SZGR2

Summary ?

GeneID	8175
Symbol	SF3A2
Synonyms	PRP11\|PRPF11\|SAP62\|SF3a66
Description	splicing factor 3a subunit 2
Reference	MIM:600796\|HGNC:HGNC:10766\|Ensembl:ENSG00000104897\|HPRD:02877\|Vega:OTTHUMG00000180414
Gene type	protein-coding
Map location	19p13.3
Pascal p-value	3.246E-4

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MTA1	0.95	0.95
ZC3H18	0.95	0.95
C19orf29	0.94	0.95
EHMT2	0.94	0.95
AKAP8	0.94	0.95
DHX38	0.94	0.95
ZNF212	0.94	0.94
WHSC2	0.94	0.95
RBM10	0.94	0.95
UNK	0.94	0.95

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.76	-0.87
AF347015.27	-0.73	-0.85
MT-CO2	-0.73	-0.85
C5orf53	-0.73	-0.76
IFI27	-0.71	-0.79
B2M	-0.70	-0.76
AF347015.33	-0.70	-0.81
MT-CYB	-0.70	-0.82
AF347015.21	-0.69	-0.89
AF347015.8	-0.69	-0.83

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CHERP	DAN16 \| SCAF6 \| SRA1	calcium homeostasis endoplasmic reticulum protein	Affinity Capture-MS	BioGRID	12234937
DDX42	FLJ43179 \| RHELP \| RNAHP \| SF3b125	DEAD (Asp-Glu-Ala-Asp) box polypeptide 42	Affinity Capture-Western	BioGRID	12234937
DDX46	FLJ25329 \| KIAA0801 \| MGC9936 \| PRPF5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	Affinity Capture-MS Affinity Capture-Western	BioGRID	12234937
DHX15	DBP1 \| DDX15 \| HRH2 \| PRP43 \| PRPF43 \| PrPp43p	DEAH (Asp-Glu-Ala-His) box polypeptide 15	Affinity Capture-MS	BioGRID	12234937
DNAJC8	HSPC331 \| SPF31	DnaJ (Hsp40) homolog, subfamily C, member 8	Affinity Capture-MS	BioGRID	12234937
HMG20B	BRAF25 \| BRAF35 \| FLJ26127 \| HMGX2 \| PP7706 \| SMARCE1r \| SOXL \| pp8857	high-mobility group 20B	Affinity Capture-MS	BioGRID	12234937
HSPD1	CPN60 \| GROEL \| HSP60 \| HSP65 \| HuCHA60 \| SPG13	heat shock 60kDa protein 1 (chaperonin)	Affinity Capture-MS	BioGRID	12234937
HTATSF1	TAT-SF1 \| dJ196E23.2	HIV-1 Tat specific factor 1	-	HPRD,BioGRID	9710584
PHF5A	INI \| MGC1346 \| SF3b14b \| bK223H9.2	PHD finger protein 5A	Affinity Capture-MS	BioGRID	12234937
PUF60	FIR \| FLJ31379 \| RoBPI \| SIAHBP1	poly-U binding splicing factor 60KDa	Affinity Capture-MS	BioGRID	12234937
RBM17	MGC14439 \| SPF45	RNA binding motif protein 17	Affinity Capture-MS	BioGRID	12234937
RETN	ADSF \| FIZZ3 \| MGC126603 \| MGC126609 \| RETN1 \| RSTN \| XCP1	resistin	-	HPRD	8211113
SF3A1	PRP21 \| PRPF21 \| SAP114 \| SF3A120	splicing factor 3a, subunit 1, 120kDa	SF3a66 interacts with SF3a120.	BIND	11533230
SF3A1	PRP21 \| PRPF21 \| SAP114 \| SF3A120	splicing factor 3a, subunit 1, 120kDa	Affinity Capture-MS	BioGRID	12234937
SF3A3	PRP9 \| PRPF9 \| SAP61 \| SF3a60	splicing factor 3a, subunit 3, 60kDa	Affinity Capture-MS	BioGRID	12234937
SF3A3	PRP9 \| PRPF9 \| SAP61 \| SF3a60	splicing factor 3a, subunit 3, 60kDa	-	HPRD	8022796 \|11533230
SF3B1	PRP10 \| PRPF10 \| SAP155 \| SF3b155	splicing factor 3b, subunit 1, 155kDa	Affinity Capture-MS	BioGRID	12234937
SF3B14	CGI-110 \| HSPC175 \| Ht006 \| P14 \| SAP14 \| SF3B14a	splicing factor 3B, 14 kDa subunit	Affinity Capture-MS	BioGRID	12234937
SF3B2	SAP145 \| SF3B145 \| SF3b1 \| SF3b150	splicing factor 3b, subunit 2, 145kDa	Affinity Capture-MS	BioGRID	12234937
SF3B3	KIAA0017 \| RSE1 \| SAP130 \| SF3b130 \| STAF130	splicing factor 3b, subunit 3, 130kDa	Affinity Capture-MS	BioGRID	12234937
SF3B4	MGC10828 \| SAP49 \| SF3b49	splicing factor 3b, subunit 4, 49kDa	Affinity Capture-MS	BioGRID	12234937
SF3B5	MGC3133 \| SF3b10	splicing factor 3b, subunit 5, 10kDa	Affinity Capture-MS	BioGRID	12234937
SFRS1	ASF \| MGC5228 \| SF2 \| SF2p33 \| SRp30a	splicing factor, arginine/serine-rich 1	Affinity Capture-MS	BioGRID	12234937
SMNDC1	SMNR \| SPF30	survival motor neuron domain containing 1	Affinity Capture-MS	BioGRID	12234937
SNRPA1	-	small nuclear ribonucleoprotein polypeptide A'	Affinity Capture-MS	BioGRID	12234937
SNRPB	COD \| SNRPB1 \| SmB/SmB' \| snRNP-B	small nuclear ribonucleoprotein polypeptides B and B1	Affinity Capture-MS	BioGRID	12234937
SNRPB2	MGC24807 \| MGC45309	small nuclear ribonucleoprotein polypeptide B''	Affinity Capture-MS	BioGRID	12234937
SNRPD1	HsT2456 \| SMD1 \| SNRPD	small nuclear ribonucleoprotein D1 polypeptide 16kDa	Affinity Capture-MS	BioGRID	12234937
SNRPD2	SMD2 \| SNRPD1	small nuclear ribonucleoprotein D2 polypeptide 16.5kDa	Affinity Capture-MS	BioGRID	12234937
SNRPD3	SMD3	small nuclear ribonucleoprotein D3 polypeptide 18kDa	Affinity Capture-MS	BioGRID	12234937
SNRPE	B-raf \| SME	small nuclear ribonucleoprotein polypeptide E	Affinity Capture-MS	BioGRID	12234937
SNRPF	SMF	small nuclear ribonucleoprotein polypeptide F	Affinity Capture-MS	BioGRID	12234937
SNRPG	MGC117317 \| SMG	small nuclear ribonucleoprotein polypeptide G	Affinity Capture-MS	BioGRID	12234937
SR140	KIAA0332 \| MGC133197	U2-associated SR140 protein	Affinity Capture-MS	BioGRID	12234937
TRAP1	HSP75 \| HSP90L	TNF receptor-associated protein 1	Affinity Capture-MS	BioGRID	12234937
U2AF1	DKFZp313J1712 \| FP793 \| RN \| RNU2AF1 \| U2AF35 \| U2AFBP	U2 small nuclear RNA auxiliary factor 1	Affinity Capture-MS	BioGRID	12234937
U2AF2	U2AF65	U2 small nuclear RNA auxiliary factor 2	Affinity Capture-MS	BioGRID	12234937

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG SPLICEOSOME	128	72	All SZGR 2.0 genes in this pathway
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	140	77	All SZGR 2.0 genes in this pathway
REACTOME MRNA PROCESSING	161	86	All SZGR 2.0 genes in this pathway
REACTOME MRNA SPLICING	111	58	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP	276	187	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS UP	135	82	All SZGR 2.0 genes in this pathway
MAYBURD RESPONSE TO L663536 UP	29	18	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC	108	74	All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP	110	71	All SZGR 2.0 genes in this pathway
SIMBULAN UV RESPONSE NORMAL DN	33	27	All SZGR 2.0 genes in this pathway
SIMBULAN UV RESPONSE IMMORTALIZED DN	31	26	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
LIAO METASTASIS	539	324	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS	185	114	All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS UP	52	34	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR	532	309	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP	84	58	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
MELLMAN TUT1 TARGETS UP	19	11	All SZGR 2.0 genes in this pathway