Gene Page: RAN

Summary
GeneID  5901
Symbol  RAN
Synonyms  ARA24|Gsp1|TC4
Description  RAN, member RAS oncogene family
See related  HGNC:9846|MIM:601179|Ensembl:ENSG00000132341|HPRD:03109|
Locus tag  -
Gene type  protein-coding
Map location  12q24.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0519 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KNTC10.950.85
PLK40.950.83
BRCA20.950.75
HELLS0.940.74
SMC40.940.87
MCM80.940.81
C6orf1670.940.85
FANCI0.940.69
CENPI0.940.79
TIMELESS0.940.86
Top 10 negatively co-expressed genes
C5orf53-0.52-0.71
PTH1R-0.52-0.70
FBXO2-0.51-0.64
HLA-F-0.51-0.68
AF347015.31-0.50-0.77
CA4-0.50-0.72
IFI27-0.50-0.80
TNFSF12-0.49-0.65
AF347015.27-0.49-0.74
MT-CO2-0.49-0.78
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003682chromatin bindingTAS1961752 
GO:0003713transcription coactivator activityNAS15572661 
GO:0003924GTPase activityEXP7878053 
GO:0003924GTPase activityTAS10400640 
GO:0005515protein bindingIPI1961752 
GO:0005525GTP bindingIDA1961752 
GO:0050681androgen receptor bindingNAS15572661 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006405RNA export from nucleusNAS-
GO:0006259DNA metabolic processTAS8421051 
GO:0007165signal transductionTAS7603572 
GO:0007067mitosisTAS8421051 
GO:0007052mitotic spindle organizationTAS10408446 
GO:0007264small GTPase mediated signal transductionIEA-
GO:0006913nucleocytoplasmic transportIEA-
GO:0006611protein export from nucleusNAS-
GO:0006886intracellular protein transportIEA-
GO:0030521androgen receptor signaling pathwayNAS15572661 
GO:0045893positive regulation of transcription, DNA-dependentNAS15572661 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000785chromatinIDA1961752 
GO:0005829cytosolEXP7878053 
GO:0005634nucleusIEA-
GO:0005643nuclear poreNAS8421051 
GO:0005654nucleoplasmEXP9405152 |9837918 
GO:0005737cytoplasmIDA1961752 
GO:0042470melanosomeIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID11420673 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID10400640 
ASAP2AMAP2 | CENTB3 | DDEF2 | FLJ42910 | KIAA0400 | PAG3 | PAP | Pap-alpha | SHAG1ArfGAP with SH3 domain, ankyrin repeat and PH domain 2-HPRD10022920 
BMPR1BALK-6 | ALK6 | CDw293bone morphogenetic protein receptor, type IBBMPR1B interacts with RAN. This interaction was modeled on a demonstrated interaction between human BMPR1B and mouse RAN.BIND15761153 
CSE1LCAS | CSE1 | MGC117283 | MGC130036 | MGC130037 | XPO2CSE1 chromosome segregation 1-like (yeast)-HPRD9323134 
IPO11RanBP11importin 11-HPRD11809816 
IPO5DKFZp686O1576 | FLJ43041 | IMB3 | KPNB3 | MGC2068 | RANBP5importin 5-HPRD,BioGRID9114010 
IPO7FLJ14581 | Imp7 | MGC138673 | RANBP7importin 7-HPRD9214382 
KIAA1377-KIAA1377Two-hybridBioGRID16169070 
KPNB1IMB1 | IPOB | Impnb | MGC2155 | MGC2156 | MGC2157 | NTF97karyopherin (importin) beta 1Far Western
Reconstituted Complex		BioGRID9102465 |9135132 
|10779340 
-HPRD8576188 |9135132 
Interaction between KPNB1 (PDB ID: 1IBR_B) and RAN (PDB ID: 1IBR_A).BIND7615630 |7627554 
|8896452 |10367892 
NEK9DKFZp434D0935 | MGC138306 | MGC16714 | NERCC | NERCC1 | Nek8NIMA (never in mitosis gene a)- related kinase 9-HPRD,BioGRID12101123 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)Two-hybridBioGRID10508170 
NUP153HNUP153 | N153nucleoporin 153kDaReconstituted ComplexBioGRID10202161 
NUP50MGC39961 | NPAP60 | NPAP60Lnucleoporin 50kDa-HPRD12176322 
NUTF2NTF2 | PP15nuclear transport factor 2-HPRD8757804 |9368653 
|9533885 |9822603 
|10679025 
Co-crystal Structure
Reconstituted Complex		BioGRID9533885 |15522285 
PTMAMGC104802 | TMSAprothymosin, alpha-HPRD11310559 
RANBP1HTF9A | MGC88701RAN binding protein 1-HPRD,BioGRID7891706 |10779340 
RANBP10FLJ31165 | KIAA1464RAN binding protein 10-HPRD,BioGRID14684163 
RANBP2NUP358 | TRP1 | TRP2RAN binding protein 2-HPRD,BioGRID10318915 
RANBP3DKFZp586I1520RAN binding protein 3-HPRD,BioGRID9637251 
RANBP9RANBPMRAN binding protein 9-HPRD,BioGRID9817760 
RANGAP1Fug1 | KIAA1835 | MGC20266 | SDRan GTPase activating protein 1-HPRD,BioGRID7744835 |9219684 
|10394366 
RANGRFDKFZp686F02139 | HSPC165 | HSPC236 | MGC110973 | MOG1 | RANGNRFRAN guanine nucleotide release factor-HPRD,BioGRID11290418 
RCC1CHC1 | RCC1-Iregulator of chromosome condensation 1Co-crystal Structure
Reconstituted Complex
Two-hybrid		BioGRID7891706 |10369786 
|10811801 |11336674 
-HPRD10369786 |12194828 
RGPD5BS-63 | DKFZp686I1842 | RANBP2L1 | RGP5RANBP2-like and GRIP domain containing 5-HPRD11774384 
SMAD1BSP1 | JV4-1 | JV41 | MADH1 | MADR1SMAD family member 1SMAD1 interacts with RAN. This interaction was modeled on a demonstrated interaction between human SMAD1 and mouse RAN.BIND15761153 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1Reconstituted ComplexBioGRID11782423 
TGFBR1AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1transforming growth factor, beta receptor 1TGF-beta-RI interacts with RAN. This interaction was modeled on a demonstrated interaction between human TGF-beta-RI and mouse RAN.BIND15761153 
TNPO1IPO2 | KPNB2 | MIP | MIP1 | TRNtransportin 1-HPRD,BioGRID10353245 
XPO1CRM1 | DKFZp686B1823exportin 1 (CRM1 homolog, yeast)-HPRD,BioGRID9323133 
XPO5FLJ14239 | FLJ32057 | FLJ45606 | KIAA1291exportin 5-HPRD,BioGRID11777942 
XPO6EXP6 | FLJ22519 | KIAA0370 | RANBP20exportin 6Affinity Capture-MSBioGRID14592989 
XPOTXPO3exportin, tRNA (nuclear export receptor for tRNAs)-HPRD,BioGRID9660920 |12138183 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_RANMS_PATHWAY 107All SZGR genes in this pathway
PID_HDAC_CLASSII_PATHWAY 3427All SZGR genes in this pathway
PID_NFKAPPAB_CANONICAL_PATHWAY 2320All SZGR genes in this pathway
PID_HDAC_CLASSI_PATHWAY 6650All SZGR genes in this pathway
PID_NFAT_3PATHWAY 5447All SZGR genes in this pathway
PID_FOXO_PATHWAY 4943All SZGR genes in this pathway
PID_RANBP2_PATHWAY 1111All SZGR genes in this pathway
PID_AURORA_A_PATHWAY 3120All SZGR genes in this pathway
REACTOME_MICRORNA_MIRNA_BIOGENESIS 239All SZGR genes in this pathway
REACTOME_REGULATORY_RNA_PATHWAYS 2612All SZGR genes in this pathway
REACTOME_INFLUENZA_LIFE_CYCLE 20372All SZGR genes in this pathway
REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY 2719All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HIV_LIFE_CYCLE 12569All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 10461All SZGR genes in this pathway
WINTER_HYPOXIA_UP 9257All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
LUI_THYROID_CANCER_PAX8_PPARG_DN 4529All SZGR genes in this pathway
HWANG_PROSTATE_CANCER_MARKERS 2819All SZGR genes in this pathway
LI_AMPLIFIED_IN_LUNG_CANCER 178108All SZGR genes in this pathway
MATTIOLI_MGUS_VS_PCL 11662All SZGR genes in this pathway
GRASEMANN_RETINOBLASTOMA_WITH_6P_AMPLIFICATION 1414All SZGR genes in this pathway
LUI_TARGETS_OF_PAX8_PPARG_FUSION 3423All SZGR genes in this pathway
SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM 15993All SZGR genes in this pathway
SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_DN 4734All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP 16792All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
SCIAN_CELL_CYCLE_TARGETS_OF_TP53_AND_TP73_DN 2214All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN 8151All SZGR genes in this pathway
MORI_PRE_BI_LYMPHOCYTE_UP 8054All SZGR genes in this pathway
MORI_LARGE_PRE_BII_LYMPHOCYTE_UP 8649All SZGR genes in this pathway
MORI_IMMATURE_B_LYMPHOCYTE_DN 9055All SZGR genes in this pathway
SANA_RESPONSE_TO_IFNG_DN 8556All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_DN 7657All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_DN 7345All SZGR genes in this pathway
MA_MYELOID_DIFFERENTIATION_UP 3929All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN 172107All SZGR genes in this pathway
MUNSHI_MULTIPLE_MYELOMA_UP 8152All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_UP 6941All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_DN 215132All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP 12375All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_MACROPHAGE 7750All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM 6647All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_FIBROBLAST 13293All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
ALONSO_METASTASIS_EMT_UP 3624All SZGR genes in this pathway
ALONSO_METASTASIS_UP 198128All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_DN 175103All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 163102All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN 193112All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 14386All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_M_G1 14895All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1512733m8hsa-miR-151brainACUAGACUGAAGCUCCUUGAGG
miR-181156162m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-324-5p124130m8hsa-miR-324-5pCGCAUCCCCUAGGGCAUUGGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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