Gene Page: SVIL

Summary
GeneID  6840
Symbol  SVIL
Synonyms  DKFZp686A17191
Description  supervillin
See related  HGNC:11480|MIM:604126|Ensembl:ENSG00000197321|HPRD:04992|
Locus tag  RP11-534G20.1
Gene type  protein-coding
Map location  10p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
COPS30.880.88
C1QBP0.880.86
MYL12B0.880.87
MAGEH10.880.87
PSMD130.880.88
FARSB0.880.87
C4orf270.870.90
CDC420.870.89
UQCRC20.870.83
ARPC20.870.84
Top 10 negatively co-expressed genes
AF347015.26-0.73-0.74
AF347015.2-0.72-0.72
AF347015.33-0.71-0.71
AF347015.8-0.71-0.69
MT-CO2-0.71-0.67
MT-CYB-0.71-0.70
AF347015.15-0.69-0.69
AF347015.27-0.68-0.67
AF347015.31-0.66-0.65
AF347015.9-0.65-0.67
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingIEA-
GO:0051015actin filament bindingIDA12711699 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007519skeletal muscle developmentIMPneuron (GO term level: 8)12711699 
GO:0007010cytoskeleton organizationIEA-
GO:0051016barbed-end actin filament cappingIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA12711699 
GO:0005737cytoplasmIDA12711699 
GO:0005886plasma membraneIDA12711699 
GO:0015629actin cytoskeletonNAS9867483 
GO:0043034costamereIDA12711699 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID11792840 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1Two-hybridBioGRID11792840 
LUC7L2CGI-59 | CGI-74 | FLJ10657 | LUC7B2LUC7-like 2 (S. cerevisiae)Two-hybridBioGRID16169070 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)Two-hybridBioGRID11792840 
P2RX7MGC20089 | P2X7purinergic receptor P2X, ligand-gated ion channel, 7-HPRD11707406 
PPARGNR1C3 | PPARG1 | PPARG2 | PPARgammaperoxisome proliferator-activated receptor gammaTwo-hybridBioGRID11792840 
TGFB1I1ARA55 | HIC-5 | HIC5 | TSC-5transforming growth factor beta 1 induced transcript 1-HPRD11792840 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_AR_PATHWAY 6146All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
LAIHO_COLORECTAL_CANCER_SERRATED_UP 11271All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN 12686All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN 162116All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN 9557All SZGR genes in this pathway
GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP 6647All SZGR genes in this pathway
COLDREN_GEFITINIB_RESISTANCE_DN 230115All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
KANG_GIST_WITH_PDGFRA_DN 55All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
TOMLINS_PROSTATE_CANCER_DN 4033All SZGR genes in this pathway
GARCIA_TARGETS_OF_FLI1_AND_DAX1_UP 5734All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX5_UP 117All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
KIM_GERMINAL_CENTER_T_HELPER_DN 2415All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_DN 10267All SZGR genes in this pathway
CROMER_METASTASIS_DN 8158All SZGR genes in this pathway
TRAYNOR_RETT_SYNDROM_UP 4533All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_DN 8662All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRACX_DN 2014All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_DN 10170All SZGR genes in this pathway
NIELSEN_LEIOMYOSARCOMA_CNN1_UP 1913All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_DN 4531All SZGR genes in this pathway
QI_PLASMACYTOMA_DN 10063All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_DN 13899All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP 229149All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP 211131All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP 281183All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN 229135All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN 321200All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
ALFANO_MYC_TARGETS 239156All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/506692698m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-141/200a3423481Ahsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-142-5p3343401Ahsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-295935991Ahsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-4103853911Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
hsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-493-5p705711m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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