SZGR2

Summary ?

GeneID	5901
Symbol	RAN
Synonyms	ARA24\|Gsp1\|TC4
Description	RAN, member RAS oncogene family
Reference	MIM:601179\|HGNC:HGNC:9846\|Ensembl:ENSG00000132341\|HPRD:03109\|Vega:OTTHUMG00000134328
Gene type	protein-coding
Map location	12q24.3
Pascal p-value	0.424
Sherlock p-value	0.807
Fetal beta	0.208
eGene	Myers' cis & trans
Support	G2Cdb.humanNRC G2Cdb.humanPSP

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0519

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs7132043	chr12	80968399	RAN	5901		0.18		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
KNTC1	0.95	0.85
PLK4	0.95	0.83
BRCA2	0.95	0.75
HELLS	0.94	0.74
SMC4	0.94	0.87
MCM8	0.94	0.81
C6orf167	0.94	0.85
FANCI	0.94	0.69
CENPI	0.94	0.79
TIMELESS	0.94	0.86

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
C5orf53	-0.52	-0.71
PTH1R	-0.52	-0.70
FBXO2	-0.51	-0.64
HLA-F	-0.51	-0.68
AF347015.31	-0.50	-0.77
CA4	-0.50	-0.72
IFI27	-0.50	-0.80
TNFSF12	-0.49	-0.65
AF347015.27	-0.49	-0.74
MT-CO2	-0.49	-0.78

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0003682	chromatin binding	TAS		1961752
GO:0003713	transcription coactivator activity	NAS		15572661
GO:0003924	GTPase activity	EXP		7878053
GO:0003924	GTPase activity	TAS		10400640
GO:0005515	protein binding	IPI		1961752
GO:0005525	GTP binding	IDA		1961752
GO:0050681	androgen receptor binding	NAS		15572661
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006405	RNA export from nucleus	NAS		-
GO:0006259	DNA metabolic process	TAS		8421051
GO:0007165	signal transduction	TAS		7603572
GO:0007067	mitosis	TAS		8421051
GO:0007052	mitotic spindle organization	TAS		10408446
GO:0007264	small GTPase mediated signal transduction	IEA		-
GO:0006913	nucleocytoplasmic transport	IEA		-
GO:0006611	protein export from nucleus	NAS		-
GO:0006886	intracellular protein transport	IEA		-
GO:0030521	androgen receptor signaling pathway	NAS		15572661
GO:0045893	positive regulation of transcription, DNA-dependent	NAS		15572661
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000785	chromatin	IDA		1961752
GO:0005829	cytosol	EXP		7878053
GO:0005634	nucleus	IEA		-
GO:0005643	nuclear pore	NAS		8421051
GO:0005654	nucleoplasm	EXP		9405152 \|9837918
GO:0005737	cytoplasm	IDA		1961752
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	-	HPRD,BioGRID	11420673
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD,BioGRID	10400640
ASAP2	AMAP2 \| CENTB3 \| DDEF2 \| FLJ42910 \| KIAA0400 \| PAG3 \| PAP \| Pap-alpha \| SHAG1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	-	HPRD	10022920
BMPR1B	ALK-6 \| ALK6 \| CDw293	bone morphogenetic protein receptor, type IB	BMPR1B interacts with RAN. This interaction was modeled on a demonstrated interaction between human BMPR1B and mouse RAN.	BIND	15761153
CSE1L	CAS \| CSE1 \| MGC117283 \| MGC130036 \| MGC130037 \| XPO2	CSE1 chromosome segregation 1-like (yeast)	-	HPRD	9323134
IPO11	RanBP11	importin 11	-	HPRD	11809816
IPO5	DKFZp686O1576 \| FLJ43041 \| IMB3 \| KPNB3 \| MGC2068 \| RANBP5	importin 5	-	HPRD,BioGRID	9114010
IPO7	FLJ14581 \| Imp7 \| MGC138673 \| RANBP7	importin 7	-	HPRD	9214382
KIAA1377	-	KIAA1377	Two-hybrid	BioGRID	16169070
KPNB1	IMB1 \| IPOB \| Impnb \| MGC2155 \| MGC2156 \| MGC2157 \| NTF97	karyopherin (importin) beta 1	Far Western Reconstituted Complex	BioGRID	9102465 \|9135132 \|10779340
KPNB1	IMB1 \| IPOB \| Impnb \| MGC2155 \| MGC2156 \| MGC2157 \| NTF97	karyopherin (importin) beta 1	-	HPRD	8576188 \|9135132
KPNB1	IMB1 \| IPOB \| Impnb \| MGC2155 \| MGC2156 \| MGC2157 \| NTF97	karyopherin (importin) beta 1	Interaction between KPNB1 (PDB ID: 1IBR_B) and RAN (PDB ID: 1IBR_A).	BIND	7615630 \|7627554 \|8896452 \|10367892
NEK9	DKFZp434D0935 \| MGC138306 \| MGC16714 \| NERCC \| NERCC1 \| Nek8	NIMA (never in mitosis gene a)- related kinase 9	-	HPRD,BioGRID	12101123
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	Two-hybrid	BioGRID	10508170
NUP153	HNUP153 \| N153	nucleoporin 153kDa	Reconstituted Complex	BioGRID	10202161
NUP50	MGC39961 \| NPAP60 \| NPAP60L	nucleoporin 50kDa	-	HPRD	12176322
NUTF2	NTF2 \| PP15	nuclear transport factor 2	-	HPRD	8757804 \|9368653 \|9533885 \|9822603 \|10679025
NUTF2	NTF2 \| PP15	nuclear transport factor 2	Co-crystal Structure Reconstituted Complex	BioGRID	9533885 \|15522285
PTMA	MGC104802 \| TMSA	prothymosin, alpha	-	HPRD	11310559
RANBP1	HTF9A \| MGC88701	RAN binding protein 1	-	HPRD,BioGRID	7891706 \|10779340
RANBP10	FLJ31165 \| KIAA1464	RAN binding protein 10	-	HPRD,BioGRID	14684163
RANBP2	NUP358 \| TRP1 \| TRP2	RAN binding protein 2	-	HPRD,BioGRID	10318915
RANBP3	DKFZp586I1520	RAN binding protein 3	-	HPRD,BioGRID	9637251
RANBP9	RANBPM	RAN binding protein 9	-	HPRD,BioGRID	9817760
RANGAP1	Fug1 \| KIAA1835 \| MGC20266 \| SD	Ran GTPase activating protein 1	-	HPRD,BioGRID	7744835 \|9219684 \|10394366
RANGRF	DKFZp686F02139 \| HSPC165 \| HSPC236 \| MGC110973 \| MOG1 \| RANGNRF	RAN guanine nucleotide release factor	-	HPRD,BioGRID	11290418
RCC1	CHC1 \| RCC1-I	regulator of chromosome condensation 1	Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	7891706 \|10369786 \|10811801 \|11336674
RCC1	CHC1 \| RCC1-I	regulator of chromosome condensation 1	-	HPRD	10369786 \|12194828
RGPD5	BS-63 \| DKFZp686I1842 \| RANBP2L1 \| RGP5	RANBP2-like and GRIP domain containing 5	-	HPRD	11774384
SMAD1	BSP1 \| JV4-1 \| JV41 \| MADH1 \| MADR1	SMAD family member 1	SMAD1 interacts with RAN. This interaction was modeled on a demonstrated interaction between human SMAD1 and mouse RAN.	BIND	15761153
SMARCB1	BAF47 \| INI1 \| RDT \| SNF5 \| SNF5L1 \| Sfh1p \| Snr1 \| hSNFS	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Reconstituted Complex	BioGRID	11782423
TGFBR1	AAT5 \| ACVRLK4 \| ALK-5 \| ALK5 \| LDS1A \| LDS2A \| SKR4 \| TGFR-1	transforming growth factor, beta receptor 1	TGF-beta-RI interacts with RAN. This interaction was modeled on a demonstrated interaction between human TGF-beta-RI and mouse RAN.	BIND	15761153
TNPO1	IPO2 \| KPNB2 \| MIP \| MIP1 \| TRN	transportin 1	-	HPRD,BioGRID	10353245
XPO1	CRM1 \| DKFZp686B1823	exportin 1 (CRM1 homolog, yeast)	-	HPRD,BioGRID	9323133
XPO5	FLJ14239 \| FLJ32057 \| FLJ45606 \| KIAA1291	exportin 5	-	HPRD,BioGRID	11777942
XPO6	EXP6 \| FLJ22519 \| KIAA0370 \| RANBP20	exportin 6	Affinity Capture-MS	BioGRID	14592989
XPOT	XPO3	exportin, tRNA (nuclear export receptor for tRNAs)	-	HPRD,BioGRID	9660920 \|12138183

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BIOCARTA RANMS PATHWAY	10	7	All SZGR 2.0 genes in this pathway
PID HDAC CLASSII PATHWAY	34	27	All SZGR 2.0 genes in this pathway
PID NFKAPPAB CANONICAL PATHWAY	23	20	All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY	66	50	All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY	54	47	All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY	49	43	All SZGR 2.0 genes in this pathway
PID RANBP2 PATHWAY	11	11	All SZGR 2.0 genes in this pathway
PID AURORA A PATHWAY	31	20	All SZGR 2.0 genes in this pathway
REACTOME MICRORNA MIRNA BIOGENESIS	23	9	All SZGR 2.0 genes in this pathway
REACTOME REGULATORY RNA PATHWAYS	26	12	All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA LIFE CYCLE	203	72	All SZGR 2.0 genes in this pathway
REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	27	19	All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION	207	122	All SZGR 2.0 genes in this pathway
REACTOME HIV LIFE CYCLE	125	69	All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS	132	81	All SZGR 2.0 genes in this pathway
REACTOME LATE PHASE OF HIV LIFE CYCLE	104	61	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA UP	92	57	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP	294	178	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN	431	263	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG DN	45	29	All SZGR 2.0 genes in this pathway
HWANG PROSTATE CANCER MARKERS	28	19	All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER	178	108	All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL	116	62	All SZGR 2.0 genes in this pathway
GRASEMANN RETINOBLASTOMA WITH 6P AMPLIFICATION	14	14	All SZGR 2.0 genes in this pathway
LUI TARGETS OF PAX8 PPARG FUSION	34	23	All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM	159	93	All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS AND SERUM RESPONSE DN	47	34	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP	167	92	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
SCIAN CELL CYCLE TARGETS OF TP53 AND TP73 DN	22	14	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN	81	51	All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE UP	80	54	All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE UP	86	49	All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE DN	90	55	All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN	85	56	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN	76	57	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI DN	73	45	All SZGR 2.0 genes in this pathway
MA MYELOID DIFFERENTIATION UP	39	29	All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI DN	172	107	All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP	81	52	All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN	141	99	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP	69	41	All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN	153	120	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN	215	132	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP	123	75	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE	77	50	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM	66	47	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST	132	93	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C	463	262	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
ALONSO METASTASIS EMT UP	36	24	All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP	198	128	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN	175	103	All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA	447	277	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP	163	102	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN	193	112	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14	143	86	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1	148	95	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A	182	108	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-151	27	33	m8	hsa-miR-151^brain	ACUAGACUGAAGCUCCUUGAGG
miR-181	156	162	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-324-5p	124	130	m8	hsa-miR-324-5p	CGCAUCCCCUAGGGCAUUGGUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: RAN