Gene Page: CACNA1C

Summary
GeneID  775
Symbol  CACNA1C
Synonyms  CACH2|CACN2|CACNL1A1|CCHL1A1|CaV1.2|MGC120730|TS
Description  calcium channel, voltage-dependent, L type, alpha 1C subunit
See related  HGNC:1390|MIM:114205|HPRD:00246|
Locus tag  -
Gene type  protein-coding
Map location  12p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0047 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CYP46A10.800.85
TMEM38A0.750.83
GRASP0.750.81
ADAMTS80.740.76
FBXL160.730.75
STIM10.730.73
STAT60.730.81
DDN0.720.75
PACSIN10.720.79
CTSB0.710.67
Top 10 negatively co-expressed genes
KIAA1949-0.58-0.55
TUBB2B-0.58-0.59
TRAF4-0.56-0.64
ZNF311-0.55-0.56
DYNLT1-0.55-0.70
PPAPDC1B-0.55-0.52
ZNF300-0.55-0.51
RBMX2-0.55-0.69
TIGD1-0.55-0.55
YBX1-0.54-0.57
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingIEA-
GO:0005516calmodulin bindingIPI15140941 
GO:0005244voltage-gated ion channel activityIEA-
GO:0005245voltage-gated calcium channel activityIEA-
GO:0005216ion channel activityIEA-
GO:0015270dihydropyridine-sensitive calcium channel activityIDA8392192 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007204elevation of cytosolic calcium ion concentrationIDA12130699 
GO:0006816calcium ion transportIEA-
GO:0006811ion transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0014069postsynaptic densityIDASynap (GO term level: 10)14140941 
GO:0005737cytoplasmIDA11206130 
GO:0016020membraneIEA-
GO:0016021integral to membraneIDA8392192 
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIDA11206130 
GO:0005891voltage-gated calcium channel complexIDA12130699 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CABP1CALBRAIN | HCALB_BRcalcium binding protein 1-HPRD,BioGRID15140941 
CACNB3CACNLB3calcium channel, voltage-dependent, beta 3 subunit-HPRD,BioGRID15170217 
GNB1-guanine nucleotide binding protein (G protein), beta polypeptide 1Cav1.2 interacts with G-beta-1. This interaction was modeled on a demonstrated interaction between Cav1.2 and G-beta-1, both from unspecified species.BIND15953418 
PCBD1DCOH | PCBD | PCD | PHSpterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha-HPRD,BioGRID11461190 
RYR2ARVC2 | ARVD2 | VTSIPryanodine receptor 2 (cardiac)-HPRD,BioGRID11576544 
SLC44A1CD92 | CDW92 | CHTL1 | CTL1 | RP11-287A8.1solute carrier family 44, member 1-HPRD15728831 
SRIFLJ26259 | SCNsorcin-HPRD,BioGRID9668070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_CARDIAC_MUSCLE_CONTRACTION 8051All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
KEGG_TYPE_II_DIABETES_MELLITUS 4741All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 8565All SZGR genes in this pathway
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 7659All SZGR genes in this pathway
KEGG_DILATED_CARDIOMYOPATHY 9268All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_DN 244147All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
XU_GH1_EXOGENOUS_TARGETS_DN 12069All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_UP 13485All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
DUAN_PRDM5_TARGETS 7952All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP 271165All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/107169517011Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-129-5p670267081Ahsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-14013301336m8hsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-153139313991Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-155144814541Ahsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-193733801A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-200bc/42915941600m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-25/32/92/363/367140614121Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-26157315801A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-320173717431Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-33140314101A,m8hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-342662166281A,m8hsa-miR-342brainUCUCACACAGAAAUCGCACCCGUC
miR-37766206626m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-381168416911A,m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-448139213991A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-49415491555m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-496170017071A,m8hsa-miR-496AUUACAUGGCCAAUCUC
miR-505155615621Ahsa-miR-505GUCAACACUUGCUGGUUUCCUC
miR-9616341640m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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