Summary ?
GeneID757
SymbolTMEM50B
SynonymsC21orf4|HCVP7TP3
Descriptiontransmembrane protein 50B
ReferenceHGNC:HGNC:1280|Ensembl:ENSG00000142188|HPRD:10747|Vega:OTTHUMG00000065286
Gene typeprotein-coding
Map location21q22.11
Pascal p-value0.005
Fetal beta0.027
DMG1 (# studies)
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg173567332134774627TMEM50B0.0032.944DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs130502462134841869TMEM50BENSG00000142188.121.429E-60.0310449gtex_brain_ba24
rs782938902134859401TMEM50BENSG00000142188.122.59E-60.03-7083gtex_brain_ba24
rs98086852134785672TMEM50BENSG00000142188.123.062E-6066646gtex_brain_putamen_basal
rs28342102134786574TMEM50BENSG00000142188.123.062E-6065744gtex_brain_putamen_basal
rs72838502134789549TMEM50BENSG00000142188.121.16E-7062769gtex_brain_putamen_basal
rs72778082134789695TMEM50BENSG00000142188.123.048E-6062623gtex_brain_putamen_basal
rs28342142134793706TMEM50BENSG00000142188.123.052E-6058612gtex_brain_putamen_basal
rs713269492134794982TMEM50BENSG00000142188.122.44E-7057336gtex_brain_putamen_basal
rs178859442134796199TMEM50BENSG00000142188.129.381E-8056119gtex_brain_putamen_basal
rs28342152134796886TMEM50BENSG00000142188.123.026E-6055432gtex_brain_putamen_basal
rs178828482134797183TMEM50BENSG00000142188.122.243E-6055135gtex_brain_putamen_basal
rs119106272134799350TMEM50BENSG00000142188.121.164E-7052968gtex_brain_putamen_basal
rs1392581932134800146TMEM50BENSG00000142188.122.245E-8052172gtex_brain_putamen_basal
rs678168612134800150TMEM50BENSG00000142188.121.036E-6052168gtex_brain_putamen_basal
rs81309242134800872TMEM50BENSG00000142188.121.132E-7051446gtex_brain_putamen_basal
rs81320062134802841TMEM50BENSG00000142188.121.053E-7049477gtex_brain_putamen_basal
rs81325352134802946TMEM50BENSG00000142188.123.957E-8049372gtex_brain_putamen_basal
rs15322134804966TMEM50BENSG00000142188.121.046E-7047352gtex_brain_putamen_basal
rs178828222134806091TMEM50BENSG00000142188.121.618E-8046227gtex_brain_putamen_basal
rs22845542134806218TMEM50BENSG00000142188.121.618E-8046100gtex_brain_putamen_basal
rs22845552134806288TMEM50BENSG00000142188.121.622E-8046030gtex_brain_putamen_basal
rs22845562134806305TMEM50BENSG00000142188.121.384E-8046013gtex_brain_putamen_basal
rs24094932134808289TMEM50BENSG00000142188.121.955E-8044029gtex_brain_putamen_basal
rs24094942134808408TMEM50BENSG00000142188.122.024E-8043910gtex_brain_putamen_basal
rs20401202134809049TMEM50BENSG00000142188.124.139E-8043269gtex_brain_putamen_basal
rs10592932134809693TMEM50BENSG00000142188.122.89E-8042625gtex_brain_putamen_basal
rs81319802134810007TMEM50BENSG00000142188.121.245E-7042311gtex_brain_putamen_basal
rs48164522134810330TMEM50BENSG00000142188.122.89E-8041988gtex_brain_putamen_basal
rs48164532134811357TMEM50BENSG00000142188.122.89E-8040961gtex_brain_putamen_basal
rs65171712134811711TMEM50BENSG00000142188.129.491E-8040607gtex_brain_putamen_basal
rs65171722134811835TMEM50BENSG00000142188.125.619E-8040483gtex_brain_putamen_basal
rs48175672134813316TMEM50BENSG00000142188.122.89E-8039002gtex_brain_putamen_basal
rs48175682134813400TMEM50BENSG00000142188.122.89E-8038918gtex_brain_putamen_basal
rs65171732134813562TMEM50BENSG00000142188.122.89E-8038756gtex_brain_putamen_basal
rs717021142134814327TMEM50BENSG00000142188.122.048E-8037991gtex_brain_putamen_basal
rs19722562134815111TMEM50BENSG00000142188.122.89E-8037207gtex_brain_putamen_basal
rs48164552134815794TMEM50BENSG00000142188.122.89E-8036524gtex_brain_putamen_basal
rs72761122134816479TMEM50BENSG00000142188.123.422E-8035839gtex_brain_putamen_basal
rs99812032134816988TMEM50BENSG00000142188.121.232E-7035330gtex_brain_putamen_basal
rs680820762134818296TMEM50BENSG00000142188.122.89E-8034022gtex_brain_putamen_basal
rs99766192134818692TMEM50BENSG00000142188.121.35E-7033626gtex_brain_putamen_basal
rs99764142134819131TMEM50BENSG00000142188.122.89E-8033187gtex_brain_putamen_basal
rs99763562134819201TMEM50BENSG00000142188.129.064E-8033117gtex_brain_putamen_basal
rs72824962134819582TMEM50BENSG00000142188.122.89E-8032736gtex_brain_putamen_basal
rs110882532134820317TMEM50BENSG00000142188.122.89E-8032001gtex_brain_putamen_basal
rs81334862134820803TMEM50BENSG00000142188.121.037E-7031515gtex_brain_putamen_basal
rs81342002134821131TMEM50BENSG00000142188.121.944E-8031187gtex_brain_putamen_basal
rs28342162134821372TMEM50BENSG00000142188.124.897E-8030946gtex_brain_putamen_basal
rs10442182134821570TMEM50BENSG00000142188.121.944E-8030748gtex_brain_putamen_basal
rs10442132134821691TMEM50BENSG00000142188.121.944E-8030627gtex_brain_putamen_basal
rs28342172134822150TMEM50BENSG00000142188.121.121E-8030168gtex_brain_putamen_basal
rs28342182134822452TMEM50BENSG00000142188.124.897E-8029866gtex_brain_putamen_basal
rs713222112134822493TMEM50BENSG00000142188.124.897E-8029825gtex_brain_putamen_basal
rs606651142134822508TMEM50BENSG00000142188.128.831E-8029810gtex_brain_putamen_basal
rs110882542134822582TMEM50BENSG00000142188.124.897E-8029736gtex_brain_putamen_basal
rs99837402134822629TMEM50BENSG00000142188.121.034E-6029689gtex_brain_putamen_basal
rs31838522134822636TMEM50BENSG00000142188.122.155E-8029682gtex_brain_putamen_basal
rs28342202134823252TMEM50BENSG00000142188.122.89E-8029066gtex_brain_putamen_basal
rs48175712134823663TMEM50BENSG00000142188.121.944E-8028655gtex_brain_putamen_basal
rs614221352134824151TMEM50BENSG00000142188.121.944E-8028167gtex_brain_putamen_basal
rs9287392134824203TMEM50BENSG00000142188.121.944E-8028115gtex_brain_putamen_basal
rs28342212134824478TMEM50BENSG00000142188.121.944E-8027840gtex_brain_putamen_basal
rs28342222134824771TMEM50BENSG00000142188.122.89E-8027547gtex_brain_putamen_basal
rs28342232134825147TMEM50BENSG00000142188.121.944E-8027171gtex_brain_putamen_basal
rs28342242134825318TMEM50BENSG00000142188.121.944E-8027000gtex_brain_putamen_basal
rs44810722134825466TMEM50BENSG00000142188.121.944E-8026852gtex_brain_putamen_basal
rs43009272134825721TMEM50BENSG00000142188.121.944E-8026597gtex_brain_putamen_basal
rs28342252134825875TMEM50BENSG00000142188.121.944E-8026443gtex_brain_putamen_basal
rs93055292134826700TMEM50BENSG00000142188.128.437E-8025618gtex_brain_putamen_basal
rs101542482134827112TMEM50BENSG00000142188.121.944E-8025206gtex_brain_putamen_basal
rs99740842134827421TMEM50BENSG00000142188.124.897E-8024897gtex_brain_putamen_basal
rs37877052134828637TMEM50BENSG00000142188.121.953E-8023681gtex_brain_putamen_basal
rs585250922134829287TMEM50BENSG00000142188.121.953E-8023031gtex_brain_putamen_basal
rs568845762134829419TMEM50BENSG00000142188.121.524E-7022899gtex_brain_putamen_basal
rs28500242134830968TMEM50BENSG00000142188.121.944E-8021350gtex_brain_putamen_basal
rs28342272134832170TMEM50BENSG00000142188.121.944E-8020148gtex_brain_putamen_basal
rs2010684712134832984TMEM50BENSG00000142188.121.948E-8019334gtex_brain_putamen_basal
rs22455732134832985TMEM50BENSG00000142188.121.944E-8019333gtex_brain_putamen_basal
rs22483402134833123TMEM50BENSG00000142188.121.944E-8019195gtex_brain_putamen_basal
rs22483552134833329TMEM50BENSG00000142188.124.895E-8018989gtex_brain_putamen_basal
rs28342292134834727TMEM50BENSG00000142188.121.944E-8017591gtex_brain_putamen_basal
rs130491222134834957TMEM50BENSG00000142188.121.944E-8017361gtex_brain_putamen_basal
rs72834592134835594TMEM50BENSG00000142188.121.944E-8016724gtex_brain_putamen_basal
rs72780562134835774TMEM50BENSG00000142188.121.944E-8016544gtex_brain_putamen_basal
rs130461852134836091TMEM50BENSG00000142188.124.895E-8016227gtex_brain_putamen_basal
rs28342302134836319TMEM50BENSG00000142188.121.944E-8015999gtex_brain_putamen_basal
rs21862802134837144TMEM50BENSG00000142188.121.902E-8015174gtex_brain_putamen_basal
rs22488202134837623TMEM50BENSG00000142188.121.944E-8014695gtex_brain_putamen_basal
rs681499652134838167TMEM50BENSG00000142188.121.944E-8014151gtex_brain_putamen_basal
rs24718412134838339TMEM50BENSG00000142188.121.953E-8013979gtex_brain_putamen_basal
rs28500282134838589TMEM50BENSG00000142188.121.944E-8013729gtex_brain_putamen_basal
rs7433342134839533TMEM50BENSG00000142188.121.944E-8012785gtex_brain_putamen_basal
rs130492782134839756TMEM50BENSG00000142188.124.895E-8012562gtex_brain_putamen_basal
rs713222152134840448TMEM50BENSG00000142188.122.572E-7011870gtex_brain_putamen_basal
rs58436082134840554TMEM50BENSG00000142188.123.073E-8011764gtex_brain_putamen_basal
rs130502462134841869TMEM50BENSG00000142188.125.577E-9010449gtex_brain_putamen_basal
rs130511612134842311TMEM50BENSG00000142188.121.944E-8010007gtex_brain_putamen_basal
rs130472702134842725TMEM50BENSG00000142188.121.947E-809593gtex_brain_putamen_basal
rs130474462134843014TMEM50BENSG00000142188.121.939E-809304gtex_brain_putamen_basal
rs130473522134843055TMEM50BENSG00000142188.121.939E-809263gtex_brain_putamen_basal
rs130519012134844457TMEM50BENSG00000142188.123.893E-907861gtex_brain_putamen_basal
rs353304412134844874TMEM50BENSG00000142188.125.487E-807444gtex_brain_putamen_basal
rs713222172134845466TMEM50BENSG00000142188.121.176E-706852gtex_brain_putamen_basal
rs72777512134845614TMEM50BENSG00000142188.126.222E-806704gtex_brain_putamen_basal
rs72779052134845708TMEM50BENSG00000142188.122.366E-806610gtex_brain_putamen_basal
rs1468860322134846540TMEM50BENSG00000142188.124.883E-805778gtex_brain_putamen_basal
rs130494392134846997TMEM50BENSG00000142188.121.776E-605321gtex_brain_putamen_basal
rs28439742134848517TMEM50BENSG00000142188.124.883E-803801gtex_brain_putamen_basal
rs28437222134848995TMEM50BENSG00000142188.121.939E-803323gtex_brain_putamen_basal
rs27347272134850004TMEM50BENSG00000142188.125.138E-702314gtex_brain_putamen_basal
rs22116882134850744TMEM50BENSG00000142188.121.545E-701574gtex_brain_putamen_basal
rs65171752134857840TMEM50BENSG00000142188.129.307E-70-5522gtex_brain_putamen_basal
rs782938902134859401TMEM50BENSG00000142188.129.964E-70-7083gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
IQGAP20.790.34
PDPN0.730.54
AC093251.10.710.30
TNC0.700.27
CDO10.680.43
PALLD0.670.49
MRC20.660.44
PLCE10.660.42
PLS30.660.35
ZHX20.660.39
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.23-0.20
AF347015.31-0.23-0.21
AF347015.8-0.23-0.22
MT-CYB-0.23-0.22
AF347015.27-0.22-0.21
AF347015.2-0.22-0.19
AF347015.33-0.22-0.21
AF347015.21-0.22-0.23
AF347015.15-0.21-0.20
AF347015.26-0.21-0.18

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372227All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS YELLOW DN 2315All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE DN 6135All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN 14694All SZGR 2.0 genes in this pathway
BIDUS METASTASIS DN 16193All SZGR 2.0 genes in this pathway
MAYBURD RESPONSE TO L663536 DN 5632All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537339All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP 8157All SZGR 2.0 genes in this pathway
TERAMOTO OPN TARGETS CLUSTER 1 1310All SZGR 2.0 genes in this pathway
TOMLINS METASTASIS DN 2016All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE DN 7749All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE UP 5335All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU DN 8369All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544307All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D 7962All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482296All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578341All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198128All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293203All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT UP 166105All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784464All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337236All SZGR 2.0 genes in this pathway