SZGR2

Summary ?

GeneID	80306
Symbol	MED28
Synonyms	1500003D12Rik\|EG1\|magicin
Description	mediator complex subunit 28
Reference	MIM:610311\|HGNC:HGNC:24628\|HPRD:14381\|
Gene type	protein-coding
Map location	4p16
Pascal p-value	0.005

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CCNC	CycC	cyclin C	Affinity Capture-MS	BioGRID	15175163
CDC2L6	CDK11 \| KIAA1028 \| bA346C16.3	cell division cycle 2-like 6 (CDK8-like)	Affinity Capture-MS	BioGRID	15175163
CDK8	K35 \| MGC126074 \| MGC126075	cyclin-dependent kinase 8	Affinity Capture-MS	BioGRID	15175163
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	15467741
KLHL12	C3IP1 \| DKIR \| FLJ27152	kelch-like 12 (Drosophila)	Two-hybrid	BioGRID	16189514
MAGEA11	MAGE-11 \| MAGE11 \| MAGEA-11 \| MGC10511	melanoma antigen family A, 11	Two-hybrid	BioGRID	16189514
MED1	CRSP1 \| CRSP200 \| DRIP205 \| DRIP230 \| MGC71488 \| PBP \| PPARBP \| PPARGBP \| RB18A \| TRAP220 \| TRIP2	mediator complex subunit 1	Affinity Capture-MS	BioGRID	15175163
MED10	L6 \| MGC5309 \| NUT2 \| TRG20	mediator complex subunit 10	Affinity Capture-MS	BioGRID	15175163
MED11	HSPC296 \| MGC88387	mediator complex subunit 11	Affinity Capture-MS	BioGRID	15175163
MED12	CAGH45 \| HOPA \| KIAA0192 \| OPA1 \| TNRC11 \| TRAP230	mediator complex subunit 12	Affinity Capture-MS	BioGRID	15175163
MED13	ARC250 \| DRIP250 \| HSPC221 \| KIAA0593 \| THRAP1 \| TRAP240	mediator complex subunit 13	Affinity Capture-MS	BioGRID	15175163
MED13L	DKFZp781D0112 \| FLJ21627 \| KIAA1025 \| PROSIT240 \| THRAP2 \| TRAP240L	mediator complex subunit 13-like	Affinity Capture-MS	BioGRID	15175163
MED14	CRSP150 \| CRSP2 \| CSRP \| CXorf4 \| DRIP150 \| EXLM1 \| MGC104513 \| RGR1 \| TRAP170	mediator complex subunit 14	Affinity Capture-MS	BioGRID	15175163
MED15	ARC105 \| CAG7A \| CTG7A \| DKFZp686A2214 \| DKFZp762B1216 \| FLJ42282 \| FLJ42935 \| PCQAP \| TIG-1 \| TIG1 \| TNRC7	mediator complex subunit 15	Affinity Capture-MS	BioGRID	15175163
MED16	DRIP92 \| THRAP5 \| TRAP95	mediator complex subunit 16	Affinity Capture-MS	BioGRID	15175163
MED17	CRSP6 \| CRSP77 \| DRIP80 \| FLJ10812 \| TRAP80	mediator complex subunit 17	Affinity Capture-MS	BioGRID	15175163
MED18	FLJ20045 \| p28b	mediator complex subunit 18	Affinity Capture-MS	BioGRID	15175163
MED19	DT2P1G7 \| LCMR1	mediator complex subunit 19	-	HPRD,BioGRID	15175163
MED20	DKFZp586D2223 \| MGC29869 \| PRO0213 \| TRFP	mediator complex subunit 20	Affinity Capture-MS	BioGRID	15175163
MED21	SRB7 \| SURB7	mediator complex subunit 21	Affinity Capture-MS	BioGRID	15175163
MED22	MED24 \| MGC48682 \| SURF5	mediator complex subunit 22	Affinity Capture-MS	BioGRID	15175163
MED23	CRSP130 \| CRSP133 \| CRSP3 \| DKFZp434H0117 \| DRIP130 \| SUR2	mediator complex subunit 23	Affinity Capture-MS	BioGRID	15175163
MED24	ARC100 \| CRSP100 \| CRSP4 \| DRIP100 \| KIAA0130 \| MGC8748 \| THRAP4 \| TRAP100	mediator complex subunit 24	Affinity Capture-MS	BioGRID	15175163
MED25	ACID1 \| ARC92 \| DKFZp434K0512 \| MGC70671 \| P78 \| PTOV2 \| TCBAP0758	mediator complex subunit 25	Affinity Capture-MS	BioGRID	15175163
MED26	CRSP7 \| CRSP70	mediator complex subunit 26	-	HPRD,BioGRID	15175163
MED27	CRAP34 \| CRSP34 \| CRSP8 \| MGC11274 \| TRAP37	mediator complex subunit 27	Affinity Capture-MS	BioGRID	15175163
MED28	1500003D12Rik \| DKFZp434N185 \| EG1 \| magicin	mediator complex subunit 28	Affinity Capture-MS	BioGRID	15175163
MED29	DKFZp434H247 \| IXL	mediator complex subunit 29	Affinity Capture-MS	BioGRID	15175163
MED30	MGC9890 \| THRAP6 \| TRAP25	mediator complex subunit 30	Affinity Capture-MS	BioGRID	15175163
MED30	MGC9890 \| THRAP6 \| TRAP25	mediator complex subunit 30	-	HPRD	11591653
MED31	3110004H13Rik \| CGI-125 \| FLJ27436 \| FLJ36714 \| Soh1	mediator complex subunit 31	Affinity Capture-MS	BioGRID	15175163
MED4	DRIP36 \| FLJ10956 \| HSPC126 \| RP11-90M2.2 \| TRAP36 \| VDRIP	mediator complex subunit 4	Affinity Capture-MS	BioGRID	15175163
MED6	NY-REN-28	mediator complex subunit 6	Affinity Capture-MS	BioGRID	15175163
MED7	CRSP33 \| CRSP9 \| MGC12284	mediator complex subunit 7	Affinity Capture-MS	BioGRID	15175163
MED8	ARC32 \| MGC17544 \| MGC19641	mediator complex subunit 8	Affinity Capture-MS	BioGRID	15175163
MED9	FLJ10193 \| MED25 \| MGC138234	mediator complex subunit 9	-	HPRD,BioGRID	15175163
NF2	ACN \| BANF \| SCH	neurofibromin 2 (merlin)	Affinity Capture-Western Two-hybrid	BioGRID	15467741
NF2	ACN \| BANF \| SCH	neurofibromin 2 (merlin)	-	HPRD	15175163
POLR2A	MGC75453 \| POLR2 \| POLRA \| RPB1 \| RPBh1 \| RPO2 \| RPOL2 \| RpIILS \| hRPB220 \| hsRPB1	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	Affinity Capture-MS	BioGRID	15175163
POLR2B	POL2RB \| RPB2 \| hRPB140 \| hsRPB2	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	Affinity Capture-MS	BioGRID	15175163
POLR2C	RPB3 \| RPB31 \| hRPB33 \| hsRPB3	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	Affinity Capture-MS	BioGRID	15175163
POLR2D	HSRBP4 \| HSRPB4 \| RBP4	polymerase (RNA) II (DNA directed) polypeptide D	Affinity Capture-MS	BioGRID	15175163
POLR2G	MGC138367 \| MGC138369 \| RPB7 \| hRPB19 \| hsRPB7	polymerase (RNA) II (DNA directed) polypeptide G	Affinity Capture-MS	BioGRID	15175163
POLR2J	MGC71910 \| POLR2J1 \| RPB11 \| RPB11A \| RPB11m \| hRPB14	polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa	Affinity Capture-MS	BioGRID	15175163
POLR2L	RBP10 \| RPABC5 \| RPB10 \| RPB10beta \| RPB7.6 \| hRPB7.6 \| hsRPB10b	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	Affinity Capture-MS	BioGRID	15175163
USHBP1	AIEBP \| FLJ38709 \| FLJ90681 \| MCC2	Usher syndrome 1C binding protein 1	Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP	450	256	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO ANDROGEN UP	29	21	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO FORSKOLIN UP	23	17	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN	229	142	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP	552	347	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN	517	309	All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN	371	218	All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C	463	262	All SZGR 2.0 genes in this pathway
YOSHIOKA LIVER CANCER EARLY RECURRENCE DN	65	31	All SZGR 2.0 genes in this pathway
LINSLEY MIR16 TARGETS	206	127	All SZGR 2.0 genes in this pathway
HOLLEMAN PREDNISOLONE RESISTANCE B ALL UP	22	16	All SZGR 2.0 genes in this pathway
HOLLEMAN DAUNORUBICIN B ALL DN	12	10	All SZGR 2.0 genes in this pathway
HOLLEMAN PREDNISOLONE RESISTANCE ALL UP	19	15	All SZGR 2.0 genes in this pathway
HOLLEMAN DAUNORUBICIN ALL DN	8	6	All SZGR 2.0 genes in this pathway
HOLLEMAN ASPARAGINASE RESISTANCE ALL DN	25	14	All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL DN	214	124	All SZGR 2.0 genes in this pathway