Gene Page: BCL6

Summary ?
GeneID604
SymbolBCL6
SynonymsBCL5|BCL6A|LAZ3|ZBTB27|ZNF51
DescriptionB-cell CLL/lymphoma 6
ReferenceMIM:109565|HGNC:HGNC:1001|Ensembl:ENSG00000113916|HPRD:00180|Vega:OTTHUMG00000156441
Gene typeprotein-coding
Map location3q27
Pascal p-value0.753
Sherlock p-value0.307
Fetal beta1.159
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg010579623187463312BCL61.28E-9-0.021.34E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs597544chr649703856BCL66040.12trans
rs16955618chr1529937543BCL66040.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BCORL10.970.97
NCOA60.970.97
CASP20.960.94
PHF20.960.95
PHF120.960.96
CELSR30.960.97
POGZ0.950.96
ZMIZ10.950.97
BCL9L0.950.94
KDM4B0.950.96
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C5orf53-0.71-0.81
HLA-F-0.69-0.76
AIFM3-0.69-0.76
S100B-0.69-0.86
AF347015.31-0.68-0.90
SERPINB6-0.67-0.74
AF347015.27-0.67-0.88
TSC22D4-0.67-0.78
ACOT13-0.67-0.70
MT-CO2-0.67-0.91

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCL6BBAZF | ZBTB28 | ZNF62B-cell CLL/lymphoma 6, member B (zinc finger protein)-HPRD9632807 
BCORANOP2 | FLJ20285 | FLJ38041 | KIAA1575 | MAA2 | MCOPS2 | MGC131961 | MGC71031BCL6 co-repressor-HPRD,BioGRID10898795 
CCL3G0S19-1 | LD78ALPHA | MIP-1-alpha | MIP1A | SCYA3chemokine (C-C motif) ligand 3BCL6 interacts with the CCL3 promoter region.BIND15531890 
CCND2KIAK0002 | MGC102758cyclin D2BCL6 interacts with the CCND2 promoter region.BIND15531890 
CHD3Mi-2a | Mi2-ALPHA | ZFHchromodomain helicase DNA binding protein 3BCL6 interacts with Mi2.BIND15454082 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1Affinity Capture-WesternBioGRID9627120 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4-HPRD,BioGRID11929873 
HDAC5FLJ90614 | HD5 | NY-CO-9histone deacetylase 5-HPRD,BioGRID11929873 
HDAC7DKFZp586J0917 | FLJ99588 | HD7A | HDAC7Ahistone deacetylase 7Affinity Capture-Western
Reconstituted Complex		BioGRID11929873 
HDAC9DKFZp779K1053 | HD7 | HDAC | HDAC7 | HDAC7B | HDAC9B | HDAC9FL | HDRP | KIAA0744 | MITRhistone deacetylase 9-HPRD12590135 
IRF4LSIRF | MUM1interferon regulatory factor 4-HPRD,BioGRID10601358 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID12165517 
JUNBAP-1jun B proto-oncogene-HPRD,BioGRID12165517 
JUNDAP-1jun D proto-oncogene-HPRD,BioGRID12165517 
MBD3-methyl-CpG binding domain protein 3BCL6 interacts with MBD3.BIND15454082 
MTA3KIAA1266metastasis associated 1 family, member 3BCL6 interacts with MTA3.BIND15454082 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1-HPRD,BioGRID10898795 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2-HPRD,BioGRID9765306 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2The lateral groove motif in the BTB domain of BCL6 interacts with the BBD motif of SMRT.BIND15531890 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemiaTwo-hybridBioGRID11175338 
PPARDFAAR | MGC3931 | NR1C2 | NUC1 | NUCI | NUCII | PPAR-beta | PPARBperoxisome proliferator-activated receptor deltaPPAR-delta interacts with BCL-6. This interaction was modelled on a demonstrated interaction between mouse PPAR-delta and human BCL-6.BIND12970571 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)Reconstituted ComplexBioGRID9765306 
SP1-Sp1 transcription factor-HPRD12004059 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53BCL6 interacts with the p53 promoter region.BIND15577913 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16-HPRD,BioGRID11175338 
ZBTB7ADKFZp547O146 | FBI-1 | FBI1 | LRF | MGC99631 | ZBTB7 | ZNF857A | pokemonzinc finger and BTB domain containing 7A-HPRD,BioGRID9927193 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID IL4 2PATHWAY 6543All SZGR 2.0 genes in this pathway
PID HDAC CLASSII PATHWAY 3427All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY 4943All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY 13794All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 11679All SZGR 2.0 genes in this pathway
RODRIGUES DCC TARGETS DN 12184All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372227All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER ADVANCED VS EARLY UP 175120All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205127All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL UP 9564All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501327All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA SIZE UP 2312All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID DN 6745All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK DN 3927All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP 271175All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK DN 7954All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS DN 6244All SZGR 2.0 genes in this pathway
STREICHER LSM1 TARGETS UP 4434All SZGR 2.0 genes in this pathway
MARTIN INTERACT WITH HDAC 4431All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 7 86All SZGR 2.0 genes in this pathway
DAUER STAT3 TARGETS UP 4935All SZGR 2.0 genes in this pathway
MURATA VIRULENCE OF H PILORI 2416All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
NAKAYAMA FRA2 TARGETS 4327All SZGR 2.0 genes in this pathway
FUJIWARA PARK2 IN LIVER CANCER DN 55All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR UP 11679All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 7 2722All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP 14085All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE DN 6643All SZGR 2.0 genes in this pathway
KIM GERMINAL CENTER T HELPER UP 6642All SZGR 2.0 genes in this pathway
KANNAN TP53 TARGETS UP 5840All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6 14498All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN 6647All SZGR 2.0 genes in this pathway
LU IL4 SIGNALING 9456All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207145All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203130All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS UP 4834All SZGR 2.0 genes in this pathway
ABRAHAM ALPC VS MULTIPLE MYELOMA UP 2622All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183111All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING DN 6844All SZGR 2.0 genes in this pathway
SCHURINGA STAT5A TARGETS DN 1810All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN 228146All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS UP 8951All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART UP 10369All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 4 4832All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE UP 9564All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261166All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491310All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578341All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN 154101All SZGR 2.0 genes in this pathway
MATZUK SPERMATOCYTE 7255All SZGR 2.0 genes in this pathway
CLIMENT BREAST CANCER COPY NUMBER UP 2320All SZGR 2.0 genes in this pathway
JIANG TIP30 TARGETS UP 4628All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS UP 153107All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN 209137All SZGR 2.0 genes in this pathway
LEE DOUBLE POLAR THYMOCYTE 2717All SZGR 2.0 genes in this pathway
CROONQUIST NRAS VS STROMAL STIMULATION DN 9965All SZGR 2.0 genes in this pathway
ZHAN LATE DIFFERENTIATION GENES DN 1610All SZGR 2.0 genes in this pathway
SCHOEN NFKB SIGNALING 3426All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS AND CYCLIC RGD 2115All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR UP 10165All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN 210141All SZGR 2.0 genes in this pathway
CHIARETTI T ALL REFRACTORY TO THERAPY 3018All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1 6850All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G24 2819All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222147All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
DELPUECH FOXO3 TARGETS UP 6849All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP 194133All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP 344215All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL 160106All SZGR 2.0 genes in this pathway
BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE 15186All SZGR 2.0 genes in this pathway
ZWANG DOWN BY 2ND EGF PULSE 293119All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway