SZGR2

Summary ?

GeneID	7707
Symbol	ZNF148
Synonyms	BERF-1\|BFCOL1\|HT-BETA\|ZBP-89\|ZFP148\|pHZ-52
Description	zinc finger protein 148
Reference	MIM:601897\|HGNC:HGNC:12933\|Ensembl:ENSG00000163848\|HPRD:03540\|Vega:OTTHUMG00000159448
Gene type	protein-coding
Map location	3q21
Pascal p-value	0.005
Sherlock p-value	0.501
eGene	Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
Expression	Meta-analysis of gene expression	P value: 1.378

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003676	nucleic acid binding	IEA		-
GO:0003677	DNA binding	IEA		-
GO:0003704	specific RNA polymerase II transcription factor activity	TAS		9685330
GO:0008270	zinc ion binding	IEA		-
GO:0016563	transcription activator activity	TAS		8355710
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS		9685330
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006355	regulation of transcription, DNA-dependent	TAS		8355710
GO:0006350	transcription	IEA		-
GO:0006968	cellular defense response	TAS		8355710
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005794	Golgi apparatus	IDA		18029348
GO:0005622	intracellular	IEA		-
GO:0005634	nucleus	IEA		-
GO:0005634	nucleus	TAS		8355710
GO:0005665	DNA-directed RNA polymerase II, core complex	TAS		8355710
GO:0005730	nucleolus	IDA		18029348

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN	244	147	All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP	269	146	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP	404	246	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP	119	66	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR DN	209	122	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN	378	231	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP	329	196	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC	108	74	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGG VS IGA DN	26	16	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN	51	35	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR UP	78	56	All SZGR 2.0 genes in this pathway
PARK HSC AND MULTIPOTENT PROGENITORS	50	33	All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO BUTYRATE CURCUMIN SULINDAC TSA 8	16	7	All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS DN	61	47	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS DN	64	44	All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP	198	132	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN	318	220	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C5	46	36	All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH UP	74	56	All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN	220	147	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN	274	165	All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP	425	253	All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE	200	115	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN	185	116	All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP	221	135	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR DN	36	19	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4	227	149	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	825	831	m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
				hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-101	4406	4412	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-124.1	184	190	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	184	190	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	184	190	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-125/351	3311	3317	1A	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	3311	3317	1A	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-128	2446	2452	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	2446	2452	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-130/301	388	394	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-136	72	78	m8	hsa-miR-136	ACUCCAUUUGUUUUGAUGAUGGA
miR-137	3802	3809	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-138	2203	2210	1A,m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-139	816	822	1A	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-140	505	511	m8	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-141/200a	4929	4935	1A	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	4929	4935	1A	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-142-5p	1316	1322	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-143	1004	1010	m8	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-144	4405	4412	1A,m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
				hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
				hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-146	1727	1733	1A	hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
miR-146	1727	1733	1A	hsa-miR-146b^brain	UGAGAACUGAAUUCCAUAGGCU
miR-153	3492	3498	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d	29	36	1A,m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-183	530	536	1A	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-186	2328	2334	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-186	2328	2334	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-196	4140	4146	1A	hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
miR-196	4140	4146	1A	hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
miR-199	4575	4581	m8	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	4575	4581	m8	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-200bc/429	5032	5039	1A,m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-203.1	3858	3865	1A,m8	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
				hsa-miR-203	UGAAAUGUUUAGGACCACUAG
				hsa-miR-203	UGAAAUGUUUAGGACCACUAG
				hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-204/211	1739	1746	1A,m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	1739	1746	1A,m8	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-205	4100	4106	1A	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-208	1356	1362	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-210	289	295	1A	hsa-miR-210	CUGUGCGUGUGACAGCGGCUGA
miR-216	453	459	1A	hsa-miR-216	UAAUCUCAGCUGGCAACUGUG
miR-219	3592	3599	1A,m8	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-221/222	4615	4621	1A	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	4615	4621	1A	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-223	5750	5756	m8	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-23	2221	2227	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	2221	2227	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-24	5684	5690	m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-25/32/92/363/367	3494	3500	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-26	3227	3234	1A,m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
				hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
				hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
				hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-27	2446	2453	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	2446	2453	1A,m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-5p	3960	3967	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-320	1891	1897	m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-323	4528	4534	m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-323	4528	4534	m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-330	4533	4540	1A,m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-346	2347	2353	m8	hsa-miR-346^brain	UGUCUGCCCGCAUGCCUGCCUCU
miR-346	2347	2353	m8	hsa-miR-346^brain	UGUCUGCCCGCAUGCCUGCCUCU
miR-34b	182	188	m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-361	601	607	m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-361	601	607	m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-365	1148	1154	m8	hsa-miR-365	UAAUGCCCCUAAAAAUCCUUAU
miR-370	396	402	m8	hsa-miR-370^brain	GCCUGCUGGGGUGGAACCUGG
miR-377	342	349	1A,m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-378	3841	3847	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-384	3389	3395	1A	hsa-miR-384	AUUCCUAGAAAUUGUUCAUA
miR-410	4523	4529	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-410	4523	4529	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-448	3492	3498	1A	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-493-5p	3741	3748	1A,m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-494	5711	5717	1A	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-499	1356	1362	1A	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-539	948	955	1A,m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-539	948	955	1A,m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-542-3p	4560	4566	m8	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA
miR-543	1334	1340	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-7	3615	3621	m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG
miR-93.hd/291-3p/294/295/302/372/373/520	920	927	1A,m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ZNF148