SZGR2

Summary ?

GeneID	7280
Symbol	TUBB2A
Synonyms	CDCBM5\|TUBB\|TUBB2
Description	tubulin beta 2A class IIa
Reference	MIM:615101\|HGNC:HGNC:12412\|Ensembl:ENSG00000137267\|HPRD:01852\|Vega:OTTHUMG00000014135
Gene type	protein-coding
Map location	6p25
Pascal p-value	0.005
Sherlock p-value	0.886
Fetal beta	0.041
Support	STRUCTURAL PLASTICITY G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.0159
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
UBE2N	0.93	0.91
TMED2	0.91	0.91
STRAP	0.91	0.89
ARMC1	0.91	0.90
CNOT7	0.91	0.90
PTGES3	0.90	0.88
AZIN1	0.90	0.89
TIPRL	0.90	0.89
ABCE1	0.90	0.89
COPS3	0.90	0.86

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.71	-0.70
AF347015.2	-0.68	-0.69
MT-CYB	-0.68	-0.69
AF347015.26	-0.68	-0.69
AF347015.8	-0.67	-0.69
AF347015.33	-0.67	-0.68
AF347015.31	-0.67	-0.67
FXYD1	-0.65	-0.71
HIGD1B	-0.65	-0.68
GPT	-0.64	-0.69

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0003924	GTPase activity	IEA		-
GO:0005515	protein binding	IPI		17373842
GO:0005525	GTP binding	IEA		-
GO:0005198	structural molecule activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007018	microtubule-based movement	IEA		-
GO:0051258	protein polymerization	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005874	microtubule	IEA		-
GO:0005737	cytoplasm	IEA		-
GO:0043234	protein complex	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ALDOA	ALDA \| MGC10942 \| MGC17716 \| MGC17767	aldolase A, fructose-bisphosphate	-	HPRD	8103323
ARL15	ARFRP2 \| FLJ20051	ADP-ribosylation factor-like 15	Two-hybrid	BioGRID	16169070
ARL8B	ARL10C \| FLJ10702 \| Gie1	ADP-ribosylation factor-like 8B	-	HPRD	15331635
C20orf20	Eaf7 \| FLJ10914 \| MRG15BP \| MRGBP \| URCC4	chromosome 20 open reading frame 20	-	HPRD	12963728
CHGB	SCG1	chromogranin B (secretogranin 1)	Two-hybrid	BioGRID	16169070
CRIPT	HSPC139	cysteine-rich PDZ-binding protein	-	HPRD	9581762
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	-	HPRD	12884273
GRM1	GPRC1A \| GRM1A \| MGLUR1 \| MGLUR1A \| mGlu1	glutamate receptor, metabotropic 1	-	HPRD	9886087
LAMA4	DKFZp686D23145 \| LAMA3 \| LAMA4*-1	laminin, alpha 4	Two-hybrid	BioGRID	16169070
MAP1A	FLJ77111 \| MAP1L \| MTAP1A	microtubule-associated protein 1A	-	HPRD	11278895
MAP3K10	MLK2 \| MST	mitogen-activated protein kinase kinase kinase 10	-	HPRD	9629920
MAP3K7	TAK1 \| TGF1a	mitogen-activated protein kinase kinase kinase 7	-	HPRD	14743216
MAP4	DKFZp779A1753 \| MGC8617	microtubule-associated protein 4	-	HPRD	12855424
MAP6	FLJ41346 \| KIAA1878 \| MTAP6 \| N-STOP \| STOP	microtubule-associated protein 6	-	HPRD	8700896
MAPT	DDPAC \| FLJ31424 \| FTDP-17 \| MAPTL \| MGC138549 \| MSTD \| MTBT1 \| MTBT2 \| PPND \| TAU	microtubule-associated protein tau	-	HPRD	9922135
MARK4	FLJ90097 \| KIAA1860 \| MARKL1 \| Nbla00650	MAP/microtubule affinity-regulating kinase 4	-	HPRD	14594945
MX1	IFI-78K \| IFI78 \| MX \| MxA	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	-	HPRD	1629950
NCALD	MGC33870 \| MGC74858	neurocalcin delta	-	HPRD	11964161
NPHP1	FLJ97602 \| JBTS4 \| NPH1 \| SLSN1	nephronophthisis 1 (juvenile)	-	HPRD	12872123
PAFAH1B3	-	platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa	Two-hybrid	BioGRID	16169070
PIGT	CGI-06 \| FLJ41596 \| MGC8909 \| NDAP	phosphatidylinositol glycan anchor biosynthesis, class T	-	HPRD	12052837
PSMD11	MGC3844 \| Rpn6 \| S9 \| p44.5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	Two-hybrid	BioGRID	16169070
PTPRS	PTPSIGMA	protein tyrosine phosphatase, receptor type, S	Two-hybrid	BioGRID	16169070
RAB8B	FLJ38125	RAB8B, member RAS oncogene family	-	HPRD	12639940
RABAC1	PRA1 \| PRAF1 \| YIP3	Rab acceptor 1 (prenylated)	Two-hybrid	BioGRID	16169070
RASSF1	123F2 \| NORE2A \| RASSF1A \| RDA32 \| REH3P21	Ras association (RalGDS/AF-6) domain family member 1	-	HPRD	14603253
RIC8A	MGC104517 \| MGC131931 \| MGC148073 \| MGC148074 \| RIC8 \| synembryn	resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	Two-hybrid	BioGRID	16169070
RPA2	REPA2 \| RPA32	replication protein A2, 32kDa	Two-hybrid	BioGRID	16169070
RPLP1	FLJ27448 \| MGC5215 \| P1 \| RPP1	ribosomal protein, large, P1	Two-hybrid	BioGRID	16169070
SAT1	DC21 \| KFSD \| SAT \| SSAT \| SSAT-1	spermidine/spermine N1-acetyltransferase 1	Two-hybrid	BioGRID	16169070
SDC3	N-syndecan \| SDCN \| SYND3	syndecan 3	-	HPRD,BioGRID	9553134
SERPINB9	CAP-3 \| CAP3 \| PI9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	Two-hybrid	BioGRID	16169070
STXBP1	EIEE4 \| MUNC18-1 \| UNC18 \| hUNC18 \| rbSec1	syntaxin binding protein 1	Affinity Capture-Western	BioGRID	12963086
SYT9	FLJ45896	synaptotagmin IX	-	HPRD	12966166
TAOK2	KIAA0881 \| MAP3K17 \| PSK \| PSK1 \| TAO1 \| TAO2	TAO kinase 2	-	HPRD	12639963
TBCD	KIAA0988	tubulin folding cofactor D	-	HPRD	10722852
TGM2	G-ALPHA-h \| GNAH \| TG2 \| TGC	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	-	HPRD	9973324
TK1	TK2	thymidine kinase 1, soluble	Two-hybrid	BioGRID	16169070
TRADD	Hs.89862 \| MGC11078	TNFRSF1A-associated via death domain	-	HPRD	14743216

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG GAP JUNCTION	90	68	All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION	59	36	All SZGR 2.0 genes in this pathway
PID HDAC CLASSII PATHWAY	34	27	All SZGR 2.0 genes in this pathway
PID HDAC CLASSIII PATHWAY	25	20	All SZGR 2.0 genes in this pathway
REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	28	15	All SZGR 2.0 genes in this pathway
REACTOME PROTEIN FOLDING	53	30	All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	22	11	All SZGR 2.0 genes in this pathway
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	19	10	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS	518	242	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP	285	181	All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN	136	86	All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE DN	92	51	All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP	201	125	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA DN	349	157	All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP	183	119	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL DN	50	36	All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN	241	146	All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP	290	177	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP	157	91	All SZGR 2.0 genes in this pathway
HUMMEL BURKITTS LYMPHOMA UP	43	27	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP	176	123	All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN	226	132	All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL QUIESCENT UP	87	45	All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP	57	33	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN	136	94	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN	142	95	All SZGR 2.0 genes in this pathway
CASTELLANO NRAS TARGETS UP	68	41	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2	127	92	All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE LATE UP	57	41	All SZGR 2.0 genes in this pathway
WIEMANN TELOMERE SHORTENING AND CHRONIC LIVER DAMAGE UP	8	5	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2	153	102	All SZGR 2.0 genes in this pathway
COWLING MYCN TARGETS	43	27	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
LIAO METASTASIS	539	324	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP	223	140	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK	169	111	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK UP	63	48	All SZGR 2.0 genes in this pathway
LEI MYB TARGETS	318	215	All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN	234	137	All SZGR 2.0 genes in this pathway
RADMACHER AML PROGNOSIS	78	52	All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP	151	103	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP	249	170	All SZGR 2.0 genes in this pathway
HU GENOTOXIC DAMAGE 24HR	35	22	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP	203	135	All SZGR 2.0 genes in this pathway
MCCLUNG DELTA FOSB TARGETS 2WK	48	36	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP	244	151	All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP	120	89	All SZGR 2.0 genes in this pathway
SARTIPY NORMAL AT INSULIN RESISTANCE UP	34	27	All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN	51	32	All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR UP	93	65	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G1	67	41	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 8HR	39	31	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G2	30	18	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP	566	371	All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS	47	28	All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL UP	45	26	All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP	147	98	All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION C	69	49	All SZGR 2.0 genes in this pathway
RAY TARGETS OF P210 BCR ABL FUSION UP	18	13	All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM LOW RISK DN	30	20	All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING UP	41	24	All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP	181	106	All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN	251	151	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11	103	68	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G24	28	19	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS DN	87	66	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP	90	58	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2	182	102	All SZGR 2.0 genes in this pathway
RAGHAVACHARI PLATELET SPECIFIC GENES	70	46	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT	567	365	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 3 DN	39	21	All SZGR 2.0 genes in this pathway
BILANGES SERUM SENSITIVE GENES	90	54	All SZGR 2.0 genes in this pathway
BILANGES RAPAMYCIN SENSITIVE VIA TSC1 AND TSC2	73	37	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL	160	106	All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP	146	75	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-200bc/429	147	153	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-29	76	82	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: TUBB2A