SZGR2

Summary ?

GeneID	80031
Symbol	SEMA6D
Synonyms	-
Description	semaphorin 6D
Reference	MIM:609295\|HGNC:HGNC:16770\|Ensembl:ENSG00000137872\|HPRD:10221\|Vega:OTTHUMG00000172110
Gene type	protein-coding
Map location	15q21.1
Pascal p-value	1.932E-4
eGene	Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004872	receptor activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007399	nervous system development	IEA	neurite (GO term level: 5)	-
GO:0007275	multicellular organismal development	IEA		-
GO:0016254	preassembly of GPI anchor in ER membrane	EXP		11102867
GO:0030154	cell differentiation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	IEA		-
GO:0016021	integral to membrane	IEA		-
GO:0005886	plasma membrane	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG AXON GUIDANCE	129	103	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS	518	242	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	26	19	All SZGR 2.0 genes in this pathway
REACTOME OTHER SEMAPHORIN INTERACTIONS	15	14	All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS	68	53	All SZGR 2.0 genes in this pathway
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION	188	116	All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	17	12	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN	291	176	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS	355	243	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B	392	251	All SZGR 2.0 genes in this pathway
SHI SPARC TARGETS UP	24	17	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS	652	441	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP	175	116	All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN	264	168	All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS UP	43	28	All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP	430	288	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP	295	149	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K9ME3 UP	141	75	All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN	940	425	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL	162	122	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP	116	87	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway
ZWANG DOWN BY 2ND EGF PULSE	293	119	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway
NABA ECM AFFILIATED	171	89	All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED	753	411	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	1495	1502	1A,m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-124.1	1293	1299	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	1292	1299	1A,m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	1292	1299	1A,m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	942	949	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	942	949	1A,m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-144	2310	2316	m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-15/16/195/424/497	831	838	1A,m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-19	414	420	1A	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	414	420	1A	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-200bc/429	914	920	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-221/222	160	166	m8	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
				hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
				hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
				hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-23	1533	1540	1A,m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
				hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
				hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
				hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-26	323	330	1A,m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	323	330	1A,m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-27	943	950	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	943	950	1A,m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-299-5p	1990	1996	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-30-5p	664	671	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-31	861	868	1A,m8	hsa-miR-31	AGGCAAGAUGCUGGCAUAGCUG
miR-31	861	868	1A,m8	hsa-miR-31	AGGCAAGAUGCUGGCAUAGCUG
miR-320	1952	1958	m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-323	1532	1539	1A,m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-323	1532	1539	1A,m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-363	2236	2242	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-381	2355	2361	m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-409-3p	1494	1500	m8	hsa-miR-409-3p	CGAAUGUUGCUCGGUGAACCCCU
miR-496	2404	2411	1A,m8	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-503	832	838	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-505	2167	2173	1A	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC
miR-7	363	369	m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG
miR-9	116	122	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: SEMA6D