Gene Page: TRPC6

Summary ?
GeneID7225
SymbolTRPC6
SynonymsFSGS2|TRP6
Descriptiontransient receptor potential cation channel subfamily C member 6
ReferenceMIM:603652|HGNC:HGNC:12338|Ensembl:ENSG00000137672|HPRD:04710|Vega:OTTHUMG00000167483
Gene typeprotein-coding
Map location11q22.1
Pascal p-value0.619
Fetal beta-0.421

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CSTF10.900.90
RNF340.900.89
PRPF40.890.90
SMU10.890.89
WBP110.890.87
KIAA04060.890.91
SLBP0.890.86
SLC30A50.880.87
EFTUD20.880.89
GORASP20.880.87
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.84-0.84
AF347015.31-0.81-0.82
AF347015.21-0.81-0.85
AF347015.8-0.81-0.83
MT-CYB-0.80-0.81
AF347015.33-0.80-0.81
AF347015.27-0.79-0.81
AF347015.2-0.77-0.79
AF347015.15-0.76-0.81
FXYD1-0.75-0.79

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID14761972 
ITPR1INSP3R1 | IP3R | IP3R1 | SCA15 | SCA16inositol 1,4,5-triphosphate receptor, type 1Affinity Capture-WesternBioGRID14505576 
ITPR3FLJ36205 | IP3R | IP3R3inositol 1,4,5-triphosphate receptor, type 3-HPRD,BioGRID11290752 
MX1IFI-78K | IFI78 | MX | MxAmyxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)MxA interacts with TRPC6.BIND15757897 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID14761972 
TRPC1HTRP-1 | MGC133334 | MGC133335 | TRP1transient receptor potential cation channel, subfamily C, member 1Affinity Capture-WesternBioGRID12857742 
TRPC2-transient receptor potential cation channel, subfamily C, member 2 (pseudogene)Affinity Capture-WesternBioGRID14699131 
TRPC3TRP3transient receptor potential cation channel, subfamily C, member 3-HPRD,BioGRID12032305 
TRPC3TRP3transient receptor potential cation channel, subfamily C, member 3-HPRD15623527 
TRPC4HTRP4 | MGC119570 | MGC119571 | MGC119572 | MGC119573 | TRP4transient receptor potential cation channel, subfamily C, member 4Affinity Capture-WesternBioGRID12857742 
TRPC5TRP5transient receptor potential cation channel, subfamily C, member 5Affinity Capture-WesternBioGRID12857742 
TRPC6FLJ11098 | FLJ14863 | FSGS2 | TRP6transient receptor potential cation channel, subfamily C, member 6-HPRD,BioGRID12032305 
TRPC7TRP7transient receptor potential cation channel, subfamily C, member 7FRETBioGRID12032305 
TRPM2EREG1 | KNP3 | LTRPC2 | MGC133383 | NUDT9H | NUDT9L1 | TRPC7transient receptor potential cation channel, subfamily M, member 2-HPRD12032305 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID ENDOTHELIN PATHWAY 6352All SZGR 2.0 genes in this pathway
PID NEPHRIN NEPH1 PATHWAY 3124All SZGR 2.0 genes in this pathway
PID EPO PATHWAY 3429All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY 4332All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205136All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS 106All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251188All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184116All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME EFFECTS OF PIP2 HYDROLYSIS 2517All SZGR 2.0 genes in this pathway
REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING 118All SZGR 2.0 genes in this pathway
REACTOME NETRIN1 SIGNALING 4130All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS 7849All SZGR 2.0 genes in this pathway
REACTOME PLATELET CALCIUM HOMEOSTASIS 1810All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN 384230All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN 185115All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162104All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN 180110All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN 181107All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA PROGRESSION RISK 7444All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH VS LOW DN 3221All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229137All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS 191131All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246152All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway