Gene Page: KDM5A

Summary ?
GeneID5927
SymbolKDM5A
SynonymsRBBP-2|RBBP2|RBP2
Descriptionlysine demethylase 5A
ReferenceMIM:180202|HGNC:HGNC:9886|Ensembl:ENSG00000073614|HPRD:08915|Vega:OTTHUMG00000168055
Gene typeprotein-coding
Map location12p11
Pascal p-value0.586
Sherlock p-value0.874
Fetal beta0.38
SupportAscano FMRP targets
Chromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HEXDC0.840.84
PCBP40.810.84
ACD0.810.77
UCKL10.810.81
FBXL60.810.79
CLN30.800.81
PLSCR30.800.82
ZBTB480.790.79
RFNG0.790.80
QTRT10.790.82
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.27-0.56-0.59
AF347015.31-0.54-0.58
MT-CO2-0.52-0.57
MT-CYB-0.52-0.57
AF347015.8-0.52-0.58
AF347015.15-0.51-0.58
MT-ATP8-0.49-0.64
AF347015.33-0.49-0.53
ABCG2-0.49-0.52
AF347015.21-0.48-0.62

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BGLAPBGP | OC | PMF1bone gamma-carboxyglutamate (gla) proteinRBP2 interacts with OC promoter.BIND15949438 
BRD2D6S113E | DKFZp686N0336 | FLJ31942 | FSH | FSRG1 | KIAA9001 | NAT | RING3 | RNF3bromodomain containing 2RBP2 interacts with BRD2 promoter.BIND15949438 
BRD8SMAP | SMAP2 | p120bromodomain containing 8RBP2 interacts with BRD8 promoter.BIND15949438 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1Affinity Capture-Western
Reconstituted Complex		BioGRID11358960 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1Rbp2 interacts with ER.BIND11358960 
LMO2RBTN2 | RBTNL1 | RHOM2 | TTG2LIM domain only 2 (rhombotin-like 1)-HPRD,BioGRID9129143 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)Reconstituted ComplexBioGRID11358960 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)Rbp2 interacts with GR. This interaction was modeled on a demonstrated interaction between human Rbp2 and rat GR.BIND11358960 
RARANR1B1 | RARretinoic acid receptor, alphaReconstituted ComplexBioGRID11358960 
RARANR1B1 | RARretinoic acid receptor, alphaRbp2 interacts with RAR.BIND11358960 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1-HPRD,BioGRID7935440 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1Rbp2 interacts with Rb. This interaction was modeled on a demonstrated interaction between human Rbp2 and Rb from an unspecified species.BIND11358960 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1pRB interacts with RBP2.BIND15949438 
RBL1CP107 | MGC40006 | PRB1 | p107retinoblastoma-like 1 (p107)-HPRD,BioGRID7935440 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding protein-HPRD,BioGRID7935440 
VDRNR1I1vitamin D (1,25- dihydroxyvitamin D3) receptor-HPRD,BioGRID11358960 
VDRNR1I1vitamin D (1,25- dihydroxyvitamin D3) receptorRbp2 interacts with VDR.BIND11358960 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK DN 13797All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP 197135All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION HBZ 4127All SZGR 2.0 genes in this pathway
JAERVINEN AMPLIFIED IN LARYNGEAL CANCER 4024All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483336All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309206All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA UP 5035All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP 7149All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
JAZAERI BREAST CANCER BRCA1 VS BRCA2 UP 4928All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318220All SZGR 2.0 genes in this pathway
TRACEY RESISTANCE TO IFNA2 DN 3223All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
CHO NR4A1 TARGETS 3322All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200115All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221135All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN 10677All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 10HR UP 5438All SZGR 2.0 genes in this pathway