Gene Page: CDC45L

Summary
GeneID  8318
Symbol  CDC45L
Synonyms  CDC45|CDC45L2|PORC-PI-1
Description  CDC45 cell division cycle 45-like (S. cerevisiae)
See related  HGNC:1739|MIM:603465|Ensembl:ENSG00000093009|HPRD:09145|
Locus tag  -
Gene type  protein-coding
Map location  22q11.21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI10518787 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000076DNA replication checkpointTAS9660782 
GO:0006270DNA replication initiationTAS9660782 
GO:0006260DNA replicationEXP12791985 
GO:0006260DNA replicationIEA-
GO:0007049cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIDA18029348 
GO:0005634nucleusTAS9660782 
GO:0005654nucleoplasmEXP15226314 |15707391 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
MCM10CNA43 | DNA43 | MGC126776 | PRO2249minichromosome maintenance complex component 10-HPRD15232106 
MCM3HCC5 | MGC1157 | P1-MCM3 | P1.h | RLFBminichromosome maintenance complex component 3Two-hybridBioGRID12614612 
MCM6MCG40308 | Mis5 | P105MCMminichromosome maintenance complex component 6Two-hybridBioGRID12614612 
MCM7CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146minichromosome maintenance complex component 7-HPRD,BioGRID10518787 |12614612 
ORC1LHSORC1 | ORC1 | PARC1origin recognition complex, subunit 1-like (yeast)Two-hybridBioGRID12614612 
ORC2LORC2origin recognition complex, subunit 2-like (yeast)Two-hybridBioGRID12614612 
ORC3LLAT | LATHEO | ORC3origin recognition complex, subunit 3-like (yeast)-HPRD15232106 
ORC6LORC6origin recognition complex, subunit 6 like (yeast)Two-hybridBioGRID12614612 
POLA1DKFZp686K1672 | POLA | p180polymerase (DNA directed), alpha 1, catalytic subunitReconstituted ComplexBioGRID10518787 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 3116All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_CELL_CYCLE_CHECKPOINTS 12470All SZGR genes in this pathway
REACTOME_M_G1_TRANSITION 8145All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION 11263All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_DNA 9253All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 3517All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 3818All SZGR genes in this pathway
REACTOME_UNWINDING_OF_DNA 116All SZGR genes in this pathway
REACTOME_G1_S_SPECIFIC_TRANSCRIPTION 199All SZGR genes in this pathway
REACTOME_G2_M_CHECKPOINTS 4523All SZGR genes in this pathway
REACTOME_S_PHASE 10966All SZGR genes in this pathway
REACTOME_DNA_STRAND_ELONGATION 3018All SZGR genes in this pathway
SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP 15184All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_UP 14686All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_DN 244153All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP 181101All SZGR genes in this pathway
GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_DN 8749All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_DN 228137All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
MISSIAGLIA_REGULATED_BY_METHYLATION_DN 12267All SZGR genes in this pathway
STREICHER_LSM1_TARGETS_UP 4434All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
AMUNDSON_GENOTOXIC_SIGNATURE 10568All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
KAUFFMANN_MELANOMA_RELAPSE_UP 6125All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
SUNG_METASTASIS_STROMA_DN 5434All SZGR genes in this pathway
MORI_IMMATURE_B_LYMPHOCYTE_DN 9055All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_DN 7543All SZGR genes in this pathway
KAUFFMANN_DNA_REPLICATION_GENES 14787All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_UP 6544All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
BURTON_ADIPOGENESIS_3 10164All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP 180114All SZGR genes in this pathway
MOLENAAR_TARGETS_OF_CCND1_AND_CDK4_DN 5825All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_A_DN 187All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
WHITEFORD_PEDIATRIC_CANCER_MARKERS 11663All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
RUIZ_TNC_TARGETS_DN 14279All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 163102All SZGR genes in this pathway
HOFFMANN_IMMATURE_TO_MATURE_B_LYMPHOCYTE_DN 5036All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_DN 185116All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
ZHANG_TLX_TARGETS_DN 8950All SZGR genes in this pathway
CROONQUIST_IL6_DEPRIVATION_DN 9869All SZGR genes in this pathway
CROONQUIST_NRAS_VS_STROMAL_STIMULATION_DN 9965All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_DN 251151All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
WINNEPENNINCKX_MELANOMA_METASTASIS_UP 16286All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_LITERATURE 4425All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_S 16286All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP 229149All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
YU_BAP1_TARGETS 2921All SZGR genes in this pathway


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