Gene Page: BNIP3

Summary ?
GeneID664
SymbolBNIP3
SynonymsNIP3
DescriptionBCL2/adenovirus E1B 19kDa interacting protein 3
ReferenceMIM:603293|HGNC:HGNC:1084|HPRD:04482|
Gene typeprotein-coding
Map location10q26.3
Pascal p-value0.563
Sherlock p-value0.721
Fetal beta-1.725
DMG1 (# studies)
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.03487 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg2204528810134258421BNIP39.407E-44.326DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10994209chr1061877705BNIP36640.07trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SOX180.700.64
FOXQ10.680.62
TBX30.670.61
EPAS10.670.62
SEMA3G0.660.64
HSPA12B0.650.66
FOXF10.640.56
GPER0.640.57
GATA20.640.62
TBX20.640.60
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZNF32-0.43-0.48
COMMD3-0.42-0.45
FRG1-0.41-0.44
C12orf45-0.41-0.48
POLB-0.40-0.43
OXSM-0.39-0.42
RPL31-0.39-0.47
UBE2D2-0.39-0.35
PFDN5-0.39-0.47
C18orf21-0.38-0.38

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0042803protein homodimerization activityIDA9396766 |10381623 
GO:0046982protein heterodimerization activityIDA10381623 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0051402neuron apoptosisISSneuron, axon, dendrite (GO term level: 7)-
GO:0001666response to hypoxiaISS-
GO:0006309DNA fragmentation during apoptosisIDA10891486 
GO:0006338chromatin remodelingIDA10891486 
GO:0008219cell deathIDA10891486 
GO:0008219cell deathISS-
GO:0006917induction of apoptosisIDA9396766 |9973195 |10381623 
GO:0008634negative regulation of survival gene product expressionIDA9973195 
GO:0006800oxygen and reactive oxygen species metabolic processIDA10891486 
GO:0006916anti-apoptosisTAS7954800 
GO:0051607defense response to virusIDA9973195 
GO:0045837negative regulation of membrane potentialIDA10891486 
GO:0046902regulation of mitochondrial membrane permeabilityIDA10891486 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030425dendriteISSneuron, axon, dendrite (GO term level: 6)-
GO:0005634nucleusISS-
GO:0005635nuclear envelopeIDA7954800 
GO:0005654nucleoplasmISS-
GO:0005737cytoplasmISS-
GO:0005739mitochondrionIDA7954800 |9396766 
GO:0005739mitochondrionTAS9973195 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0031307integral to mitochondrial outer membraneIDA10891486 
GO:0031966mitochondrial membraneIDA10891486 
GO:0031966mitochondrial membraneIMP9396766 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID MTOR 4PATHWAY 6955All SZGR 2.0 genes in this pathway
PID HIF1 TFPATHWAY 6652All SZGR 2.0 genes in this pathway
WINTER HYPOXIA UP 9257All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN 309191All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493298All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
PRAMOONJAGO SOX4 TARGETS UP 5238All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
GRABARCZYK BCL11B TARGETS UP 8140All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367220All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275168All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP 171112All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA BY DMOG UP 13085All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A TARGETS DN 9158All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A AND HIF2A TARGETS DN 10472All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 DN 6743All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293179All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP 5540All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN 234147All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GALLUZZI PERMEABILIZE MITOCHONDRIA 4331All SZGR 2.0 genes in this pathway
DUTTA APOPTOSIS VIA NFKB 3325All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326213All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP 176111All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP 227137All SZGR 2.0 genes in this pathway
MAINA VHL TARGETS DN 1814All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203134All SZGR 2.0 genes in this pathway
WANG RESPONSE TO BEXAROTENE UP 3417All SZGR 2.0 genes in this pathway
GROSS ELK3 TARGETS DN 3217All SZGR 2.0 genes in this pathway
GROSS HIF1A TARGETS DN 2515All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN 11078All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP 142104All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 8HR 5 UP 167All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR UP 11679All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER PROGRESSION G2 G3 UP 2814All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK 169111All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER METASTASIS DN 12165All SZGR 2.0 genes in this pathway
SMITH LIVER CANCER 4527All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207145All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT UP 8961All SZGR 2.0 genes in this pathway
JAIN NFKB SIGNALING 7544All SZGR 2.0 genes in this pathway
MENSE HYPOXIA UP 9871All SZGR 2.0 genes in this pathway
BRUNO HEMATOPOIESIS 6648All SZGR 2.0 genes in this pathway
KIM HYPOXIA 2521All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS RESPONSE 3528All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
HARRIS HYPOXIA 8164All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371218All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 2 5034All SZGR 2.0 genes in this pathway
LEONARD HYPOXIA 4735All SZGR 2.0 genes in this pathway
SATO SILENCED EPIGENETICALLY IN PANCREATIC CANCER 4930All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261183All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198132All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C1 7245All SZGR 2.0 genes in this pathway
GEISS RESPONSE TO DSRNA UP 3829All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311205All SZGR 2.0 genes in this pathway
SEMENZA HIF1 TARGETS 3632All SZGR 2.0 genes in this pathway
SAFFORD T LYMPHOCYTE ANERGY 8754All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419273All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6 189112All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373196All SZGR 2.0 genes in this pathway
COATES MACROPHAGE M1 VS M2 DN 7844All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 7451All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242168All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
MELLMAN TUT1 TARGETS DN 4729All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA DN 6845All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 0 7654All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2 VIA ERCC6 DN 4631All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS UP 7547All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242159All SZGR 2.0 genes in this pathway
QI HYPOXIA 14096All SZGR 2.0 genes in this pathway
SUBTIL PROGESTIN TARGETS 3625All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229135All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 2 UP 1512All SZGR 2.0 genes in this pathway
FARDIN HYPOXIA 9 76All SZGR 2.0 genes in this pathway
FARDIN HYPOXIA 11 3229All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR DN 11469All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1457968031A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU