Gene Page: CASP10

Summary ?
GeneID843
SymbolCASP10
SynonymsALPS2|FLICE2|MCH4
Descriptioncaspase 10
ReferenceMIM:601762|HGNC:HGNC:1500|Ensembl:ENSG00000003400|HPRD:03458|Vega:OTTHUMG00000132818
Gene typeprotein-coding
Map location2q33-q34
Pascal p-value0.11
Sherlock p-value0.247
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg041526752202085364CASP108.03E-50.2660.025DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SEPT20.790.77
FBXO80.790.72
ALDH9A10.780.78
ELP40.770.70
P4HA10.760.65
PSAT10.760.70
PTTG1IP0.750.70
CDC14A0.740.65
PLOD20.720.62
ABHD40.720.68
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FAM133A-0.31-0.27
RP9P-0.29-0.25
FRMPD4-0.29-0.21
TMEM63C-0.27-0.22
CACNA1I-0.26-0.20
RTN4RL1-0.26-0.19
STRCP-0.26-0.21
SYT7-0.26-0.18
GABBR2-0.25-0.19
FAM159B-0.25-0.07

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGDIAGDIA1 | MGC117248 | RHOGDI | RHOGDI-1Rho GDP dissociation inhibitor (GDI) alphaCo-purificationBioGRID15659383 
BFARBAR | RNF47bifunctional apoptosis regulator-HPRD10716992 
BIDFP497 | MGC15319 | MGC42355BH3 interacting domain death agonistCo-purificationBioGRID15659383 
CASP1ICE | IL1BC | P45caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)Biochemical ActivityBioGRID8962078 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID8962078 
CASP14MGC119078 | MGC119079caspase 14, apoptosis-related cysteine peptidase-HPRD,BioGRID9792675 
CASP2CASP-2 | ICH-1L | ICH-1L/1S | ICH1 | NEDD2caspase 2, apoptosis-related cysteine peptidase-HPRD,BioGRID8962078 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID8962078 
CASP4ICE(rel)II | ICEREL-II | ICH-2 | Mih1/TX | TXcaspase 4, apoptosis-related cysteine peptidase-HPRD,BioGRID8962078 
CASP6MCH2caspase 6, apoptosis-related cysteine peptidase-HPRD,BioGRID8962078 
CASP7CMH-1 | ICE-LAP3 | MCH3caspase 7, apoptosis-related cysteine peptidase-HPRD,BioGRID8962078 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidaseAffinity Capture-Western
Biochemical Activity
Co-purification		BioGRID8962078 |11832478 
|12887920 |15659383 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidase-HPRD9325248 
CASP9APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6caspase 9, apoptosis-related cysteine peptidase-HPRD,BioGRID8962078 
CCAR1CARP-1 | CARP1 | MGC44628 | RP11-437A18.1cell division cycle and apoptosis regulator 1-HPRD15069192 
CFLARCASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPSCASP8 and FADD-like apoptosis regulator-HPRD9208847 |9228018 
|9289491 
CFLARCASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPSCASP8 and FADD-like apoptosis regulatorAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9228018 |9289491 
|12887920 
DEDDCASP8IP1 | DEDD1 | DEFT | FLDED1 | KE05death effector domain containing-HPRD,BioGRID12527898 
DEDD2FLAME-3death effector domain containing 2-HPRD,BioGRID12527898 
DSPDPI | DPIIdesmoplakin-HPRD15500642 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrinCo-purificationBioGRID15659383 
FADDGIG3 | MGC8528 | MORT1Fas (TNFRSF6)-associated via death domain-HPRD9045686 |11717445|11717445 
FADDGIG3 | MGC8528 | MORT1Fas (TNFRSF6)-associated via death domain-HPRD,BioGRID11717445 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)-HPRD,BioGRID9045686 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)Co-purificationBioGRID15659383 
MAP3K14FTDCR1B | HS | HSNIK | NIKmitogen-activated protein kinase kinase kinase 14Affinity Capture-WesternBioGRID11002417 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8Co-purificationBioGRID15659383 
MSN-moesinCo-purificationBioGRID15659383 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1CASP10 (caspase-10) cleaves RB-1 (hRB) at the DSID consensus site to produce the p68 form.BIND15735701 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member ACo-purificationBioGRID15659383 
RIPK1FLJ39204 | RIP | RIP1receptor (TNFRSF)-interacting serine-threonine kinase 1Affinity Capture-WesternBioGRID11002417 
RYBPAAP1 | DEDAF | YEAF1RING1 and YY1 binding protein-HPRD,BioGRID11395500 
TNFRSF10AAPO2 | CD261 | DR4 | MGC9365 | TRAILR-1 | TRAILR1tumor necrosis factor receptor superfamily, member 10aAffinity Capture-WesternBioGRID9325248 
TNFRSF10BCD262 | DR5 | KILLER | KILLER/DR5 | TRAIL-R2 | TRAILR2 | TRICK2 | TRICK2A | TRICK2B | TRICKB | ZTNFR9tumor necrosis factor receptor superfamily, member 10bAffinity Capture-Western
Co-purification		BioGRID9325248 |15659383 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1A-HPRD11098060 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1AAffinity Capture-Western
Co-purification		BioGRID9045686 |15659383 
TRAF1EBI6 | MGC:10353TNF receptor-associated factor 1Biochemical ActivityBioGRID11098060 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG APOPTOSIS 8862All SZGR 2.0 genes in this pathway
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY 7151All SZGR 2.0 genes in this pathway
BIOCARTA CASPASE PATHWAY 2315All SZGR 2.0 genes in this pathway
BIOCARTA D4GDI PATHWAY 138All SZGR 2.0 genes in this pathway
BIOCARTA FAS PATHWAY 3022All SZGR 2.0 genes in this pathway
BIOCARTA DEATH PATHWAY 3324All SZGR 2.0 genes in this pathway
SA CASPASE CASCADE 1913All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY 6554All SZGR 2.0 genes in this pathway
PID TRAIL PATHWAY 2820All SZGR 2.0 genes in this pathway
PID FAS PATHWAY 3829All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY 13794All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY 5239All SZGR 2.0 genes in this pathway
REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS 138All SZGR 2.0 genes in this pathway
REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 129All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS 7357All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 14894All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206111All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276187All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA DN 10459All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456228All SZGR 2.0 genes in this pathway
NUNODA RESPONSE TO DASATINIB IMATINIB DN 1310All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207128All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
CALVET IRINOTECAN SENSITIVE VS RESISTANT DN 55All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE UP 7851All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA DN 3929All SZGR 2.0 genes in this pathway
CHIARETTI ACUTE LYMPHOBLASTIC LEUKEMIA ZAP70 6733All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR UP 3731All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP 180125All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C3 3624All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
ZHAN EARLY DIFFERENTIATION GENES UP 76All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 1HR UP 1710All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway