Gene Page

Gene Page: LIN7B

Summary

GeneID

64130

Symbol

LIN7B

Synonyms

LIN-7B|MALS-2|MALS2|VELI2

Description

lin-7 homolog B (C. elegans)

Locus tag

Gene type

protein-coding

Map location

19q13.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 4

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.1336

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IPI

16192269

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007269

neurotransmitter secretion

IEA

neuron, axon, Synap, serotonin, Neurotransmitter, dopamine (GO term level: 8)

GO:0006887

exocytosis

IEA

GO:0015031

protein transport

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005923

tight junction

IEA

Brain (GO term level: 10)

GO:0019717

synaptosome

IEA

Synap, Brain (GO term level: 7)

GO:0045211

postsynaptic membrane

IEA

Synap, Neurotransmitter (GO term level: 5)

GO:0045202

synapse

IEA

neuron, Synap, Neurotransmitter, Glial (GO term level: 2)

GO:0005886

plasma membrane

IEA

GO:0016323

basolateral plasma membrane

IEA

GO:0030054

cell junction

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACCN3	ASIC3 \| DRASIC \| SLNAC1 \| TNaC1	amiloride-sensitive cation channel 3	-	HPRD,BioGRID	15317815
ACCN3	ASIC3 \| DRASIC \| SLNAC1 \| TNaC1	amiloride-sensitive cation channel 3	ASIC3 interacts with LIN-7B.	BIND	15317815
APBA1	D9S411E \| MINT1 \| X11 \| X11A \| X11ALPHA	amyloid beta (A4) precursor protein-binding, family A, member 1	-	HPRD,BioGRID	9753324
BAIAP2	BAP2 \| IRSP53	BAI1-associated protein 2	-	HPRD	14596909
CASK	CAGH39 \| CMG \| FLJ22219 \| FLJ31914 \| LIN2 \| MICPCH \| TNRC8	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	-	HPRD	11742811
CASK	CAGH39 \| CMG \| FLJ22219 \| FLJ31914 \| LIN2 \| MICPCH \| TNRC8		Affinity Capture-Western	BioGRID	14960569
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	in vivo	BioGRID	10341223
GRIN2B	MGC142178 \| MGC142180 \| NMDAR2B \| NR2B \| hNR3	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	in vitro in vivo	BioGRID	10341223
KCNJ12	FLJ14167 \| IRK2 \| KCNJN1 \| Kir2.2 \| Kir2.2v \| hIRK \| hIRK1 \| hkir2.2x \| kcnj12x	potassium inwardly-rectifying channel, subfamily J, member 12	Affinity Capture-Western Reconstituted Complex	BioGRID	14960569 \|15024025
KCNJ4	HIR \| HIRK2 \| HRK1 \| IRK3 \| Kir2.3 \| MGC142066 \| MGC142068	potassium inwardly-rectifying channel, subfamily J, member 4	Affinity Capture-Western Two-hybrid	BioGRID	11742811

Pathway annotation

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-200bc/429	41	47	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.