SZGR2

Summary ?

GeneID	5738
Symbol	PTGFRN
Synonyms	CD315\|CD9P-1\|EWI-F\|FPRP\|SMAP-6
Description	prostaglandin F2 receptor inhibitor
Reference	MIM:601204\|HGNC:HGNC:9601\|Ensembl:ENSG00000134247\|HPRD:03124\|Vega:OTTHUMG00000012028
Gene type	protein-coding
Map location	1p13.1
Pascal p-value	0.171
Sherlock p-value	0.81
DMG	1 (# studies)
eGene	Cerebellum Myers' cis & trans
Support	Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.0235
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.00814
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg14027204	1	117529478	PTGFRN	4.039E-4	0.267	0.044	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs5765916	chr22	45099825	PTGFRN	5738		0.03		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
TP53BP1	0.93	0.95
KIF3C	0.93	0.94
POLR3A	0.93	0.94
ACVR1B	0.92	0.95
PIP5K2B	0.92	0.94
SRGAP2P2	0.92	0.95
JAKMIP2	0.92	0.94
CAMSAP1	0.92	0.95
AOF1	0.92	0.95
CSNK2A1	0.92	0.93

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.77	-0.88
MT-CO2	-0.76	-0.87
FXYD1	-0.75	-0.85
AF347015.27	-0.74	-0.84
HSD17B14	-0.74	-0.79
HIGD1B	-0.73	-0.85
AF347015.33	-0.73	-0.82
MT-CYB	-0.73	-0.83
TSC22D4	-0.73	-0.79
S100B	-0.72	-0.81

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		11278880
GO:0005515	protein binding	ISS		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005794	Golgi apparatus	IEA		-
GO:0005789	endoplasmic reticulum membrane	IEA		-
GO:0005783	endoplasmic reticulum	IEA		-
GO:0016020	membrane	IEA		-
GO:0016021	integral to membrane	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
WINTER HYPOXIA UP	92	57	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP	306	188	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN	536	332	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
LIAO METASTASIS	539	324	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN	382	224	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
SUNG METASTASIS STROMA UP	110	70	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP	280	183	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP	566	371	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3	720	440	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5	482	296	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA RADIATION	81	59	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP	226	164	All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP	578	341	All SZGR 2.0 genes in this pathway
ENGELMANN CANCER PROGENITORS DN	70	44	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3	349	234	All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3	210	148	All SZGR 2.0 genes in this pathway
NIELSEN SCHWANNOMA DN	18	9	All SZGR 2.0 genes in this pathway
CHANGOLKAR H2AFY TARGETS UP	48	28	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4	227	149	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	738	744	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-130/301	2586	2592	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-137	3042	3049	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-137	3042	3049	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-144	3317	3323	m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-146	3132	3138	m8	hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
miR-146	3132	3138	m8	hsa-miR-146b^brain	UGAGAACUGAAUUCCAUAGGCU
miR-153	3336	3342	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d	200	206	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-18	717	724	1A,m8	hsa-miR-18a	UAAGGUGCAUCUAGUGCAGAUA
				hsa-miR-18b	UAAGGUGCAUCUAGUGCAGUUA
				hsa-miR-18a	UAAGGUGCAUCUAGUGCAGAUA
				hsa-miR-18b	UAAGGUGCAUCUAGUGCAGUUA
miR-30-5p	2720	2727	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
				hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-33	3340	3346	m8	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	3340	3346	m8	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-330	2962	2968	m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-448	3336	3342	1A	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-9	3011	3017	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PTGFRN