Gene Page: SF1

Summary ?
GeneID7536
SymbolSF1
SynonymsBBP|D11S636|MBBP|ZCCHC25|ZFM1|ZNF162
Descriptionsplicing factor 1
ReferenceMIM:601516|HGNC:HGNC:12950|Ensembl:ENSG00000168066|HPRD:03306|Vega:OTTHUMG00000066833
Gene typeprotein-coding
Map location11q13
Pascal p-value0.422
Fetal beta0.893
DMG1 (# studies)
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg046190461164541730SF12.476E-4-0.6040.037DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6576747chr185530213SF175360.19trans
rs17025528chr1216043152SF175360.1trans
rs12997903chr21952083SF175360.08trans
rs6733654chr21963270SF175360.04trans
rs891877chr22043348SF175360.03trans
rs1395163chr331028951SF175360trans
rs17029291chr332402138SF175361.254E-4trans
rs6446109chr360076988SF175360.07trans
rs624496chr3120506736SF175360.02trans
rs16870339chr52705169SF175360.01trans
rs4617108chr749423831SF175360.13trans
rs17160578chr785672108SF175360.13trans
rs722970chr785803264SF175360.07trans
rs17324099chr785856288SF175360.13trans
snp_a-19046130SF175360.02trans
rs1831517chr92513405SF175360.07trans
rs7864672chr931068069SF175360.03trans
rs11259374chr1014917473SF175360.08trans
rs4607971chr1019407890SF175360.04trans
rs12569493chr1074886042SF175360.07trans
rs16930362chr1074890320SF175360.11trans
rs909288chr10124257417SF175360.12trans
rs11021829chr1111416216SF175360.15trans
rs17133022chr1198980829SF175360.17trans
rs9554597chr13100117238SF175360.17trans
rs10145685chr1422794892SF175360.02trans
rs17793827chr1422797560SF175360.01trans
rs10136383chr1422801078SF175360.01trans
rs2455956chr1443524686SF175360.04trans
rs2254834chr1443596184SF175360.01trans
rs1954396chr1443601835SF175361.31E-4trans
rs9925128chr1679102822SF175360.11trans
rs1761450chr1954818034SF175360.03trans
rs16996418chr209778936SF175360.04trans
rs16996420chr209780867SF175360.01trans
rs12157904chr2237982011SF175360.03trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CHD40.920.92
CRKRS0.910.93
ZNF2640.910.93
LIG30.910.90
ZNF7400.910.90
KDM3B0.910.92
CYTSA0.900.92
GCN1L10.900.90
KPNB10.900.92
ZXDC0.900.90
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.72-0.83
FXYD1-0.70-0.81
IFI27-0.70-0.81
MT-CO2-0.69-0.81
AF347015.27-0.68-0.79
HIGD1B-0.68-0.81
AF347015.33-0.67-0.77
AF347015.21-0.67-0.85
S100B-0.66-0.75
CXCL14-0.66-0.79

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCL2Bcl-2B-cell CLL/lymphoma 2-HPRD,BioGRID8668206 
DDX17DKFZp761H2016 | P72 | RH70DEAD (Asp-Glu-Ala-Asp) box polypeptide 17Two-hybridBioGRID16189514 
EWSR1EWSEwing sarcoma breakpoint region 1-HPRD,BioGRID9660765 
FUSCHOP | FUS-CHOP | FUS1 | TLS | TLS/CHOP | hnRNP-P2fusion (involved in t(12;16) in malignant liposarcoma)-HPRD,BioGRID9660765 
PLSCR1MMTRA1Bphospholipid scramblase 1Two-hybridBioGRID16189514 
PRPF40AFBP-11 | FBP11 | FLAF1 | FLJ20585 | FNBP3 | HIP10 | HYPA | NY-REN-6PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)-HPRD15456888 
RBPMSHERMESRNA binding protein with multiple splicingTwo-hybridBioGRID16189514 
TAF15Npl3 | RBP56 | TAF2N | TAFII68 | hTAFII68TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa-HPRD,BioGRID9660765 
TCERG1CA150 | MGC133200 | TAF2Stranscription elongation regulator 1-HPRD,BioGRID11604498 
TRIM23ARD1 | ARFD1 | RNF46tripartite motif-containing 23Two-hybridBioGRID16189514 
U2AF2U2AF65U2 small nuclear RNA auxiliary factor 2-HPRD,BioGRID9150140 |9512519 
U2AF2U2AF65U2 small nuclear RNA auxiliary factor 2U2AF65 interacts with an unspecified isoform of SF1 (mBBP).BIND9512519 
WWP2AIP2 | WWp2-likeWW domain containing E3 ubiquitin protein ligase 2Two-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN 198110All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP 177110All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA DN 10459All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN 384230All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335193All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180101All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP 214155All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP 11071All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 DN 6638All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160110All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6 14498All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP 151100All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY TBH AND H2O2 3624All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302191All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR UP 11168All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 14896All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463262All SZGR 2.0 genes in this pathway
MATZUK MALE REPRODUCTION SERTOLI 2823All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
MOOTHA PGC 420269All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION 13087All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR 15288All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway