Summary ?
GeneID6136
SymbolRPL12
SynonymsL12
Descriptionribosomal protein L12
ReferenceMIM:180475|HGNC:HGNC:10302|Ensembl:ENSG00000197958|HPRD:01603|Vega:OTTHUMG00000020704
Gene typeprotein-coding
Map location9q34
Pascal p-value0.004
Sherlock p-value0.99
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
SupportG2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg145196829130213309LRSAM1;RPL121.096E-40.5410.028DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs3705469659130177010RPL12ENSG00000197958.81.932E-7036674gtex_brain_ba24
rs109876459130181223RPL12ENSG00000197958.81.671E-8032461gtex_brain_ba24
rs39243089130185385RPL12ENSG00000197958.81.863E-6028299gtex_brain_ba24
rs70350399130187473RPL12ENSG00000197958.81.629E-8026211gtex_brain_ba24
rs108192929130188676RPL12ENSG00000197958.89.977E-8025008gtex_brain_ba24
rs70337799130190810RPL12ENSG00000197958.81.713E-8022874gtex_brain_ba24
rs132920969130191186RPL12ENSG00000197958.81.743E-8022498gtex_brain_ba24
rs107396929130192765RPL12ENSG00000197958.81.909E-8020919gtex_brain_ba24
rs44004869130193725RPL12ENSG00000197958.82.282E-8019959gtex_brain_ba24
rs64787739130194487RPL12ENSG00000197958.81.083E-7019197gtex_brain_ba24
rs44004879130194495RPL12ENSG00000197958.82.532E-7019189gtex_brain_ba24
rs46411639130194536RPL12ENSG00000197958.86.549E-8019148gtex_brain_ba24
rs46283519130196233RPL12ENSG00000197958.82.571E-8017451gtex_brain_ba24
rs109876509130196537RPL12ENSG00000197958.82.654E-8017147gtex_brain_ba24
rs78707379130196807RPL12ENSG00000197958.82.911E-8016877gtex_brain_ba24
rs39233099130197185RPL12ENSG00000197958.84.101E-8016499gtex_brain_ba24
rs45047459130197414RPL12ENSG00000197958.85.477E-8016270gtex_brain_ba24
rs78530479130198100RPL12ENSG00000197958.85.477E-8015584gtex_brain_ba24
rs45001799130198342RPL12ENSG00000197958.85.477E-8015342gtex_brain_ba24
rs64787769130198866RPL12ENSG00000197958.85.477E-8014818gtex_brain_ba24
rs64787779130199370RPL12ENSG00000197958.85.477E-8014314gtex_brain_ba24
rs64787809130200433RPL12ENSG00000197958.85.611E-8013251gtex_brain_ba24
rs64787819130200450RPL12ENSG00000197958.81.415E-7013234gtex_brain_ba24
rs78519919130201265RPL12ENSG00000197958.88.986E-8012419gtex_brain_ba24
rs78691019130201525RPL12ENSG00000197958.85.477E-8012159gtex_brain_ba24
rs78690239130201678RPL12ENSG00000197958.85.477E-8012006gtex_brain_ba24
rs78698239130202089RPL12ENSG00000197958.85.477E-8011595gtex_brain_ba24
rs78594579130202596RPL12ENSG00000197958.85.477E-8011088gtex_brain_ba24
rs70468759130202907RPL12ENSG00000197958.85.477E-8010777gtex_brain_ba24
rs64787849130203840RPL12ENSG00000197958.85.477E-809844gtex_brain_ba24
rs22656869130204776RPL12ENSG00000197958.85.477E-808908gtex_brain_ba24
rs22479059130208376RPL12ENSG00000197958.85.477E-805308gtex_brain_ba24
rs22477819130208924RPL12ENSG00000197958.85.477E-804760gtex_brain_ba24
rs11394009130210111RPL12ENSG00000197958.89.554E-903573gtex_brain_ba24
rs22475739130210946RPL12ENSG00000197958.85.477E-802738gtex_brain_ba24
rs22473229130212876RPL12ENSG00000197958.85.477E-80808gtex_brain_ba24
rs22473109130213110RPL12ENSG00000197958.85.477E-80574gtex_brain_ba24
rs22473039130213298RPL12ENSG00000197958.85.477E-80386gtex_brain_ba24
rs22446249130213508RPL12ENSG00000197958.85.504E-80176gtex_brain_ba24
rs22444689130215279RPL12ENSG00000197958.85.477E-80-1595gtex_brain_ba24
rs22439069130219669RPL12ENSG00000197958.85.477E-80-5985gtex_brain_ba24
rs22439039130219743RPL12ENSG00000197958.89.376E-80-6059gtex_brain_ba24
rs22438989130219990RPL12ENSG00000197958.85.042E-70-6306gtex_brain_ba24
rs78747329130220673RPL12ENSG00000197958.81.271E-70-6989gtex_brain_ba24
rs2001910279130220695RPL12ENSG00000197958.81.931E-70-7011gtex_brain_ba24
rs78746409130220696RPL12ENSG00000197958.81.841E-60-7012gtex_brain_ba24
rs2008771379130220697RPL12ENSG00000197958.87.002E-80-7013gtex_brain_ba24
rs78747439130220698RPL12ENSG00000197958.82.325E-70-7014gtex_brain_ba24
rs22437849130220956RPL12ENSG00000197958.85.477E-80-7272gtex_brain_ba24
rs22437679130221388RPL12ENSG00000197958.85.477E-80-7704gtex_brain_ba24
rs24888999130221698RPL12ENSG00000197958.85.477E-80-8014gtex_brain_ba24
rs22436639130222452RPL12ENSG00000197958.86.783E-80-8768gtex_brain_ba24
rs22544379130224927RPL12ENSG00000197958.85.477E-80-11243gtex_brain_ba24
rs22436089130226909RPL12ENSG00000197958.82.505E-80-13225gtex_brain_ba24
rs22540419130228444RPL12ENSG00000197958.85.493E-80-14760gtex_brain_ba24
rs22539299130228511RPL12ENSG00000197958.88.35E-80-14827gtex_brain_ba24
rs22539289130228569RPL12ENSG00000197958.83.084E-70-14885gtex_brain_ba24
rs22536699130230514RPL12ENSG00000197958.81.972E-70-16830gtex_brain_ba24
rs22536399130231417RPL12ENSG00000197958.85.481E-80-17733gtex_brain_ba24
rs123405609130234154RPL12ENSG00000197958.86.018E-80-20470gtex_brain_ba24
rs29958239130234647RPL12ENSG00000197958.81.735E-70-20963gtex_brain_ba24
rs22500249130238024RPL12ENSG00000197958.81.955E-70-24340gtex_brain_ba24
rs22499409130238540RPL12ENSG00000197958.85.804E-80-24856gtex_brain_ba24
rs2013240489130241372RPL12ENSG00000197958.81.561E-60-27688gtex_brain_ba24
rs22465799130244255RPL12ENSG00000197958.85.815E-80-30571gtex_brain_ba24
rs22460119130248885RPL12ENSG00000197958.81.402E-70-35201gtex_brain_ba24
rs22460009130249144RPL12ENSG00000197958.84.987E-80-35460gtex_brain_ba24
rs13178449130252312RPL12ENSG00000197958.82.317E-60-38628gtex_brain_ba24
rs27984289130257205RPL12ENSG00000197958.85.815E-80-43521gtex_brain_ba24
rs24889039130262076RPL12ENSG00000197958.85.815E-80-48392gtex_brain_ba24
rs22656889130262597RPL12ENSG00000197958.81.477E-60-48913gtex_brain_ba24
rs22453899130266566RPL12ENSG00000197958.84.012E-70-52882gtex_brain_ba24
rs70337799130190810RPL12ENSG00000197958.82.943E-6022874gtex_brain_putamen_basal
rs132920969130191186RPL12ENSG00000197958.82.756E-6022498gtex_brain_putamen_basal
rs107396929130192765RPL12ENSG00000197958.82.098E-6020919gtex_brain_putamen_basal
rs64787739130194487RPL12ENSG00000197958.87.585E-7019197gtex_brain_putamen_basal
rs44004879130194495RPL12ENSG00000197958.89.371E-8019189gtex_brain_putamen_basal
rs46411639130194536RPL12ENSG00000197958.81.087E-6019148gtex_brain_putamen_basal
rs46283519130196233RPL12ENSG00000197958.81.184E-6017451gtex_brain_putamen_basal
rs109876509130196537RPL12ENSG00000197958.81.13E-6017147gtex_brain_putamen_basal
rs78707379130196807RPL12ENSG00000197958.81.104E-6016877gtex_brain_putamen_basal
rs39233099130197185RPL12ENSG00000197958.81.104E-6016499gtex_brain_putamen_basal
rs45047459130197414RPL12ENSG00000197958.81.104E-6016270gtex_brain_putamen_basal
rs78530479130198100RPL12ENSG00000197958.81.104E-6015584gtex_brain_putamen_basal
rs45001799130198342RPL12ENSG00000197958.81.104E-6015342gtex_brain_putamen_basal
rs64787769130198866RPL12ENSG00000197958.88.914E-7014818gtex_brain_putamen_basal
rs64787779130199370RPL12ENSG00000197958.81.104E-6014314gtex_brain_putamen_basal
rs64787809130200433RPL12ENSG00000197958.81.144E-6013251gtex_brain_putamen_basal
rs64787819130200450RPL12ENSG00000197958.82.296E-6013234gtex_brain_putamen_basal
rs78519919130201265RPL12ENSG00000197958.86.85E-7012419gtex_brain_putamen_basal
rs78691019130201525RPL12ENSG00000197958.81.104E-6012159gtex_brain_putamen_basal
rs78690239130201678RPL12ENSG00000197958.81.104E-6012006gtex_brain_putamen_basal
rs78698239130202089RPL12ENSG00000197958.81.104E-6011595gtex_brain_putamen_basal
rs78594579130202596RPL12ENSG00000197958.81.104E-6011088gtex_brain_putamen_basal
rs70468759130202907RPL12ENSG00000197958.81.104E-6010777gtex_brain_putamen_basal
rs64787849130203840RPL12ENSG00000197958.81.104E-609844gtex_brain_putamen_basal
rs22656869130204776RPL12ENSG00000197958.88.914E-708908gtex_brain_putamen_basal
rs22479059130208376RPL12ENSG00000197958.81.104E-605308gtex_brain_putamen_basal
rs22477819130208924RPL12ENSG00000197958.81.104E-604760gtex_brain_putamen_basal
rs22475739130210946RPL12ENSG00000197958.88.914E-702738gtex_brain_putamen_basal
rs22473229130212876RPL12ENSG00000197958.81.104E-60808gtex_brain_putamen_basal
rs22473109130213110RPL12ENSG00000197958.88.645E-70574gtex_brain_putamen_basal
rs22473039130213298RPL12ENSG00000197958.81.104E-60386gtex_brain_putamen_basal
rs22446249130213508RPL12ENSG00000197958.81.104E-60176gtex_brain_putamen_basal
rs22444689130215279RPL12ENSG00000197958.81.104E-60-1595gtex_brain_putamen_basal
rs22439069130219669RPL12ENSG00000197958.81.104E-60-5985gtex_brain_putamen_basal
rs22439039130219743RPL12ENSG00000197958.81.001E-60-6059gtex_brain_putamen_basal
rs22438989130219990RPL12ENSG00000197958.81.562E-60-6306gtex_brain_putamen_basal
rs2001910279130220695RPL12ENSG00000197958.85.716E-70-7011gtex_brain_putamen_basal
rs2008771379130220697RPL12ENSG00000197958.87.375E-70-7013gtex_brain_putamen_basal
rs78747439130220698RPL12ENSG00000197958.82.208E-60-7014gtex_brain_putamen_basal
rs22437849130220956RPL12ENSG00000197958.81.104E-60-7272gtex_brain_putamen_basal
rs22437679130221388RPL12ENSG00000197958.81.104E-60-7704gtex_brain_putamen_basal
rs24888999130221698RPL12ENSG00000197958.81.104E-60-8014gtex_brain_putamen_basal
rs22436639130222452RPL12ENSG00000197958.85.329E-70-8768gtex_brain_putamen_basal
rs22544379130224927RPL12ENSG00000197958.81.104E-60-11243gtex_brain_putamen_basal
rs22436089130226909RPL12ENSG00000197958.81.478E-60-13225gtex_brain_putamen_basal
rs22540419130228444RPL12ENSG00000197958.81.084E-60-14760gtex_brain_putamen_basal
rs22539299130228511RPL12ENSG00000197958.87.984E-70-14827gtex_brain_putamen_basal
rs22536699130230514RPL12ENSG00000197958.83.119E-60-16830gtex_brain_putamen_basal
rs22536399130231417RPL12ENSG00000197958.81.105E-60-17733gtex_brain_putamen_basal
rs22515519130284652RPL12ENSG00000197958.82.059E-60-70968gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RPL380.970.95
RPL27A0.960.95
RPS80.960.96
RPL19P120.950.94
RPL10A0.950.92
RPS25P80.950.93
RPS19P30.950.96
RPL180.950.93
RPL300.940.95
RPL370.940.96
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ATP10A-0.60-0.77
FBXO2-0.58-0.70
LDHD-0.57-0.69
HLA-F-0.57-0.66
ME1-0.57-0.70
ACSL6-0.56-0.76
MAP3K5-0.56-0.75
EDN3-0.56-0.70
EPB41L2-0.56-0.75
CCNI2-0.56-0.72

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG RIBOSOME 8843All SZGR 2.0 genes in this pathway
REACTOME TRANSLATION 22275All SZGR 2.0 genes in this pathway
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 17953All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE CHAIN ELONGATION 15341All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION 17651All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284128All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330155All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA LIFE CYCLE 20372All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION 16947All SZGR 2.0 genes in this pathway
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 17657All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING DN 4629All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR DN 214133All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
KONG E2F3 TARGETS 9758All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS UP 201127All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229137All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC UP 5430All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA UP 6140All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN 12179All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP 6440All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP 222139All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS PRENATAL 4233All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428266All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311205All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS 9268All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D DN 6435All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354216All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL DN 12775All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245159All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN 175103All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN 10265All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457302All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668419All SZGR 2.0 genes in this pathway
IRITANI MAD1 TARGETS DN 4730All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
HOLLEMAN VINCRISTINE RESISTANCE B ALL DN 1510All SZGR 2.0 genes in this pathway
HOLLEMAN VINCRISTINE RESISTANCE ALL DN 1911All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL DN 214124All SZGR 2.0 genes in this pathway