and phosphorylates BCL-3.BIND15469820 
BRAFB-RAF1 | BRAF1 | FLJ95109 | MGC126806 | MGC138284 | RAFB1v-raf murine sarcoma viral oncogene homolog B1Phenotypic EnhancementBioGRID10869359 
C1QBPGC1QBP | HABP1 | SF2p32 | gC1Q-R | gC1qR | p32complement component 1, q subcomponent binding protein-HPRD,BioGRID11866440 
CASP9APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6caspase 9, apoptosis-related cysteine peptidase-HPRD12792650 
DAPK1DAPK | DKFZp781I035death-associated protein kinase 1DAPK interacts with Erk1.BIND15616583 
DCCCRC18 | CRCR1deleted in colorectal carcinoma-HPRD,BioGRID11986622 
DUSP1CL100 | HVH1 | MKP-1 | MKP1 | PTPN10dual specificity phosphatase 1-HPRD,BioGRID11278799 
DUSP10MKP-5 | MKP5dual specificity phosphatase 10-HPRD10597297 
DUSP3VHRdual specificity phosphatase 3-HPRD,BioGRID10224087 
DUSP4HVH2 | MKP-2 | MKP2 | TYPdual specificity phosphatase 4Reconstituted ComplexBioGRID11387337 
-HPRD7535768 
DUSP5DUSP | HVH3dual specificity phosphatase 5-HPRD,BioGRID7836374 
DUSP6MKP3 | PYST1dual specificity phosphatase 6-HPRD,BioGRID9535927 
ELK1-ELK1, member of ETS oncogene familyElk-1 is phosphorylated by ERK-1. This interaction was modeled on a demonstrated interaction between human Elk-1 and ERK-1 from an unspecified species.BIND9130707 
-HPRD8208531 |12473660 
Mapk3 (p44Mapk) phosphorylates Elk1 at Ser383.BIND15782123 
ERK1 interacts with and phosphorylates Elk1. This interaction was modelled on a demonstrated interaction between rat ERK1 and human Elk1.BIND9235954 
Elk-1 is phosphorylated by ERK-1. This interaction was modeled on a demonstrated interaction between human Elk-1 and ERK-1 from an unspecified species.BIND9020136 
ERK1 interacts with and phosphorylates Elk-1.BIND9155018 
Erk1 phosphorylates Elk-1. This interaction was modeled on a demonstrated interaction between Erk1 and Elk-1 from an unspecified species.BIND10431817 
ELK4SAP1ELK4, ETS-domain protein (SRF accessory protein 1)Sap-1a is phosphorylated by ERK-1. This interaction was modeled on a demonstrated interaction between human Sap-1a and ERK-1 from an unspecified species.BIND9020136 
Sap-1a is phosphorylated by ERK-1. This interaction was modeled on a demonstrated interaction between human Sap-1a and ERK-1 from an unspecified species.BIND9130707 
EPORMGC138358erythropoietin receptor-HPRD12538595 
ETV1DKFZp781L0674 | ER81 | MGC104699 | MGC120533 | MGC120534ets variant 1Biochemical ActivityBioGRID11551945 
GATA4MGC126629GATA binding protein 4-HPRD11585926 
GMFBGMFglia maturation factor, beta-HPRD,BioGRID8639570 
GTF2IBAP-135 | BAP135 | BTKAP1 | DIWS | FLJ38776 | FLJ56355 | IB291 | SPIN | TFII-I | WBS | WBSCR6general transcription factor II, i-HPRD,BioGRID10648599 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4-HPRD,BioGRID11114188 
HIF1AHIF-1alpha | HIF1 | HIF1-ALPHA | MOP1 | PASD8hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)-HPRD10551817 
HMMRCD168 | IHABP | MGC119494 | MGC119495 | RHAMMhyaluronan-mediated motility receptor (RHAMM)-HPRD11403955 
HSF1HSTF1heat shock transcription factor 1ERK1 interacts with and phosphorylates HSF-1.BIND9155018 
IER3DIF-2 | DIF2 | GLY96 | IEX-1 | IEX-1L | IEX1 | PRG1immediate early response 3Affinity Capture-WesternBioGRID12356731 
INSRCD220 | HHF5insulin receptor-HPRD,BioGRID11409918 
IRX2IRXA2iroquois homeobox 2IRX2 interacts with MAPK3 (Erk1). This interaction was modelled on a demonstrated interaction between chicken IRX2 and human MAPK3.BIND15133517 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID1922387 
KSR2FLJ25965kinase suppressor of ras 2-HPRD12975377 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD,BioGRID11131153 
MAP2K1MAPKK1 | MEK1 | MKK1 | PRKMK1mitogen-activated protein kinase kinase 1Affinity Capture-Western
Biochemical Activity
Co-localization
Reconstituted Complex
Two-hybrid		BioGRID8226933 |8626767 
|9006895 |9733512 
|10748187 
MEK1 interacts with ERK1 via a conserved docking site in MEKBIND11134045 
-HPRD8226933 |8626767 
|10748187 
MAP2K2FLJ26075 | MAPKK2 | MEK2 | MKK2 | PRKMK2mitogen-activated protein kinase kinase 2-HPRD,BioGRID8226933 |8626767 
MEK2 binds and activates ERK1.BIND11134045 
MAP2K3MAPKK3 | MEK3 | MKK3 | PRKMK3mitogen-activated protein kinase kinase 3-HPRD,BioGRID8226933 
MAP3K1MAPKKK1 | MEKK | MEKK1mitogen-activated protein kinase kinase kinase 1MEKK1 interacts with ERK1.BIND12049732 
MAPK14CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHAmitogen-activated protein kinase 14-HPRD,BioGRID12697810 
MAPKSP1MAP2K1IP1 | MAPBP | MP1MAPK scaffold protein 1-HPRD,BioGRID9733512 
MKNK1MNK1MAP kinase interacting serine/threonine kinase 1ERK1 interacts with and phosphorylates MNK1.BIND9155018 
Biochemical ActivityBioGRID9155018 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Reconstituted ComplexBioGRID15210690 
ERK1 interacts with and phosphorylates c-Myc.BIND9155018 
MYLKDKFZp686I10125 | FLJ12216 | KRP | MLCK | MLCK1 | MLCK108 | MLCK210 | MSTP083 | MYLK1 | smMLCKmyosin light chain kinase-HPRD10402467 
PEA15HMAT1 | HUMMAT1H | MAT1 | MAT1H | PEA-15 | PEDphosphoprotein enriched in astrocytes 15-HPRD,BioGRID11702783 
PEA-15 interacts with ERK 1.BIND11702783 
PLATDKFZp686I03148 | T-PA | TPAplasminogen activator, tissue-HPRD15861134 
PTPN5FLJ14427 | PTPSTEP | STEPprotein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)-HPRD,BioGRID9857190 
PTPN7BPTP-4 | HEPTP | LC-PTP | LPTP | PTPNIprotein tyrosine phosphatase, non-receptor type 7-HPRD,BioGRID10206983 |10559944 
PTPRRDKFZp781C1038 | EC-PTP | FLJ34328 | MGC131968 | MGC148170 | PCPTP1 | PTP-SL | PTPBR7 | PTPRQprotein tyrosine phosphatase, receptor type, R-HPRD,BioGRID9857190 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1Affinity Capture-WesternBioGRID11409918 
RALGDSFLJ20922 | RGF | RalGEFral guanine nucleotide dissociation stimulatorERK1 interacts with and phosphorylates RalGDS.BIND9155018 
RPS6KA1HU-1 | MAPKAPK1A | RSK | RSK1ribosomal protein S6 kinase, 90kDa, polypeptide 1-HPRD,BioGRID12832467 
RPS6KA2HU-2 | MAPKAPK1C | RSK | RSK3 | S6K-alpha | S6K-alpha2 | p90-RSK3 | pp90RSK3ribosomal protein S6 kinase, 90kDa, polypeptide 2-HPRD,BioGRID8939914 
ERK1 interacts with and phosphorylates an unspecified isoform of p90-RSK2.BIND9155018 
RPS6KA3CLS | HU-3 | ISPK-1 | MAPKAPK1B | MRX19 | RSK | RSK2 | S6K-alpha3 | p90-RSK2 | pp90RSK2ribosomal protein S6 kinase, 90kDa, polypeptide 3-HPRD12832467 
Affinity Capture-WesternBioGRID8939914 
RPS6KA4MSK2 | RSK-Bribosomal protein S6 kinase, 90kDa, polypeptide 4-HPRD,BioGRID9792677 
SNCAMGC110988 | NACP | PARK1 | PARK4 | PD1synuclein, alpha (non A4 component of amyloid precursor)Affinity Capture-WesternBioGRID12121974 
SNCGBCSG1 | SRsynuclein, gamma (breast cancer-specific protein 1)Affinity Capture-WesternBioGRID12121974 
SORBS3SCAM-1 | SCAM1 | SH3D4 | VINEXINsorbin and SH3 domain containing 3-HPRD15184391 
SPIBSPI-BSpi-B transcription factor (Spi-1/PU.1 related)-HPRD,BioGRID8632909 
SREBF1SREBP-1c | SREBP1 | bHLHd1sterol regulatory element binding transcription factor 1Biochemical ActivityBioGRID10627507 
SREBF2SREBP2 | bHLHd2sterol regulatory element binding transcription factor 2-HPRD,BioGRID10627507 
TAL2bHLHa19T-cell acute lymphocytic leukemia 2-HPRD8152805 
THTYHtyrosine hydroxylase-HPRD,BioGRID1347949 
TNFSF11CD254 | ODF | OPGL | OPTB2 | RANKL | TRANCE | hRANKL2 | sOdftumor necrosis factor (ligand) superfamily, member 11-HPRD10635328 
TOP2BTOPIIB | top2betatopoisomerase (DNA) II beta 180kDaERK1 interacts with and phosphorylates Topoisomerase II-beta.BIND9155018 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID10958792 
UBR5DD5 | EDD | EDD1 | FLJ11310 | HYD | KIAA0896 | MGC57263ubiquitin protein ligase E3 component n-recognin 5Affinity Capture-WesternBioGRID12594221 
ZNF7FLJ38706 | HF.16 | KOX4 | zf30zinc finger protein 7ERK1 interacts with and phosphorylates ZNF7.BIND9155018 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
KEGG_MTOR_SIGNALING_PATHWAY 5240All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
KEGG_DORSO_VENTRAL_AXIS_FORMATION 2521All SZGR genes in this pathway
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY 7653All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 10288All SZGR genes in this pathway
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 6247All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 7556All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 7958All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 8659All SZGR genes in this pathway
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
KEGG_TYPE_II_DIABETES_MELLITUS 4741All SZGR genes in this pathway
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 4229All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_PRION_DISEASES 3528All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_COLORECTAL_CANCER 6247All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA 7060All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER 7056All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER 5245All SZGR genes in this pathway
KEGG_GLIOMA 6556All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_THYROID_CANCER 2926All SZGR genes in this pathway
KEGG_MELANOMA 7157All SZGR genes in this pathway
KEGG_BLADDER_CANCER 4233All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA 7359All SZGR genes in this pathway
KEGG_ACUTE_MYELOID_LEUKEMIA 6047All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER 5447All SZGR genes in this pathway
BIOCARTA_AGR_PATHWAY 3631All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY 3628All SZGR genes in this pathway
BIOCARTA_SPPA_PATHWAY 2218All SZGR genes in this pathway
BIOCARTA_BCR_PATHWAY 3728All SZGR genes in this pathway
BIOCARTA_BIOPEPTIDES_PATHWAY 4535All SZGR genes in this pathway
BIOCARTA_CDMAC_PATHWAY 1615All SZGR genes in this pathway
BIOCARTA_CCR3_PATHWAY 2321All SZGR genes in this pathway
BIOCARTA_CERAMIDE_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_CXCR4_PATHWAY 2422All SZGR genes in this pathway
BIOCARTA_EGF_PATHWAY 3125All SZGR genes in this pathway
BIOCARTA_EPO_PATHWAY 1913All SZGR genes in this pathway
BIOCARTA_ECM_PATHWAY 2417All SZGR genes in this pathway
BIOCARTA_ERK_PATHWAY 2822All SZGR genes in this pathway
BIOCARTA_FCER1_PATHWAY 4130All SZGR genes in this pathway
BIOCARTA_FMLP_PATHWAY 3929All SZGR genes in this pathway
BIOCARTA_GH_PATHWAY 2822All SZGR genes in this pathway
BIOCARTA_MPR_PATHWAY 3428All SZGR genes in this pathway
BIOCARTA_HCMV_PATHWAY 1716All SZGR genes in this pathway
BIOCARTA_IGF1_PATHWAY 2116All SZGR genes in this pathway
BIOCARTA_IL2_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_IL3_PATHWAY 1511All SZGR genes in this pathway
BIOCARTA_IL6_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_IL2RB_PATHWAY 3826All SZGR genes in this pathway
BIOCARTA_RACCYCD_PATHWAY 2623All SZGR genes in this pathway
BIOCARTA_GLEEVEC_PATHWAY 2317All SZGR genes in this pathway
BIOCARTA_INSULIN_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_INTEGRIN_PATHWAY 3829All SZGR genes in this pathway
BIOCARTA_KERATINOCYTE_PATHWAY 4638All SZGR genes in this pathway
BIOCARTA_PYK2_PATHWAY 3124All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
BIOCARTA_MCALPAIN_PATHWAY 2516All SZGR genes in this pathway
BIOCARTA_PPARA_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_IGF1R_PATHWAY 2320All SZGR genes in this pathway
BIOCARTA_NGF_PATHWAY 1813All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
BIOCARTA_PDGF_PATHWAY 3225All SZGR genes in this pathway
BIOCARTA_EDG1_PATHWAY 2724All SZGR genes in this pathway
BIOCARTA_CDK5_PATHWAY 1111All SZGR genes in this pathway
BIOCARTA_PTEN_PATHWAY 1814All SZGR genes in this pathway
BIOCARTA_RAS_PATHWAY 2320All SZGR genes in this pathway
BIOCARTA_NKCELLS_PATHWAY 2013All SZGR genes in this pathway
BIOCARTA_BAD_PATHWAY 2623All SZGR genes in this pathway
BIOCARTA_EIF4_PATHWAY 2419All SZGR genes in this pathway
BIOCARTA_DREAM_PATHWAY 1413All SZGR genes in this pathway
BIOCARTA_HER2_PATHWAY 2217All SZGR genes in this pathway
BIOCARTA_ERK5_PATHWAY 1815All SZGR genes in this pathway
BIOCARTA_MAL_PATHWAY 1917All SZGR genes in this pathway
BIOCARTA_BARR_MAPK_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_BARRESTIN_SRC_PATHWAY 1514All SZGR genes in this pathway
BIOCARTA_MET_PATHWAY 3730All SZGR genes in this pathway
BIOCARTA_GPCR_PATHWAY 3731All SZGR genes in this pathway
BIOCARTA_SPRY_PATHWAY 1815All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY 4937All SZGR genes in this pathway
BIOCARTA_TGFB_PATHWAY 1914All SZGR genes in this pathway
BIOCARTA_TPO_PATHWAY 2417All SZGR genes in this pathway
BIOCARTA_CREB_PATHWAY 2725All SZGR genes in this pathway
BIOCARTA_TFF_PATHWAY 2115All SZGR genes in this pathway
ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 4535All SZGR genes in this pathway
SA_B_CELL_RECEPTOR_COMPLEXES 2420All SZGR genes in this pathway
ST_ERK1_ERK2_MAPK_PATHWAY 3225All SZGR genes in this pathway
SIG_CD40PATHWAYMAP 3428All SZGR genes in this pathway
SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 2723All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 5141All SZGR genes in this pathway
SIG_BCR_SIGNALING_PATHWAY 4638All SZGR genes in this pathway
SA_PTEN_PATHWAY 1714All SZGR genes in this pathway
PID_FCER1_PATHWAY 6243All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY 6352All SZGR genes in this pathway
PID_BCR_5PATHWAY 6550All SZGR genes in this pathway
PID_PRL_SIGNALING_EVENTS_PATHWAY 2317All SZGR genes in this pathway
PID_ERBB4_PATHWAY 3832All SZGR genes in this pathway
PID_GMCSF_PATHWAY 3731All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_S1P_S1P3_PATHWAY 2924All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY 4038All SZGR genes in this pathway
PID_AVB3_OPN_PATHWAY 3129All SZGR genes in this pathway
PID_S1P_S1P4_PATHWAY 1411All SZGR genes in this pathway
PID_PS1_PATHWAY 4639All SZGR genes in this pathway
PID_TRAIL_PATHWAY 2820All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_RET_PATHWAY 3929All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_S1P_S1P1_PATHWAY 2118All SZGR genes in this pathway
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
PID_NETRIN_PATHWAY 3227All SZGR genes in this pathway
PID_NFAT_3PATHWAY 5447All SZGR genes in this pathway
PID_REG_GR_PATHWAY 8260All SZGR genes in this pathway
PID_ARF6_DOWNSTREAM_PATHWAY 1514All SZGR genes in this pathway
PID_MTOR_4PATHWAY 6955All SZGR genes in this pathway
PID_IL2_1PATHWAY 5543All SZGR genes in this pathway
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 3529All SZGR genes in this pathway
PID_TCR_RAS_PATHWAY 1414All SZGR genes in this pathway
PID_CERAMIDE_PATHWAY 4837All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
PID_IFNG_PATHWAY 4034All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_ATF2_PATHWAY 5943All SZGR genes in this pathway
PID_ERBB2_ERBB3_PATHWAY 4435All SZGR genes in this pathway
PID_ALK1_PATHWAY 2621All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_TRKR_PATHWAY 6248All SZGR genes in this pathway
PID_SYNDECAN_1_PATHWAY 4629All SZGR genes in this pathway
PID_RETINOIC_ACID_PATHWAY 3023All SZGR genes in this pathway
PID_AR_NONGENOMIC_PATHWAY 3127All SZGR genes in this pathway
PID_CXCR3_PATHWAY 4334All SZGR genes in this pathway
PID_VEGFR1_PATHWAY 2623All SZGR genes in this pathway
PID_SMAD2_3PATHWAY 1713All SZGR genes in this pathway
PID_KIT_PATHWAY 5240All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
PID_SYNDECAN_2_PATHWAY 3327All SZGR genes in this pathway
PID_ANTHRAX_PATHWAY 1715All SZGR genes in this pathway
PID_S1P_S1P2_PATHWAY 2419All SZGR genes in this pathway
PID_MAPK_TRK_PATHWAY 3431All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY 6556All SZGR genes in this pathway
PID_LYMPH_ANGIOGENESIS_PATHWAY 2516All SZGR genes in this pathway
PID_ALPHA_SYNUCLEIN_PATHWAY 3325All SZGR genes in this pathway
PID_FGF_PATHWAY 5537All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_SIGNALING_BY_SCF_KIT 7859All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING 149All SZGR genes in this pathway
REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING 2419All SZGR genes in this pathway
REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 7454All SZGR genes in this pathway
REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 3724All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 6645All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING 2220All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER 10980All SZGR genes in this pathway
REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING 2017All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_ARMS_MEDIATED_ACTIVATION 1717All SZGR genes in this pathway
REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS 1918All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_RAS 2723All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_ERKS 3630All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN 1514All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION 2420All SZGR genes in this pathway
REACTOME_ERKS_ARE_INACTIVATED 129All SZGR genes in this pathway
REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING 1513All SZGR genes in this pathway
REACTOME_ERK_MAPK_TARGETS 2117All SZGR genes in this pathway
REACTOME_RNA_POL_I_TRANSCRIPTION 8964All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
REACTOME_TRANSCRIPTION 210127All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 6449All SZGR genes in this pathway
REACTOME_FRS2_MEDIATED_CASCADE 3627All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 10074All SZGR genes in this pathway
REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 5037All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS 108All SZGR genes in this pathway
REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES 3024All SZGR genes in this pathway
REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 12280All SZGR genes in this pathway
REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 3220All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS 8662All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_SIGNAL_TRANSDUCTION_BY_L1 3425All SZGR genes in this pathway
REACTOME_RNA_POL_I_PROMOTER_OPENING 6249All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 7757All SZGR genes in this pathway
REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING 1311All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING 159116All SZGR genes in this pathway
REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 7253All SZGR genes in this pathway
REACTOME_IL_2_SIGNALING 4134All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_SIGNAL_ATTENUATION 148All SZGR genes in this pathway
REACTOME_SOS_MEDIATED_SIGNALLING 1413All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_RAF_MAP_KINASE_CASCADE 1010All SZGR genes in this pathway
REACTOME_SHC_MEDIATED_SIGNALLING 1512All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
REACTOME_SHC_RELATED_EVENTS 1713All SZGR genes in this pathway
LIU_CMYB_TARGETS_UP 165106All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP 157104All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
MARTIN_INTERACT_WITH_HDAC 4431All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_8 3628All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_UP 165100All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
MODY_HIPPOCAMPUS_POSTNATAL 6350All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_PROGRESSION_DN 2116All SZGR genes in this pathway
TSUDA_ALVEOLAR_SOFT_PART_SARCOMA 107All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
KAPOSI_LIVER_CANCER_MET_UP 1811All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_DN 8053All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_ALL_DISORDERS_DURATION_CORR_DN 14690All SZGR genes in this pathway
ZHANG_ADIPOGENESIS_BY_BMP7 1412All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-15/16/195/424/497388394m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-2051081141Ahsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-71201261Ahsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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