Gene Page: STAT1

Summary ?
GeneID6772
SymbolSTAT1
SynonymsCANDF7|IMD31A|IMD31B|IMD31C|ISGF-3|STAT91
Descriptionsignal transducer and activator of transcription 1
ReferenceMIM:600555|HGNC:HGNC:11362|Ensembl:ENSG00000115415|HPRD:02777|Vega:OTTHUMG00000132699
Gene typeprotein-coding
Map location2q32.2
Pascal p-value0.007
Sherlock p-value0.982
Fetal beta-1.421
eGeneMyers' cis & trans
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.164 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17097182chr165903444STAT167720.1trans
rs17092900chr173003409STAT167721.514E-6trans
rs17121311chr1100314968STAT167720.2trans
rs7532142chr1157362311STAT167720.08trans
rs6427374chr1157362489STAT167720.08trans
rs10494571chr1183930700STAT167720.06trans
rs16857588chr211675145STAT167720trans
snp_a-21429220STAT167720.04trans
rs1900263chr280376061STAT167720.01trans
rs10496239chr280376968STAT167720.01trans
rs11679783chr280377391STAT167720.01trans
rs17018721chr280385148STAT167720.03trans
rs2862022chr280388509STAT167720.01trans
rs17043176chr2114025371STAT167720trans
rs17490240chr2146573997STAT167720.06trans
rs842573chr2184293146STAT167720.07trans
rs11897086chr2184596267STAT167720.14trans
rs10187085chr2184614775STAT167720.06trans
rs9989867chr2184628012STAT167720.06trans
rs17033273chr310676696STAT167720.08trans
rs7637875chr340594263STAT167720.06trans
rs277655chr3100044586STAT167720.02trans
rs890527chr3140774852STAT167720.01trans
rs6789808chr3154492082STAT167720.09trans
rs7612673chr3154499328STAT167723.968E-4trans
rs17502924chr416968009STAT167720.07trans
rs13110653chr416973010STAT167720.09trans
rs10461085chr430717743STAT167720.18trans
rs11942278chr458922687STAT167720.05trans
rs6551878chr465690588STAT167720.16trans
rs7688236chr486804077STAT167720.17trans
rs2653828chr4173851087STAT167720.03trans
rs159171chr521186325STAT167720.13trans
rs1678893chr531763244STAT167721.603E-7trans
rs10515260chr597076547STAT167720.02trans
rs4705861chr5131800763STAT167720.09trans
rs17101114chr5143246001STAT167720.18trans
rs10516136chr5176381368STAT167720.04trans
rs13176869chr5179203478STAT167726.028E-5trans
rs9396602chr615766500STAT167720.18trans
rs1240825chr616862984STAT167720.08trans
rs7741955chr684829621STAT167720.08trans
rs12524136chr684935440STAT167722.815E-4trans
rs16883826chr691671158STAT167720.01trans
rs9397692chr6154487314STAT167727.187E-6trans
rs10485060chr6154516100STAT167729.442E-6trans
rs9384190chr6154524473STAT167721.354E-5trans
rs17292544chr6154544809STAT167721.017E-7trans
rs6462122chr729137630STAT167720.12trans
rs17171716chr740505332STAT167720.01trans
rs17160749chr777689922STAT167720.01trans
rs3779321chr777691378STAT167720.01trans
rs11974883chr778068523STAT167720.01trans
rs7807249chr7131615735STAT167720.08trans
rs1355060chr8118717710STAT167720.1trans
rs2280828chr8118762435STAT167720.05trans
rs10283612chr91830285STAT167720.01trans
rs10963533chr91832589STAT167720.05trans
rs10283729chr92981636STAT167720.01trans
rs10816182chr99795184STAT167720.17trans
rs10752351chr106588016STAT167720.12trans
rs10796268chr106603916STAT167720.12trans
rs9416364chr1056253021STAT167720.11trans
rs16916549chr1063495204STAT167720.05trans
rs17111364chr1097901813STAT167720.01trans
rs894376chr1099674122STAT167720.08trans
rs10833144chr1119656451STAT167720.03trans
rs11038039chr1144530644STAT167720.04trans
rs11038047chr1144543848STAT167720.02trans
rs2508654chr11120405519STAT167720.16trans
rs17220663chr1213859583STAT167720.12trans
rs2605422chr1259148638STAT167720.15trans
rs2645865chr1259151393STAT167720.17trans
rs2712516chr1259152364STAT167720.07trans
rs3751152chr12121442063STAT167720.03trans
rs95783420STAT167720.1trans
rs4769240chr1323697920STAT167720.15trans
rs17061055chr1340835399STAT167722.821E-7trans
rs17066364chr1345515988STAT167721.066E-8trans
rs3783149chr1345582764STAT167722.319E-4trans
rs7332969chr1345612902STAT167721.066E-8trans
rs10484008chr1489376562STAT167720.1trans
rs10150770chr1495375311STAT167720.09trans
rs16955413chr1529677652STAT167721.914E-7trans
rs4457950chr1535445709STAT167720.08trans
rs16969948chr1578864785STAT167720.03trans
rs6497089chr1594163348STAT167720.16trans
rs3794689chr1671600536STAT167720.09trans
rs963303chr1673372497STAT167720.05trans
rs16955238chr1681415690STAT167721.407E-4trans
rs16955255chr1681420130STAT167724.711E-5trans
rs16955259chr1681420188STAT167721.407E-4trans
rs416841chr1686774391STAT167720.14trans
rs4303487chr1690033254STAT167720.01trans
rs8098388chr1824080746STAT167720.1trans
rs8085520chr1840184498STAT167720.13trans
rs16976379chr1840198836STAT167720.16trans
rs8105452chr1911854016STAT167720.03trans
rs8104298chr1911867512STAT167729.207E-4trans
rs16979927chr2055019249STAT167722.166E-9trans
rs2832206chr2130504653STAT167720.03trans
rs137907chr2250486591STAT167720.13trans
rs17331284chrX6962964STAT167720.04trans
rs17347454chrX23347700STAT167724.925E-9trans
rs5952435chrX47321870STAT167720.01trans
rs689365chrX97074769STAT167724.056E-5trans
rs2805901chrX138809001STAT167720.02trans
rs5953621chrX138832928STAT167720.02trans
rs1415887chrX138848048STAT167720.02trans
rs6528651chrX138878265STAT167720.02trans
rs2485732chrX138907985STAT167720.02trans
rs2491006chrX138916494STAT167720.02trans
rs17328709chrX138930939STAT167720.02trans
rs2491009chrX138944850STAT167720.02trans
rs4824924chrX139019135STAT167720.02trans
rs108561330STAT167726.683E-5trans
rs16995164chrX148536507STAT167720.03trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AMIGO10.950.94
ATP2B30.940.95
SCAMP50.930.92
CLSTN10.930.95
MADD0.930.95
STX1B0.930.91
PIP4K2C0.920.91
KIAA05130.920.92
PI4KA0.920.93
ABR0.910.93
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
DBI-0.55-0.63
RAB34-0.53-0.60
GNG11-0.52-0.57
AP002478.3-0.51-0.56
RAB13-0.51-0.60
C1orf61-0.51-0.63
C1orf54-0.50-0.58
AF347015.21-0.50-0.48
RHOC-0.48-0.56
ACSF2-0.48-0.50

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityIEA-
GO:0003700transcription factor activityIEA-
GO:0003700transcription factor activityTAS10820245 |10848577 
GO:0005062hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activityTAS8608597 
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI16306601 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006366transcription from RNA polymerase II promoterTAS9630226 
GO:0007260tyrosine phosphorylation of STAT proteinTAS10692450 
GO:0007165signal transductionIEA-
GO:0007165signal transductionTAS10973496 
GO:0009615response to virusIEA-
GO:0006919caspase activationTAS10692450 
GO:0007249I-kappaB kinase/NF-kappaB cascadeTAS10848577 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA16306601 
GO:0005634nucleusIEA-
GO:0005730nucleolusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmTAS10820245 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRA1BADRA1 | ALPHA1BARadrenergic, alpha-1B-, receptor-HPRD10652206 
BMXETK | PSCTK2 | PSCTK3BMX non-receptor tyrosine kinase-HPRD9373245 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID10792030 
C20orf185LPLUNC3 | RYA3 | dJ726C3.4chromosome 20 open reading frame 185Affinity Capture-MSBioGRID17353931 
CAMK2GCAMK | CAMK-II | CAMKG | FLJ16043 | MGC26678calcium/calmodulin-dependent protein kinase II gamma-HPRD11972023 
CREBBPCBP | KAT3A | RSTSCREB binding proteinStat1-beta interacts with CBP.BIND8986769 
CREBBPCBP | KAT3A | RSTSCREB binding proteinStat1-alpha interacts with CBP.BIND8986769 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID8986769 
CSE1LCAS | CSE1 | MGC117283 | MGC130036 | MGC130037 | XPO2CSE1 chromosome segregation 1-like (yeast)-HPRD11927559 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID12070153 
EIF1ADMGC11102eukaryotic translation initiation factor 1A domain containingTwo-hybridBioGRID16189514 
EIF2AK2EIF2AK1 | MGC126524 | PKR | PRKReukaryotic translation initiation factor 2-alpha kinase 2-HPRD,BioGRID9135145 |11278865 
ELP2FLJ10879 | SHINC-2 | STATIP1 | StIPelongation protein 2 homolog (S. cerevisiae)-HPRD,BioGRID10954736 
EP300KAT3B | p300E1A binding protein p300Affinity Capture-WesternBioGRID10464260 
EP300KAT3B | p300E1A binding protein p300Stat1-beta interacts with p300. This interaction is modelled on a demonstrated interaction between human Stat1-beta and p300 from an unspecified species.BIND8986769 
FANCCFA3 | FAC | FACC | FLJ14675Fanconi anemia, complementation group C-HPRD,BioGRID10848598 
FRAP1FLJ44809 | FRAP | FRAP2 | MTOR | RAFT1 | RAPT1FK506 binding protein 12-rapamycin associated protein 1Affinity Capture-WesternBioGRID12807916 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1-HPRD,BioGRID11301323 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1RACK-1 interacts with STAT1-beta.BIND12960323 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1RACK-1 interacts with STAT1-alpha.BIND12960323 
GTF2IBAP-135 | BAP135 | BTKAP1 | DIWS | FLJ38776 | FLJ56355 | IB291 | SPIN | TFII-I | WBS | WBSCR6general transcription factor II, i-HPRD,BioGRID9584171 
HSF1HSTF1heat shock transcription factor 1-HPRD,BioGRID9880553 
IFNAR2IFN-R | IFN-alpha-REC | IFNABR | IFNARBinterferon (alpha, beta and omega) receptor 2Reconstituted ComplexBioGRID9121453 |11301323 
IL27RACRL1 | IL27R | TCCR | WSX1 | zcytor1interleukin 27 receptor, alpha-HPRD,BioGRID12734330 
IL2RBCD122 | P70-75interleukin 2 receptor, beta-HPRD,BioGRID10602027 
IL2RGCD132 | IMD4 | SCIDX | SCIDX1interleukin 2 receptor, gamma (severe combined immunodeficiency)-HPRD11418623 
IRF1IRF-1 | MARinterferon regulatory factor 1-HPRD,BioGRID10764778 
IRF9IRF-9 | ISGF3 | ISGF3G | p48interferon regulatory factor 9-HPRD,BioGRID8943351 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)-HPRD11722592 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID10490649 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homologSTAT1-alpha interacts with c-kitBIND9355737 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog-HPRD,BioGRID9355737 
KPNA1IPOA5 | NPI-1 | RCH2 | SRP1karyopherin alpha 1 (importin alpha 5)-HPRD,BioGRID12048190 
KPNA2IPOA1 | QIP2 | RCH1 | SRP1alphakaryopherin alpha 2 (RAG cohort 1, importin alpha 1)An unspecified isoform of STAT1 interacts with karyopherin alpha (K-alpha).BIND10964507 
LMO2RBTN2 | RBTNL1 | RHOM2 | TTG2LIM domain only 2 (rhombotin-like 1)Two-hybridBioGRID16189514 
MCM3HCC5 | MGC1157 | P1-MCM3 | P1.h | RLFBminichromosome maintenance complex component 3-HPRD11248027 
MCM5CDC46 | MGC5315 | P1-CDC46minichromosome maintenance complex component 5-HPRD,BioGRID9843502 |11248027 
MDKFLJ27379 | MK | NEGF2midkine (neurite growth-promoting factor 2)-HPRD9452495 
NMI-N-myc (and STAT) interactor-HPRD,BioGRID9989503 
NMI-N-myc (and STAT) interactorNmi interacts with Stat1BIND9989503 
PIAS1DDXBP1 | GBP | GU/RH-II | MGC141878 | MGC141879 | ZMIZ3protein inhibitor of activated STAT, 1-HPRD,BioGRID9724754 |10805787 
|12855578|10805787 
PIAS1DDXBP1 | GBP | GU/RH-II | MGC141878 | MGC141879 | ZMIZ3protein inhibitor of activated STAT, 1-HPRD9724754 |10805787 
|12855578 
PRKCDMAY1 | MGC49908 | PKCD | nPKC-deltaprotein kinase C, deltaAffinity Capture-WesternBioGRID12807916 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD,BioGRID11278462 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID9344858 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDa-HPRD,BioGRID9630226 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDaStat1-alpha interacts with Stat1-alpha. This interaction was modelled on a demonstrated interaction between Stat1-alpha and Stat1-alpha both from an unspecified species.BIND8986769 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDaStat1 interacts with itself to form a dimer.BIND15780933 
STAT2ISGF-3 | MGC59816 | P113 | STAT113signal transducer and activator of transcription 2, 113kDaSTAT1 interacts with STAT2.BIND15467722 
STAT2ISGF-3 | MGC59816 | P113 | STAT113signal transducer and activator of transcription 2, 113kDa-HPRD,BioGRID8621447 |10446176 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID12070153 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinaseSyk interacts with and phosphorylates STAT1-alpha.BIND15467722 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinaseSyk interacts with STAT1-beta.BIND15467722 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1A-HPRD,BioGRID10848577 
TNFRSF1BCD120b | TBPII | TNF-R-II | TNF-R75 | TNFBR | TNFR1B | TNFR2 | TNFR80 | p75 | p75TNFRtumor necrosis factor receptor superfamily, member 1B-HPRD10848577 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domain-HPRD,BioGRID10848577 
TYK2JTK1tyrosine kinase 2Biochemical ActivityBioGRID12960323 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)-HPRD12356736 
VDRNR1I1vitamin D (1,25- dihydroxyvitamin D3) receptor-HPRD,BioGRID11909970 
XPO1CRM1 | DKFZp686B1823exportin 1 (CRM1 homolog, yeast)-HPRD9205132 
ZNF467EZI | Zfp467zinc finger protein 467-HPRD12426389 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 10288All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155105All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION 7256All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 7056All SZGR 2.0 genes in this pathway
BIOCARTA CHEMICAL PATHWAY 2215All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY 4535All SZGR 2.0 genes in this pathway
BIOCARTA EGF PATHWAY 3125All SZGR 2.0 genes in this pathway
BIOCARTA IL10 PATHWAY 1714All SZGR 2.0 genes in this pathway
BIOCARTA IL22BP PATHWAY 1612All SZGR 2.0 genes in this pathway
BIOCARTA GLEEVEC PATHWAY 2317All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 8768All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY 4031All SZGR 2.0 genes in this pathway
BIOCARTA PDGF PATHWAY 3225All SZGR 2.0 genes in this pathway
BIOCARTA TPO PATHWAY 2417All SZGR 2.0 genes in this pathway
ST INTERFERON GAMMA PATHWAY 107All SZGR 2.0 genes in this pathway
ST TYPE I INTERFERON PATHWAY 98All SZGR 2.0 genes in this pathway
PID GMCSF PATHWAY 3731All SZGR 2.0 genes in this pathway
PID IL27 PATHWAY 2620All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY 6354All SZGR 2.0 genes in this pathway
PID TCPTP PATHWAY 4333All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY 5846All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY 8260All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY 5543All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 10278All SZGR 2.0 genes in this pathway
PID ERBB1 RECEPTOR PROXIMAL PATHWAY 3529All SZGR 2.0 genes in this pathway
PID TNF PATHWAY 4633All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY 4034All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 10578All SZGR 2.0 genes in this pathway
PID IL6 7 PATHWAY 4740All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129103All SZGR 2.0 genes in this pathway
PID IL23 PATHWAY 3730All SZGR 2.0 genes in this pathway
PID KIT PATHWAY 5240All SZGR 2.0 genes in this pathway
PID EPO PATHWAY 3429All SZGR 2.0 genes in this pathway
PID FGF PATHWAY 5537All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT 7859All SZGR 2.0 genes in this pathway
REACTOME GROWTH HORMONE RECEPTOR SIGNALING 2419All SZGR 2.0 genes in this pathway
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 6645All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE 12788All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR1 MUTANTS 3020All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR1 FUSION MUTANTS 1912All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR MUTANTS 4429All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 12293All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 9576All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 10786All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF IFNG SIGNALING 1410All SZGR 2.0 genes in this pathway
REACTOME INTERFERON GAMMA SIGNALING 6348All SZGR 2.0 genes in this pathway
REACTOME INTERFERON ALPHA BETA SIGNALING 6450All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF IFNA SIGNALING 2422All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING 159116All SZGR 2.0 genes in this pathway
REACTOME IL 6 SIGNALING 119All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN 267178All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206111All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294178All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
SAMOLS TARGETS OF KHSV MIRNAS DN 6235All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS DN 2518All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN 186114All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS GREY DN 7444All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182110All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 15791All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP 175108All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157104All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM UP 9858All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES UP 1915All SZGR 2.0 genes in this pathway
YEMELYANOV GR TARGETS DN 108All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
CASTELLANO NRAS TARGETS UP 6841All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215137All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211136All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP 12678All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
NUNODA RESPONSE TO DASATINIB IMATINIB DN 1310All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 7751All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 TTD UP 6439All SZGR 2.0 genes in this pathway
SEIDEN ONCOGENESIS BY MET 8853All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178108All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
PATTERSON DOCETAXEL RESISTANCE 2920All SZGR 2.0 genes in this pathway
BOWIE RESPONSE TO EXTRACELLULAR MATRIX 1711All SZGR 2.0 genes in this pathway
BOWIE RESPONSE TO TAMOXIFEN 1810All SZGR 2.0 genes in this pathway
EINAV INTERFERON SIGNATURE IN CANCER 2716All SZGR 2.0 genes in this pathway
DAUER STAT3 TARGETS DN 5034All SZGR 2.0 genes in this pathway
MEINHOLD OVARIAN CANCER LOW GRADE DN 2016All SZGR 2.0 genes in this pathway
YAN ESCAPE FROM ANOIKIS 2419All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP 11071All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149101All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS UP 4738All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE UP 7760All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED 10068All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN 3624All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 8 3628All SZGR 2.0 genes in this pathway
SHIPP DLBCL CURED VS FATAL DN 4530All SZGR 2.0 genes in this pathway
GRANDVAUX IFN RESPONSE NOT VIA IRF3 1410All SZGR 2.0 genes in this pathway
KIM GERMINAL CENTER T HELPER UP 6642All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP 7151All SZGR 2.0 genes in this pathway
DER IFN ALPHA RESPONSE UP 7448All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER PROGRESSION G1 G2 UP 129All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP 5240All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP 8758All SZGR 2.0 genes in this pathway
WIELAND UP BY HBV INFECTION 10166All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP 10267All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6 14498All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS 6648All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176122All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
DER IFN GAMMA RESPONSE UP 7145All SZGR 2.0 genes in this pathway
XU RESPONSE TO TRETINOIN AND NSC682994 UP 1713All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS UP 8864All SZGR 2.0 genes in this pathway
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS 3121All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP 10176All SZGR 2.0 genes in this pathway
LIANG SILENCED BY METHYLATION 2 5334All SZGR 2.0 genes in this pathway
TRAYNOR RETT SYNDROM UP 4533All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP 7149All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TROGLITAZONE UP 2515All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF UP 1210All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
CHANG IMMORTALIZED BY HPV31 DN 6545All SZGR 2.0 genes in this pathway
BROWNE INTERFERON RESPONSIVE GENES 6844All SZGR 2.0 genes in this pathway
KRASNOSELSKAYA ILF3 TARGETS UP 3824All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN 228146All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA 5031All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF TROGLITAZONE UP 1711All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN UP 3021All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198132All SZGR 2.0 genes in this pathway
LIANG SILENCED BY METHYLATION UP 3218All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C5 4636All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A UP 8152All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS UP 4940All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314188All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373196All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T7 9863All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220147All SZGR 2.0 genes in this pathway
NIKOLSKY OVERCONNECTED IN BREAST CANCER 2219All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 15692All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER PROGRESSION UP 2014All SZGR 2.0 genes in this pathway
MOSERLE IFNA RESPONSE 3119All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP 10767All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP 13179All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A 6752All SZGR 2.0 genes in this pathway
NUTT GBM VS AO GLIOMA UP 4634All SZGR 2.0 genes in this pathway
ZHANG INTERFERON RESPONSE 2314All SZGR 2.0 genes in this pathway
WUNDER INFLAMMATORY RESPONSE AND CHOLESTEROL UP 5838All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315201All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408276All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS UP 8961All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP 181106All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G5 DN 2717All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS INTERFERON UP 2610All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE UP 6242All SZGR 2.0 genes in this pathway
TSAI DNAJB4 TARGETS UP 138All SZGR 2.0 genes in this pathway
UROSEVIC RESPONSE TO IMIQUIMOD 2314All SZGR 2.0 genes in this pathway
HAHTOLA CTCL CUTANEOUS 2619All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA LB DN 4423All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS DN 8766All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN 8868All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 182102All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 DN 5024All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 403240All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244157All SZGR 2.0 genes in this pathway
KRIEG KDM3A TARGETS NOT HYPOXIA 208107All SZGR 2.0 genes in this pathway
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION 12881All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297194All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS 9554All SZGR 2.0 genes in this pathway