Gene Page: TMEM8A
Summary ?
| GeneID | 58986 |
| Symbol | TMEM8A |
| Synonyms | M83|TMEM6|TMEM8 |
| Description | transmembrane protein 8A |
| Reference | HGNC:HGNC:17205|Ensembl:ENSG00000129925|HPRD:11636|Vega:OTTHUMG00000047996 |
| Gene type | protein-coding |
| Map location | 16p13.3 |
| Pascal p-value | 0.011 |
| Sherlock p-value | 0.308 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs9876344 | chr3 | 77305890 | TMEM8A | 58986 | 0.16 | trans | ||
| rs8046256 | 16 | 393948 | TMEM8A | ENSG00000129925.6 | 2.536E-6 | 0.05 | 43165 | gtex_brain_ba24 |
| rs111865994 | 16 | 394446 | TMEM8A | ENSG00000129925.6 | 2.583E-6 | 0.05 | 42667 | gtex_brain_ba24 |
| rs12928797 | 16 | 403289 | TMEM8A | ENSG00000129925.6 | 2.569E-6 | 0.05 | 33824 | gtex_brain_ba24 |
| rs8064205 | 16 | 369413 | TMEM8A | ENSG00000129925.6 | 1.115E-6 | 0 | 67700 | gtex_brain_putamen_basal |
| rs57401795 | 16 | 379526 | TMEM8A | ENSG00000129925.6 | 1.083E-6 | 0 | 57587 | gtex_brain_putamen_basal |
| rs10903015 | 16 | 380425 | TMEM8A | ENSG00000129925.6 | 1.557E-6 | 0 | 56688 | gtex_brain_putamen_basal |
| rs7206286 | 16 | 386179 | TMEM8A | ENSG00000129925.6 | 1.939E-6 | 0 | 50934 | gtex_brain_putamen_basal |
| rs2361989 | 16 | 390780 | TMEM8A | ENSG00000129925.6 | 9.585E-7 | 0 | 46333 | gtex_brain_putamen_basal |
| rs3743883 | 16 | 404750 | TMEM8A | ENSG00000129925.6 | 2.204E-6 | 0 | 32363 | gtex_brain_putamen_basal |
| rs11860497 | 16 | 405416 | TMEM8A | ENSG00000129925.6 | 1.67E-6 | 0 | 31697 | gtex_brain_putamen_basal |
| rs28687790 | 16 | 412984 | TMEM8A | ENSG00000129925.6 | 1.952E-7 | 0 | 24129 | gtex_brain_putamen_basal |
| rs7187875 | 16 | 413747 | TMEM8A | ENSG00000129925.6 | 1.609E-7 | 0 | 23366 | gtex_brain_putamen_basal |
| rs12925248 | 16 | 414374 | TMEM8A | ENSG00000129925.6 | 1.402E-7 | 0 | 22739 | gtex_brain_putamen_basal |
| rs3848368 | 16 | 414608 | TMEM8A | ENSG00000129925.6 | 1.372E-7 | 0 | 22505 | gtex_brain_putamen_basal |
| rs3073802 | 16 | 415460 | TMEM8A | ENSG00000129925.6 | 1.211E-7 | 0 | 21653 | gtex_brain_putamen_basal |
| rs12928836 | 16 | 416663 | TMEM8A | ENSG00000129925.6 | 6.375E-8 | 0 | 20450 | gtex_brain_putamen_basal |
| rs11640313 | 16 | 418462 | TMEM8A | ENSG00000129925.6 | 1.536E-7 | 0 | 18651 | gtex_brain_putamen_basal |
| rs3830160 | 16 | 419092 | TMEM8A | ENSG00000129925.6 | 1.345E-9 | 0 | 18021 | gtex_brain_putamen_basal |
| rs3743884 | 16 | 420678 | TMEM8A | ENSG00000129925.6 | 4.173E-9 | 0 | 16435 | gtex_brain_putamen_basal |
| rs1984409 | 16 | 420723 | TMEM8A | ENSG00000129925.6 | 1.461E-8 | 0 | 16390 | gtex_brain_putamen_basal |
| rs540 | 16 | 420907 | TMEM8A | ENSG00000129925.6 | 6.857E-9 | 0 | 16206 | gtex_brain_putamen_basal |
| rs1573732 | 16 | 423420 | TMEM8A | ENSG00000129925.6 | 1.134E-7 | 0 | 13693 | gtex_brain_putamen_basal |
| rs5020353 | 16 | 423423 | TMEM8A | ENSG00000129925.6 | 1.134E-7 | 0 | 13690 | gtex_brain_putamen_basal |
| rs1573733 | 16 | 423555 | TMEM8A | ENSG00000129925.6 | 1.14E-7 | 0 | 13558 | gtex_brain_putamen_basal |
| rs1573734 | 16 | 423619 | TMEM8A | ENSG00000129925.6 | 1.144E-7 | 0 | 13494 | gtex_brain_putamen_basal |
| rs1573735 | 16 | 423696 | TMEM8A | ENSG00000129925.6 | 1.151E-7 | 0 | 13417 | gtex_brain_putamen_basal |
| rs3929996 | 16 | 423750 | TMEM8A | ENSG00000129925.6 | 1.701E-7 | 0 | 13363 | gtex_brain_putamen_basal |
| rs28461437 | 16 | 423813 | TMEM8A | ENSG00000129925.6 | 1.749E-8 | 0 | 13300 | gtex_brain_putamen_basal |
| rs11640037 | 16 | 423842 | TMEM8A | ENSG00000129925.6 | 3.747E-7 | 0 | 13271 | gtex_brain_putamen_basal |
| rs11643307 | 16 | 423843 | TMEM8A | ENSG00000129925.6 | 3.744E-7 | 0 | 13270 | gtex_brain_putamen_basal |
| rs3743888 | 16 | 424420 | TMEM8A | ENSG00000129925.6 | 1.654E-7 | 0 | 12693 | gtex_brain_putamen_basal |
| rs11646097 | 16 | 425605 | TMEM8A | ENSG00000129925.6 | 5.88E-8 | 0 | 11508 | gtex_brain_putamen_basal |
| rs2071915 | 16 | 426432 | TMEM8A | ENSG00000129925.6 | 9.148E-7 | 0 | 10681 | gtex_brain_putamen_basal |
| rs2071916 | 16 | 426476 | TMEM8A | ENSG00000129925.6 | 9.183E-7 | 0 | 10637 | gtex_brain_putamen_basal |
| rs763141 | 16 | 427309 | TMEM8A | ENSG00000129925.6 | 1.017E-6 | 0 | 9804 | gtex_brain_putamen_basal |
| rs763142 | 16 | 427349 | TMEM8A | ENSG00000129925.6 | 2.111E-6 | 0 | 9764 | gtex_brain_putamen_basal |
| rs11248931 | 16 | 427479 | TMEM8A | ENSG00000129925.6 | 1.039E-6 | 0 | 9634 | gtex_brain_putamen_basal |
| rs11649031 | 16 | 427516 | TMEM8A | ENSG00000129925.6 | 1.04E-6 | 0 | 9597 | gtex_brain_putamen_basal |
| rs11641693 | 16 | 427657 | TMEM8A | ENSG00000129925.6 | 1.062E-6 | 0 | 9456 | gtex_brain_putamen_basal |
| rs11641742 | 16 | 427784 | TMEM8A | ENSG00000129925.6 | 1.08E-6 | 0 | 9329 | gtex_brain_putamen_basal |
| rs12922073 | 16 | 427820 | TMEM8A | ENSG00000129925.6 | 1.087E-6 | 0 | 9293 | gtex_brain_putamen_basal |
| rs12933709 | 16 | 427866 | TMEM8A | ENSG00000129925.6 | 1.096E-6 | 0 | 9247 | gtex_brain_putamen_basal |
| rs61261356 | 16 | 427925 | TMEM8A | ENSG00000129925.6 | 1.107E-6 | 0 | 9188 | gtex_brain_putamen_basal |
| rs56990244 | 16 | 427999 | TMEM8A | ENSG00000129925.6 | 1.194E-7 | 0 | 9114 | gtex_brain_putamen_basal |
| rs59253482 | 16 | 428001 | TMEM8A | ENSG00000129925.6 | 1.124E-6 | 0 | 9112 | gtex_brain_putamen_basal |
| rs8058883 | 16 | 429059 | TMEM8A | ENSG00000129925.6 | 1.597E-6 | 0 | 8054 | gtex_brain_putamen_basal |
| rs763144 | 16 | 429951 | TMEM8A | ENSG00000129925.6 | 2.178E-6 | 0 | 7162 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC1 AND HDAC2 TARGETS UP | 238 | 144 | All SZGR 2.0 genes in this pathway |
| GOZGIT ESR1 TARGETS DN | 781 | 465 | All SZGR 2.0 genes in this pathway |
| AMIT EGF RESPONSE 480 HELA | 164 | 118 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 16P13 AMPLICON | 120 | 49 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT UP | 390 | 242 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| IWANAGA CARCINOGENESIS BY KRAS PTEN DN | 353 | 226 | All SZGR 2.0 genes in this pathway |
| MCCABE BOUND BY HOXC6 | 469 | 239 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 HCP WITH H3K27ME3 | 435 | 318 | All SZGR 2.0 genes in this pathway |
| WANG METASTASIS OF BREAST CANCER ESR1 UP | 22 | 14 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| CHYLA CBFA2T3 TARGETS DN | 242 | 146 | All SZGR 2.0 genes in this pathway |
| TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP | 271 | 165 | All SZGR 2.0 genes in this pathway |
| PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 | 403 | 240 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 | 227 | 149 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY LUMINAL MATURE UP | 116 | 65 | All SZGR 2.0 genes in this pathway |