Gene Page: CAPZA1

Summary
GeneID  829
Symbol  CAPZA1
Synonyms  CAPPA1|CAPZ|CAZ1
Description  capping protein (actin filament) muscle Z-line, alpha 1
See related  HGNC:1488|MIM:601580|Ensembl:ENSG00000116489|HPRD:03347|
Locus tag  -
Gene type  protein-coding
Map location  1p13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GARS0.910.88
PPP5C0.880.84
HARS0.870.82
SEC61A20.860.82
PPP2R5D0.860.81
PSMD70.860.83
VDAC30.860.84
C14orf1530.850.84
RAP1GDS10.840.82
PSMD10.840.83
Top 10 negatively co-expressed genes
AF347015.2-0.76-0.69
AF347015.33-0.75-0.67
AF347015.31-0.75-0.67
AF347015.8-0.75-0.66
MT-CO2-0.75-0.65
AF347015.21-0.74-0.64
AF347015.27-0.73-0.67
MT-CYB-0.72-0.64
AF347015.15-0.71-0.64
AF347015.26-0.71-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingTAS7665558 
GO:0005515protein bindingIPI17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006461protein complex assemblyTAS9331217 
GO:0006928cell motionTAS16130169 
GO:0030036actin cytoskeleton organizationIEA-
GO:0051016barbed-end actin filament cappingIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0008290F-actin capping protein complexTAS9331217 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD2APCMS | DKFZp586H0519CD2-associated protein-HPRD,BioGRID12690097 
S100BNEF | S100 | S100betaS100 calcium binding protein BReconstituted ComplexBioGRID12470955 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1-HPRD12690097 
TWF2A6RP | A6r | MSTP011 | PTK9Ltwinfilin, actin-binding protein, homolog 2 (Drosophila)Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 132101All SZGR genes in this pathway
REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING 1311All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
LAIHO_COLORECTAL_CANCER_SERRATED_UP 11271All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
SEIDEN_ONCOGENESIS_BY_MET 8853All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_DN 169112All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
KEEN_RESPONSE_TO_ROSIGLITAZONE_DN 10668All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 225124All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
KYNG_RESPONSE_TO_H2O2_VIA_ERCC6_UP 4030All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_DN 8766All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN 8868All SZGR genes in this pathway
KRIEG_KDM3A_TARGETS_NOT_HYPOXIA 208107All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-128107310791Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-1406336391Ahsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-144137143m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-186165171m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-2058238291Ahsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-2147737791Ahsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-266286341Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-2710731079m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-5p118511921A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3305015081A,m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-369-3p13961402m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-37611951201m8hsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-485-5p1261321Ahsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-49513331339m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-5051411471Ahsa-miR-505GUCAACACUUGCUGGUUUCCUC
miR-712451251m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
miR-9928934m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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