Gene Page: C16orf70
Summary ?
| GeneID | 80262 |
| Symbol | C16orf70 |
| Synonyms | C16orf6|LIN10|lin-10 |
| Description | chromosome 16 open reading frame 70 |
| Reference | HGNC:HGNC:29564|Ensembl:ENSG00000125149|HPRD:17460|Vega:OTTHUMG00000137510 |
| Gene type | protein-coding |
| Map location | 16q22.1 |
| Pascal p-value | 0.131 |
| Fetal beta | -2.04 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4684236 | chr3 | 14700045 | C16orf70 | 80262 | 0.07 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AC087749.2 | 0.68 | 0.69 |
| MICALL2 | 0.64 | 0.63 |
| MYO15B | 0.63 | 0.65 |
| C9orf131 | 0.62 | 0.59 |
| GP1BA | 0.60 | 0.58 |
| AC069281.3 | 0.60 | 0.57 |
| CCDC154 | 0.59 | 0.59 |
| ARHGEF1 | 0.59 | 0.60 |
| SSPO | 0.58 | 0.56 |
| TMC4 | 0.58 | 0.56 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CAPZA2 | -0.45 | -0.51 |
| TMCO1 | -0.43 | -0.50 |
| CHMP5 | -0.41 | -0.48 |
| MRPL15 | -0.41 | -0.46 |
| CRYZL1 | -0.41 | -0.50 |
| SUPT4H1 | -0.41 | -0.44 |
| C18orf32 | -0.41 | -0.58 |
| COMMD10 | -0.40 | -0.49 |
| PNPLA8 | -0.40 | -0.41 |
| UBE2N | -0.40 | -0.41 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |